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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

Fig. 6

Single cell RNA-seq shows a decrease in the mitochondrial antioxidant defense in neurons. a. Heat map representing fold change (FC) of the expression of genes encoding proteins involved in mitochondria antioxidant defense between AD (Braak NFT stages V/VI) and control individuals (Braak NFT stages 0/I/II) (from ref. [17]). The color of each box indicates the direction and magnitude of gene expression fold change. Grey color means statistically non-significant (p > 0.05) differences. Note that the expression of mitochondrial antioxidant defense genes is overall downregulated in both excitatory and inhibitory neurons, whereas no change is observed in astrocytes and other cell types. CAT (catalase), GLRX (glutaredoxin), GPX (glutathione peroxidase), GSR (glutathione reductase), GST (glutathione transferase), IDH (isocitrate dehydrogenase), PRDX (peroxiredoxins), ME (malic enzyme), NNT (nicotinamide nucleotide transhydrogenase), SOD2 (manganese superoxide dismutase), TXN2 (thioredoxin), TXNRD (thioredoxin reductase)

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Molecular Neurodegeneration

ISSN: 1750-1326