Table 1 Evidence from clinical and neuronal investigations of sleep-wake dyshomeostasis and circadian dysregulations in pathologically confirmed tauopathies
Tauopathies (confirmed pathologically) with sleep-wake dyshomeostasis and circadian dysregulations | Evidence of sleep-wake-circadian disturbances in clinical records | Investigation of the neuronal basis of sleep-wake disturbances a) | Reference a) | |
|---|---|---|---|---|
3R + 4R | Alzheimer’s disease (AD) | Yes | Yes | |
Chronic traumatic encephalopathy (CTE) | Yes | Yes | ||
Postencephalitic parkinsonism | Yes b) | Not tested | [19] | |
Primary age-related tauopathy (PART) | Not tested | Not tested | ||
4R | Progressive supranuclear palsy (PSP) | Yes | Yes | |
Corticobasal degeneration (CBD) | Yes | Yes | ||
Argyrophilic grain disease (AGD) | No | Not tested | ||
Aging-related tau astrogliopathy (ARTAG) | No | Not tested | ||
Globular oligodendroglial inclusions (GGT) | Not tested | Not tested | ||
3R | Pick’s disease (PiD) | Yes | Not tested | |