Fig. 2
Cross-sectional associations between plasma NTA-tau and Aβ-PET, tau-PET and cortical thickness. Cross-sectional associations between plasma NTA-tau levels and Aβ-PET (A, D), tau-PET (B) and cortical thickness (C, E) by Aβ-status in BioFINDER-2 (A, B and C) and BioFINDER-1 (D and E). Linear regressions with plasma NTA-tau levels as predictor were used to measure the association with Aβ-PET (Centiloids), tau-PET (SUVR), cortical thickness (AD-signature). Standardized β (βstd) and p-values of the associations for each group are shown in the plot coloured accordingly (red: Aβ-positive, blue: Aβ-negative). Age and sex were used as covariates in all cases. Non-AD patients were excluded in the analyses with cortical thickness. Aβ-status was determined using CSF Aβ42/40. *: p < 0.05; **: p < 0.01; ***: p < 0.001. Abbreviations: Aβ, amyloid-β; AD, Alzheimer’s disease; FDR, false discovery rate; nonAD+ ; non-Alzheimer’s type dementia Aβ-positive; SUVR, standardized uptake value ratio