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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: CSF protein ratios with enhanced potential to reflect Alzheimer’s disease pathology and neurodegeneration

Fig. 3

Correlation between CSF protein levels and cognitive scores. A Stacked histogram showing correlations coefficients between CSF proteomic data and cognitive data in the discovery cohort. The correlations were calculated and shown for ratios of CSF levels of two proteins from distinct clusters, and for CSF levels of individual proteins. B Correlation between CSF SNCB/PTPRN2 ratio and individual cognitive scores in the discovery cohort. One data point was removed for visualisation reasons from the MoCA correlation (MoCA = 13, SNCB/PTPRN2 = 0.36). The trendline was obtained using linear regression. C Correlation between CSF amyloid beta peptides, tau and NfL markers and cognitive scores in the discovery cohort. D Stacked histogram showing correlations between CSF proteomic data and cognitive data in the validation cohort. The correlations were calculated and shown for ratios of CSF levels of two proteins from distinct clusters, and for CSF levels of individual proteins. E Correlation between CSF SNCB/PTPRN2 ratio and MMSE in the validation cohort

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Molecular Neurodegeneration

ISSN: 1750-1326