Fig. 3

GV-971 alters microbiome metabolism in 5XFAD mice. a Representative heat map of significant amino acids abundance in cecal content of 5XFAD mice treated with 100 mg/kg GV-971 or vehicle from Washington University in St. Louis. b Quantification of amino acid abundance in cecal content of 5XFAD male mice (n = 13). c Quantification of amino acid abundance in cecal content of 5XFAD female mice (n = 9–12). d Representative heat map of significant metabolites in the tryptophan, indole pyruvate, and kynurenine pathway. e Quantification of tryptophan, indole pyruvate, and kynurenine pathway metabolite concentrations in cecal content of 5XFAD male mice (n = 13). f Quantification of tryptophan, indole pyruvate, and kynurenine pathway metabolite concentrations in cecal content of 5XFAD female mice (n = 9–12). g Representative heat map of significant primary and secondary bile acids. h Quantification of primary and secondary bile acids concentrations in cecal content of 5XFAD male mice (n = 13). i Quantification of primary and secondary bile acids concentrations in cecal content of 5XFAD female mice (n = 9–12). Data presented as SEM. Significance determined using unpaired t-test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001