Table 5 Area under the curve comparisons for plasma and CSF biomarkers for the identification of amyloid-PET positivity in the TRIAD cohort

Amyloid-PET positivity in whole cohortsss

 p-tau₁₈₁

88% (81–95%)

80% (73–87%)

1 – 17%

0.03

 p-tau₂₁₇

94% (90–98%)

92% (87–97%)

-3 – 3%

0.95

 p-tau₂₃₁

92% (87–96%)

92% (88–97%)

-4 – 3%

0.68

Amyloid-PET positivity in CU individuals

 p-tau₁₈₁

83% (72–94%)

79% (69–88%)

-9 – 26%

0.33

 p-tau₂₁₇

90% (80–98%)

90% (79–98%)

-6 – 6%

0.99

 p-tau₂₃₁

88% (78–97%)

91% (81–99%)

-9 – 2%

0.25

Amyloid-PET positivity in CI individuals

 p-tau₁₈₁

87% (77–96%)

74% (65–84%)

-1 – 20%

0.08

 p-tau₂₁₇

91% (81–98%)

86% (77–95%)

-1 – 11%

0.09

 p-tau₂₃₁

87% (78–97%)

86% (76–96%)

-5 – 8%

0.71