Skip to main content

Table 1 Sample demographics

From: CSF protein ratios with enhanced potential to reflect Alzheimer’s disease pathology and neurodegeneration

 

Discovery cohort

Validation cohort

A-T- with SCD

A+T+

A-T- with SCD

A+T+

Number of individuals

106

65

26

26

Diagnosis - SCD/MCI/AD

106/0/0

11/19/35

26/0/0

0/0/26

Agea,b

59 (51 –69)

62 (51–74)

59 (51–68)

60 (51–68)

Sex - F/Mc

65/41

41/24

6/20

17/9

Aβ42 (pg/ml)a

1160 (562–2000)

540 (248–990)

1106 (867–1495)

636 (274–804)

Aβ40 (pg/ml) ÷ 10 a

1134 (542–1923)

1225 (558–2185)

-

-

Aβ42/Aβ40 × 10a

1.01 (0.73–1.29)

0.47 (0.26–0.67)

-

-

t-tau (pg/ml)a

214 (75–907)

538 (324–1210)

232 (88–349)

784 (413–2160)

p-tau (pg/ml)a

32 (14–56)

82 (57–190)

38 (22–50)

94 (64–185)

NfL (pg/ml) a,d

670 (310–3960)

1,130 (650–6,550)

-

-

Albumin CSF/serum ratioe

5.70 (2.50–14.40)

5.4 (2.6–11.1)

-

-

MMSE a,f

28.0 (16.0–30.0)

23.0 (14.0–30.0)

29 (25–30)

22 (6–28)

MoCA a,f

26.0 (13–30.0)

20.0 (5.0–28.0)

-

-

KOD a,f

56 (23–98)

44 (1–72)

-

-

RAVLT a,f

50 (27–69)

31 (3–64)

-

-

RCF a,f

18 (2–32)

9 (0–33)

-

-

  1. aThe data is presented in the format: median (range)
  2. bSignificant difference in age distribution was observed between A-T- with SCD and A+T+ groups in the discovery cohort (p = 1.66×10–4, Wilcoxon test). No significant difference was observed in the validation cohort (p = 0.99)
  3. cNo significant difference in sex distribution was observed between A-T-with SCD and A+T+ groups in the discovery cohort (p = 0.87, Fisher’s exact test), but a significant difference was observed in the validation cohort (p = 0.005)
  4. dNfL data availability in discovery cohort [N]: A-T- with SCD: 102, A+T+:64
  5. eAlbumin CSF/serum ratio data availability [N]: A-T- with SCD: 96, A+T+: 62
  6. fCognitive score availability in discovery cohort [N]: A-T- with SCD: 74 MMSE, 92 MoCA, 66 KOD, 70 RAVLT, 69 RCF; A+T+: 44 MMSE, 53 MoCA, 34 KOD, 41 RAVLT, 36 RCF. Cognitive score availability in validation cohort [N]: A-T-: 25 MMSE, A+T+: 26 MMSE