Table 1 Roles of collagen isoforms in CNS health and disease
CNS compartment | Collagen isoform(s) | Function in CNS | Changes with age or disease |
|---|---|---|---|
Development of CNS | Collagen I, IV, IX, XVIII | Guiding neuronal outgrowth, maturation, circuit formation and synaptogenesis [37,38,39] | Expression compartmentalized in the CNS in adulthood |
Brain meninge basal lamina | Collagen I, III, IV | Increased/decreased deposition of collagen IV [42] | |
Vascular basal lamina | Collagen IV, VII, XVIII | Lines blood vessels forming the blood-brain barrier | Increased deposition of collagen XVIII [43, 44], upregulation/breakdown of collagen IV [45,46,47,48,49] |
Perineuronal nets (PNNs) | Collagen XIX (IV in disease states) | Stabilizing neuronal synapses | Upregulation of collagen IV production and loss of collagen XIX [50,51,52] |