Skip to main content
Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

Fig. 4

The transcription-translation feedback loop (TTFL), the endogenous molecular circadian clock. The molecular circadian clock operates through the TTFL. The diagram illustrates a simplified representation of the TTFL scheme in human cells capable of exhibiting circadian rhythms. These rhythms are appropriately entrained when the suprachiasmatic nucleus (SCN) is intact, emphasizing its crucial role in maintaining the proper functioning of the circadian system. Abbreviations: BMAL1: Basic helix-loop-helix aryl hydrocarbon receptor nuclear translocator-like 1, CLOCK: Clock circadian regulator, CRY: Cryptochrome, PER: Period, REV-ERB: NR1D1 (Nuclear receptor subfamily 1 group D member 1), ROR: Retinoid-related orphan receptor, RRE: REV-ERB/ROR response element

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326