Fig. 8

Longitudinal plasma NTA-tau association with over time changes in brain atrophy and cognition. Association between longitudinal plasma NTA-tau levels and longitudinal changes in cortical thickness (A) and cognitive performance (B, MMSE; C, mPACC). We used linear mixed models with cognitive measures as outcome and the interaction of plasma NTA-tau longitudinal changes and time as predictor with random intercepts and random time-slopes. Age, sex and education were used as covariates. Plasma NTA-tau longitudinal changes were derived from a linear mixed model with time as the only predictor, with random slopes and intercepts. Dots and thin lines represent individual timepoints and trajectories of cortical thickness or cognitive measures for each participant. Each participant is coloured based on its longitudinal plasma NTA-tau changes. Thick lines and shaded areas represent the mean trajectory over time of each group of plasma NTA-tau slopes and its 95%CI. Only Aβ+ within the AD continuum (excluding nonAD+) were included in these analyses, as were those expected to progress. *: p < 0.05; **: p < 0.01; ***: p < 0.001. Abbreviations: Aβ, amyloid-β; CI, confidence interval; MMSE, Mini-Mental State Examination; mPACC, mPACC, modified preclinical Alzheimer’s cognitive composite; nonAD+ ; non-Alzheimer’s type dementia Aβ-positive