Fig. 2

Comparison of molecular gene signatures between AD mouse model datasets and human AD brain datasets. Heatmap shows the p value significance (-Log₁₀adjusted p values) of the overlaps between AD mouse model molecular signatures and human brain molecular signatures in relate to multiple cognitive/pathological traits (plaque means, CDR, Braak score, CERAD) derived from the PHG brain regions of the Mount Sinai Brain Bank (MSBB) cohort. Axis labels denote the trait contrasts for each gene signature overlap between mouse and human studies. Down- and up-regulated gene signatures are labeled in blue and red colors, respectively