Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Table 4 P-tau biomarker means, mean fold-change, statistical tests and effect sizes between amyloid-PET positive and negative groups in BioFINDER-2

	Aβ-	Aβ +	Log 2 Fold-change	Comparison t-value	p-value	Effect Size
Immunoassay p-tau₁₈₁	42.23 (17.29)	118.44 (80.22)	1.49	11.68	< 0.001	1.48
MS p-tau₁₈₁	10.36 (3.68)	14.81 (7.21)	0.52	5.83	< 0.001	0.84
Immunoassay p-tau₂₁₇	53.76 (36.11)	273.05 (224.88)	2.34	13.98	< 0.001	1.55
MS p-tau₂₁₇	0.78 (0.51)	2.98 (2.41)	1.93	11.87	< 0.001	1.42
Immunoassay p-tau₂₃₁	10.99 (5.80)	26.28 (13.03)	1.26	12.33	< 0.001	1.65
MS p-tau₂₃₁	0.20 (0.28)	1.20 (1.99)	2.60	9.73	< 0.001	0.80

P-tau biomarker means are reported in pg./ml for the immunoassays, and in fmol/ml for the MS assays. T-tests were carried out using log-transformed p-tau biomarker data. Effect sizes are reported as Cohen’s d

ISSN: 1750-1326