Fig. 1

Correlation of suspension bead array-measured CSF proteins to amyloid beta peptides, tau and NfL markers. A Correlation heatmap for amyloid and tau positive (A+T+) individuals with SCD, MCI or AD. The heatmap is annotated with Spearman’s correlations of the proteins to albumin CSF/serum quotient (Q-Alb) B Correlation heatmap for amyloid and tau negative (A-T-) individuals with SCD, annotated with clusters from (A) and Spearman’s correlation with Q-Alb (C, D) Stacked histogram showing the correlation coefficients of amyloid-associated and tau-associated cluster proteins with p-tau (left) and Aβ42 (right) in A+T+ individuals (C) and A-T- (SCD) individuals (D). (E) Volcano plot showing CSF proteins with altered levels in A-T- (SCD) individuals compared to A+T+ individuals. The proteins are colored based on their cluster origin