Fig. 4
Cross-sectional associations between plasma NTA-tau and cognition. Cross-sectional associations between plasma NTA-tau levels and MMSE (A and C) and mPACC (B and D) in BioFINDER-2 (A and B) and BioFINDER-1 (C and D). Linear regressions with plasma NTA-tau levels as predictor and cognitive tests as outcome were used to measure the association. Age, sex and years of education were used as covariates in all cases. Only Aβ+ participants within the AD continuum (excluding nonAD+) were included in the analyses. Standardized β (βstd) and p-values of the associations as well as the R2 of the model are shown in the plots. *: p < 0.05; **: p < 0.01; ***: p < 0.001. Abbreviations: Aβ, amyloid-β; AD, Alzheimer’s disease; MMSE, Mini-Mental State Examination; mPACC, mPACC, modified preclinical Alzheimer’s cognitive composite; nonAD+ ; non-Alzheimer’s type dementia Aβ-positive