Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy

Table 5 Association between regional p-tau and scales of neurobehavioral dysregulation, depression, and apathy: summary of multivariable OLS regression results

	BRIEF-A BRI (n = 285)			BIS-11 (n = 283)			Brown Goodwin (n = 263)			GDS-15 (n = 286)			AES (n = 281)
P-tau ratings	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj	b	95% CI	p_adj
Frontal	0.21	0.08, 0.34	< 0.01	0.11	-0.01, 0.24	0.35	-0.06	-0.19, 0.07	0.53	0.10	-0.03, 0.22	0.4	0.12	-0.01, 0.24	0.35
Superior temporal	0.10	-0.02, 0.23	0.33	0.04	-0.08, 0.16	0.94	-0.06	-0.18, 0.07	0.53	0.05	-0.08, 0.17	0.55	0.07	-0.05, 0.2	0.56
Inferior parietal	0.10	-0.02, 0.23	0.33	0.03	-0.1, 0.15	0.94	-0.07	-0.2, 0.05	0.43	0.07	-0.06, 0.19	0.40	0.13	0.01, 0.25	0.30
Amygdala	0.07	-0.08, 0.21	0.75	0.06	-0.08, 0.2	0.94	0.04	-0.1, 0.19	0.70	0.05	-0.09, 0.19	0.55	0.11	-0.03, 0.26	0.41
Entorhinal	-0.03	-0.16, 0.11	0.91	0.04	-0.09, 0.17	0.94	0.03	-0.11, 0.16	0.72	0.08	-0.05, 0.22	0.40	0.02	-0.11, 0.16	0.76
Hippocampus	0.04	-0.10, 0.18	0.91	< 0.01	-0.14, 0.14	0.97	0.10	-0.04, 0.24	0.34	0.11	-0.03, 0.25	0.40	0.04	-0.1, 0.18	0.76
Locus coereulus	0.01	-0.11, 0.14	0.91	0.01	-0.11, 0.13	0.97	0.03	-0.1, 0.15	0.72	0.01	-0.11, 0.13	0.88	0.03	-0.09, 0.15	0.76

Abbreviations: OLS Ordinary least squares, BRIEF-A Behavior Rating Inventory of Executive Function for Adults, BRI Behavioral Regulation Index, BIS-11 Barratt Impulsiveness Scale, GDS Geriatric Depression Scale, 15-item version, AES Apathy Evaluation Scale
Estimates are standardized betas. Regional p-tau severity was rated on a 0–3 scale with 0 being none and 3 being severe. Frontal is a summary composite of the dorsolateral frontal cortex and the inferior frontal cortex. CA1, CA2, and CA4 were summed to create the hippocampus composite. Each region was examined without other regions in the model. For all clinical scales, higher scores are worse. P-values were false discovery rate adjusted using the Benjamini–Hochberg procedure. Models were adjusted for age at death, racial identity, education level, history of hypertension and obstructive sleep apnea, and history of substance use treatment

ISSN: 1750-1326