Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease

Table 2 Associations between plasma NTA-tau and Aβ-PET, tau-PET, cortical thickness, and cognition cross-sectionally in BioFINDER-2 and BioFINDER-1

NTA associations with:		β [95%CI] Aβ-negative	p Aβ-negative	β [95%CI] Aβ-positive	p Aβ-positive
BIOFINDER-2	Aβ-PET	-0.04 [-0.12, 0.04]	0.372	0.28 [0.18, 0.39]	< 0.001
	Tau-PET	0.01 [-0.06, 0.08]	0.772	0.54 [0.46, 0.61]	< 0.001
	Cortical thickness	-0.01 [-0.09, 0.08]	0.845	-0.31 [-0.40, -0.23]	< 0.001
	MMSE	-	-	-0.46 [-0.54, -0.38]	< 0.001
	mPACC	-	-	-0.38 [-0.46, -0.30]	< 0.001
BIOFINDER-1	Aβ-PET	0 [-0.19, 0.19]	0.989	0.43 [0.25, 0.61]	< 0.001
	Cortical thickness	-0.04 [-0.14, 0.05]	0.388	-0.30 [-0.41, -0.20]	< 0.001
	MMSE	-	-	-0.52 [-0.71, -0.33]	< 0.001
	MPACC	-	-	-0.41 [-0.54, -0.28]	< 0.001

Linear regressions with plasma NTA-tau levels as predictor were used to measure the association with Aβ-PET (SUVR), tau-PET (SUVR), cortical thickness (AD-signature) and cognition (MMSE and mPACC) by Aβ-status. Age and sex (and education for cognition) were used as covariates. Non-AD patients were excluded in the analyses with cortical thickness and cognitive measures
Abbreviations: Aβ amyloid-β, AD Alzheimer’s disease, MMSE Mini-Mental State Examination, nonAD+ non-Alzheimer’s type dementia Aβ positive, mPACC modified preclinical Alzheimer’s cognitive composite, SUVR standardized uptake value ratio

ISSN: 1750-1326