Table 6 Area under the curve comparisons for plasma and CSF biomarkers for the identification of amyloid-PET positivity in the BioFINDER-2 cohort

Amyloid-PET positivity

 p-tau₁₈₁

89% (84–94%)

73% (66–80%)

11 – 20%

 < 0.000

 p-tau₂₁₇

93% (89–96%)

89% (84–94%)

1 – 7%

0.023

 p-tau₂₃₁

90% (85–94%)

84% (79–90%)

0 – 11%

0.052

Amyloid-PET positivity in CU individuals

 p-tau₁₈₁

93% (89–97%)

76% (67–85%)

10 – 23%

 < 0.000

 p-tau₂₁₇

96% (94–99%)

92% (87–97%)

1 – 8%

0.020

 p-tau₂₃₁

93% (89–97%)

87% (81–94%)

-1 – 12%

0.092

Amyloid-PET positivity in CI individuals

 p-tau₁₈₁

84% (76–93%)

72% (60–84%)

4 – 20%

0.003

 p-tau₂₁₇

86% (78–94%)

82% (72–92%)

-2 – 10%

0.152

 p-tau₂₃₁

85% (75–95%)

78% (67–89%)

-5 – 18%

0.247