Fig. 6
From: Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
PD-associated genes and genes near PD-associated variants show cell type-specific expression patterns. A Cell type enriched expression of high-confidence genes associated with monogenic PD. Ln-fold change of SCT-normalized counts is shown (Wilcoxon test, *FDR-corrected p-value < 0.05; see Supplementary Table 5). B-F Pseudo-Manhattan plots of the genes near PD-associated variants generated by MAGMA on the GWAS dataset curated by Nalls and colleagues [32]. The top differentially expressed genes per population/subpopulation which show significant association with PD variants (MAGMA p-value lower than 0.001, ln-fold change > 0.3 for population-level analysis, and ln-fold change > 0.25 for subpopulation-level analysis) are shown; VC, vascular cells; OPC, oligodendrocyte progenitor cells; Micro, microglia; Astro, astrocytes; Oligo, oligodendrocytes. G The number of cell type enriched marker genes that are also near PD-associated variants. The results of two-sided Binomial tests are shown at the top (ns = non-significant). The dashed line shows the expected number of markers given the null hypothesis (see ‘Methods’ and Supplementary Table 9)