Table 2 ROC AUC for protein pairs in the discovery cohort, and corresponding validation cohort data
Tau-associated protein | Amyloid-associated protein | AUC (CI) discovery | AUC (CI) validation |
|---|---|---|---|
GAP43 | PTPRN2 | 0.98 (0.93–1) | 0.98 (0.94–1) |
GAP43 | NCAN | 0.96 (0.9–1) | 0.94 (0.86–1) |
GAP43 | TMEM132D | 0.96 (0.89–1) | 0.99 (0.98–1) |
GAP43 | CHL1 | 0.95 (0.88–1) | 0.97 (0.92–1) |
GAP43 | CCK | 0.95 (0.87–1) | 0.94 (0.87–0.99) |
GAP43 | NPTX2 | 0.94 (0.84–1) | 0.97 (0.91–1) |
GAP43 | CDH8 | 0.94 (0.84–1) | 0.98 (0.92–1) |
NRGN | PTPRN2 | 0.94 (0.83–1) | 0.94 (0.87–0.99) |
SNCB | PTPRN2 | 0.93 (0.84–1) | 1 (0.98–1) |
GAP43 | PAM | 0.93 (0.84–0.99) | 0.98 (0.95–1) |
SNCB | CCK | 0.93 (0.84–0.99) | 0.95 (0.89–1) |
GAP43 | OMG | 0.93 (0.84–0.99) | 0.91 (0.83–0.98) |
GAP43 | APLP1 | 0.93 (0.84–0.99) | 0.89 (0.79–0.96) |
GAP43 | NPTXR | 0.93 (0.84–1) | 0.87 (0.75–0.97) |
AMPH | PTPRN2 | 0.92 (0.81–0.99) | 0.93 (0.86–0.98) |
GAP43 | NRCAM | 0.92 (0.8–0.99) | 0.9 (0.81–0.97) |
NRGN | NCAN | 0.92 (0.83–0.99) | 0.9 (0.8–0.98) |
GAP43 | NPTX1 | 0.91 (0.8–0.99) | 0.9 (0.8–0.97) |
GAP43 | KIAA1549L | 0.91 (0.8–1) | 0.88 (0.76–0.97) |