Fig. 6
Global alterations in brain lipidome are displayed by mice lacking β-glucocerebrosidase in oligodendrocytes. a-f LC–MS sphingolipid levels in brain extracts from 6-month-old Gba1f/f and Gba1f/f::cre mice. Mono- (a) and di-hexosylceramides (b), hexosylsphingosine (c) ceramides (d), sphingoid bases (Sph, sphingosine; DhSph, dihydrosphingosine) and sphingosine-1-phosphate (S1P) (e), dihydroceramides (f), sphingomyelins (g) were quantified based on ratio with internal standards as described in Methods (*, p < 0.05, **, p < 0.01, ***, p < 0.001; unpaired two-tailed Student’s t-test; n = 4). Error bars indicate s.e.m