Fig. 1
From: Brain clearance of protein aggregates: a close-up on astrocytes
Common processes of α-Syn and Tau aggregation in neurons. Schematic representation of α-Syn (A) and Tau (B) structures with depicted some of the most common mutations. Both the proteins include an aggregation prone region (APR), a short sequence of amino acids (6–7 residues) which confers an amyloid-like competence to form β-sheet structures. (C) In physiological conditions amyloidogenic proteins exist mainly as monomers. However, several factors may contribute to the progressive formation of oligomers and filaments, finally leading to the clinical onset of proteinopathies. Depending on the patient characteristic, α-Syn and Tau can give origin to a spectrum of synucleinopathies and tauopathies, respectively