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Table 1 Characteristics of the sample

From: Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease

 

BIOFINDER-2

BIOFINDER-1

All (n = 1,294)

CU- (n = 466)

CU+ (n = 162)

MCI+ (n = 148)

AD+ (n = 189)

nonAD + (n = 79)

nonAD- (n = 250)

p

All (n = 932)

CU- (n = 495)

CU+ (n = 192)

MCI+ (n = 155)

MCI- (n = 90)

p

Age

67.8 (12.5)

60.3 (15.2)

71.6 (9.2)***

72.6 (6.8)***

73.4 (6.9)***

74.6 (6.1)***

70.3 (9.1)***

< 0.001

72.0 (5.4)

71.8 (5.4)

73.2 (5.4)**

72.7 (5.1)*

69.9 (5.6)*

< 0.001

Women, n(%)

623 (48.1%)

251 (53.9%)

82 (50.6%)

66 (44.6%)***

107 (56.6%)

27 (34.2%)***

90 (36.0%)***

< 0.001

532 (57.1%)

313 (63.2%)

119 (62.0%)

73 (47.1%)**

27 (30.0%)***

< 0.001

APOE ε-4 carriers, n(%)a,g

614 (47.4%)

167 (35.8%)

100 (61.7%)***

106 (71.6%)***

134 (70.9%)***

49 (62.0%)***

58 (23.2%)***

< 0.001

273 (29.3%)

55 (11.1%)

91 (47.4%)***

108 (69.7%)***

19 (21.1%)

< 0.001

Education, yearsb,h

12.7 (3.8)

13.0 (3.4)

12.6 (3.7)

12.9 (4.7)

12.2 (4.1)**

13.0 (4.2)

12.0 (3.7)***

< 0.001

11.9 (3.5)

12.2 (3.4)

12.1 (3.8)

11.2 (3.4)**

11.0 (3.4)**

< 0.001

Imaging measures

       

Centiloidsc,i

16.9 (41.0)

-7.50 (7.4)

46.0 (37.8)***

74.3 (39.6)***

95.6 (29.0)***

42.3 (45.6)

-5.00 (10.2)*

< 0.001

37.0 (45.1)

2.06 (7.6)

58.4 (38.5)***

85.9 (34.6)***

5.51 (16.5)

< 0.001

Tau-PET SUVRd

1.34 (0.44)

1.13 (0.09)

1.28 (0.29)***

1.50 (0.44)***

2.11 (0.61)***

1.28 (0.20)***

1.16 (0.09)***

< 0.001

-

-

-

-

-

-

Cortical thicknessJ

2.51 (0.15)

2.60 (0.11)

2.54 (0.12)***

2.47 (0.11)***

2.35 (0.14)***

2.37 (0.16)***

2.52 (0.14)***

< 0.001

2.52 (0.20)

2.58 (0.16)

2.53 (0.20)

2.41 (0.22)***

2.49 (0.22)**

< 0.001

Cognition

       

MMSEe

26.7 (4.00)

29.0 (1.16)

28.7 (1.34)**

26.7 (1.86)***

20.8 (4.31)***

23.5 (5.51)***

26.4 (3.35)***

< 0.001

28.4 (1.7)

29.0 (1.1)

28.7 (1.4)*

26.6 (1.8)***

27.5 (1.9)***

< 0.001

mPACCf

-1.19 (1.88)

0.18 (0.69)

-0.28 (0.76)***

-1.96 (0.90)***

-3.99 (1.75)***

-2.70 (2.04)***

-1.74 (1.57)***

< 0.001

-0.80 (1.16)

-0.15 (0.74)

-0.49 (0.83)***

-2.14 (1.00)***

-1.54 (0.90)***

< 0.001

Plasma levels

       

Plasma NTA

0.258 (0.165)

0.205 (0.112)

0.266 (0.150)***

0.285 (0.145)***

0.444 (0.212)***

0.239 (0.133)*

0.204 (0.128)

< 0.001

0.132 (0.123)

0.114 (0.113)

0.140 (0.0941)***

0.189 (0.154)***

0.118 (0.134)

< 0.001

  1. P-values show differences among groups as calculated with Kruskal–Wallis or Chi-squared tests. Post-hoc analyses against CU- group are shown in the cells. *: p < 0.05; **: p < 0.01; ***: p < 0.001. Mean (SD) is reported unless otherwise indicated
  2. Abbreviations: AD+ Alzheimer’s dementia Aβ-positive, A-T- Aβ and tau negative, A+T- Aβ-positive tau negative, A+T+ Aβ and tau positive, A-T+ Aβ-negative tau positive, CU- cognitively unimpaired Aβ-negative, CU+ cognitively unimpaired Aβ-positive, MCI+ mild cognitive impairment Aβ-positive, MMSE Mini-Mental State Examination, nonAD+ non-Alzheimer’s type dementia Aβ-positive, nonAD- non-Alzheimer’s type dementia Aβ-negative, mPACC modified preclinical Alzheimer’s cognitive composite, SUVR standardized uptake value ratio
  3. a 84 participants missing in BioFINDER-1
  4. b 29 participants missing in BioFINDER-1
  5. c 454 participants missing in BioFINDER-1
  6. d 113 participants missing in BioFINDER-1
  7. e 5 participants missing in BioFINDER-1
  8. f 77 participants missing in BioFINDER-1
  9. g 221 participants missing in BioFINDER-2
  10. h 7 participants missing in BioFINDER-2
  11. i 718 participants missing
  12. j 261 participants missing
  13. k 243 participants missing
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Molecular Neurodegeneration

ISSN: 1750-1326