Fig. 2

Forest Plot of The Estimated Effects of Regional P-tau Pathology on Standardized Cognitive Scales. Legend: Standardized estimates and associated 95% confidence intervals are from the multivariable OLS regression models (Table 4). The whiskers represent the 95% confidence intervals. Regional p-tau severity was rated on a 0–3 scale with 0 being none and 3 being severe. Frontal is a summary composite of the dorsolateral frontal cortex and the inferior frontal cortex. CA1, CA2, and CA4 were summed to create the hippocampus composite. For all clinical scales, higher scores are worse. Abbreviations: OLS Ordinary least squares, CDS Cognitive Difficulties Scale, BRIEF-A Behavior Rating Inventory of Executive Function for Adults, MI Metacognition Index, FAQ Functional Activities Questionnaire