NTA associations with: | n | β[95%CI] | p | R2 |
|---|
BioFINDER-2 |
Tau-PET | 294 | 0.06 [0.05, 0.08] | <0.001 | 0.27 |
Cortical thickness | 288 | -0.1 [-0.13, -0.08] | <0.001 | 0.18 |
MMSE | 441 | -1.04 [-1.27, -0.81] | <0.001 | 0.28 |
mPACC | 380 | -0.42 [-0.52, -0.32] | <0.001 | 0.27 |
BioFINDER-1 |
Cortical thickness | 212 | -0.13 [-0.16, -0.1] | < 0.001 | 0.29 |
MMSE | 324 | -1.96 [-2.29, -1.63] | < 0.001 | 0.37 |
mPACC | 211 | -0.41 [-0.52, -0.31] | < 0.001 | 0.29 |
- We used linear mixed models with tau-PET, cortical thickness or cognition (mPACC and MMSE) as outcome and the interaction of baseline plasma biomarkers and time as predictor with random intercepts and random time-slopes. Age and sex (and years of education for cognition) were used as covariates. Only Aβ+ within the AD continuum (excluding nonAD+) were included in these analyses, as were those expected to progress
- Abbreviations: Aβ amyloid-β, AD Alzheimer’s disease, MMSE Mini-Mental State Examination, nonAD+ non-Alzheimer’s type dementia Aβ positive, mPACC modified preclinical Alzheimer’s cognitive composite, SUVR standardized uptake value ratio
