Discovery cohort | Validation cohort | |||
---|---|---|---|---|
A-T- with SCD | A+T+ | A-T- with SCD | A+T+ | |
Number of individuals | 106 | 65 | 26 | 26 |
Diagnosis - SCD/MCI/AD | 106/0/0 | 11/19/35 | 26/0/0 | 0/0/26 |
Agea,b | 59 (51 –69) | 62 (51–74) | 59 (51–68) | 60 (51–68) |
Sex - F/Mc | 65/41 | 41/24 | 6/20 | 17/9 |
Aβ42 (pg/ml)a | 1160 (562–2000) | 540 (248–990) | 1106 (867–1495) | 636 (274–804) |
Aβ40 (pg/ml) ÷ 10 a | 1134 (542–1923) | 1225 (558–2185) | - | - |
Aβ42/Aβ40 × 10a | 1.01 (0.73–1.29) | 0.47 (0.26–0.67) | - | - |
t-tau (pg/ml)a | 214 (75–907) | 538 (324–1210) | 232 (88–349) | 784 (413–2160) |
p-tau (pg/ml)a | 32 (14–56) | 82 (57–190) | 38 (22–50) | 94 (64–185) |
NfL (pg/ml) a,d | 670 (310–3960) | 1,130 (650–6,550) | - | - |
Albumin CSF/serum ratioe | 5.70 (2.50–14.40) | 5.4 (2.6–11.1) | - | - |
MMSE a,f | 28.0 (16.0–30.0) | 23.0 (14.0–30.0) | 29 (25–30) | 22 (6–28) |
MoCA a,f | 26.0 (13–30.0) | 20.0 (5.0–28.0) | - | - |
KOD a,f | 56 (23–98) | 44 (1–72) | - | - |
RAVLT a,f | 50 (27–69) | 31 (3–64) | - | - |
RCF a,f | 18 (2–32) | 9 (0–33) | - | - |