Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy

Table 4 Association between regional p-tau and cognitive and daily function scales: summary of multivariable OLS regression results

	CDS Total Score (n = 284)			CDS Attention Factor Score (n = 284)			CDS Memory Factor Score (n = 284)			CDS Language Factor Score (n = 284)			CDS Motor Factor Score (n = 284)			BRIEF-A MI (n = 285)			FAQ (n = 290)
P-tau ratings	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj
Frontal	0.29	0.18, 0.4	< 0.01	0.3	0.19, 0.41	< 0.01	0.28	0.17, 0.39	< 0.01	0.29	0.17, 0.40	< 0.01	0.23	0.12, 0.35	< 0.01	0.29	0.17, 0.42	< 0.01	0.26	0.16, 0.36	< 0.01
Superior temporal	0.18	0.06, 0.29	< 0.01	0.19	0.08, 0.31	< 0.01	0.18	0.07, 0.29	< 0.01	0.19	0.08, 0.30	< 0.01	0.13	0.01, 0.24	0.09	0.13	0.00, 0.26	0.12	0.21	0.11, 0.30	< 0.01
Inferior parietal	0.25	0.14, 0.35	< 0.01	0.26	0.15, 0.37	< 0.01	0.26	0.15, 0.36	< 0.01	0.24	0.13, 0.35	< 0.01	0.23	0.11, 0.34	< 0.01	0.21	0.08, 0.33	< 0.01	0.22	0.13, 0.31	< 0.01
Amygdala	0.17	0.04, 0.29	0.03	0.2	0.07, 0.33	< 0.01	0.14	0.01, 0.26	0.12	0.19	0.06, 0.32	< 0.01	0.19	0.07, 0.32	< 0.01	0.17	0.03, 0.32	0.07	0.22	0.11, 0.33	< 0.01
Entorhinal	0.01	-0.11, 0.13	0.90	0.03	-0.10, 0.15	0.74	-0.03	-0.15, 0.1	0.90	0.02	-0.1, 0.15	0.80	0.06	-0.06, 0.19	0.58	0.01	-0.13, 0.15	0.92	0.08	-0.03, 0.19	0.34
Hippocampus	-0.01	-0.14, 0.11	0.90	0.00	-0.13, 0.13	0.99	-0.06	-0.18, 0.07	0.84	-0.03	-0.16, 0.1	0.80	0.07	-0.05, 0.20	0.54	0.03	-0.11, 0.17	0.92	0.05	-0.06, 0.16	0.68
Locus coereulus	-0.04	-0.15, 0.06	0.81	-0.06	-0.17, 0.05	0.74	-0.06	-0.17, 0.05	0.72	-0.06	-0.17, 0.05	0.56	-0.02	-0.13, 0.09	0.85	-0.02	-0.14, 0.10	0.92	0.00	-0.1, 0.09	0.99

Abbreviations: OLS Ordinary least squares, CDS Cognitive Difficulties Scale, BRIEF-A Behavior Rating Inventory of Executive Function for Adults, MI Metacognition Index, FAQ Functional Activities Questionnaire
Estimates are standardized betas. Regional p-tau severity was rated on a 0–3 scale with 0 being none and 3 being severe. Frontal is a summary composite of the dorsolateral frontal cortex and the inferior frontal cortex. CA1, CA2, and CA4 were summed to create the hippocampus composite. Each region was examined without other regions in the model. For all clinical scales, higher scores are worse. P-values were false discovery rate adjusted using the Benjamini–Hochberg procedure. Models were adjusted for age at death, racial identity, education level, history of hypertension and obstructive sleep apnea, and history of substance use treatment

ISSN: 1750-1326