Fig. 2
From: Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
NLS-dependent and -independent binding and chaperoning of cargo by nuclear import receptors (NIRs). NIRs recognize their cargo by binding to linear and non-linear motifs. Linear motifs include classical or non-classical NLSs, disordered protein regions, and folded, three-dimensional motifs. This versatility of binding motifs allows NIRs to co- and post-translationally stabilize a plethora of monomeric proteins and dissolve condensates or disaggregate amyloid aggregates. Subsequently, monomeric cargo is guided across the NPC back into the nucleus. PDB-IDs: 7N9H, 2H4M, 2XWU