Fig. 8
Behavioral analysis of Gba1f/f::cre shows altered locomotor activity and worse olfactory performance. a, b Analysis of gait in 6-month-old Gba1f/f and Gba1f/f::cre male mice. Stride length (a) and hindlimb base width (b) were measured (*, p < 0.05; unpaired two-tailed Student’s t-test; n = 16 Gba1f/f and n = 20 Gba1f/f::cre mice). Error bars indicate maximum and minimum values. c, d Analysis of gait in 6-month-old Gba1f/f and Gba1f/f::cre female mice. Stride length (c) and hindlimb base width (d) were measured (**, p < 0.01; Unpaired two-tailed Student’s t-test; n = 16 Gba1f/f and n = 20 Gba1f/f::cre mice). Error bars indicate maximum and minimum values. e–g Open field locomotion test in 6-month-old Gba1f/f and Gba1f/f::cre male mice. The total distance traveled (e, f) and time spent in the internal zone (g) were measured (n = 8 Gba1f/f and n = 9 Gba1f/f::cre mice). h-j Open field locomotion test in 6-month-old Gba1f/f and Gba1f/f::cre female mice. The total distance traveled (h, i) and time spent in the internal zone (j) were measured (*, p < 0.05; **, p < 0.01; unpaired two-tailed Student’s t-test; n = 9 Gba1f/f and n = 11 Gba1f/f::cre mice). Error bars indicate maximum and minimum values. k, l Rotarod performance of 6-month-old Gba1f/f and Gba1f/f::cre male (k) and female (l) mice. Results are shown as the average of the best performance from each (unpaired two-tailed Student’s t-test; n = 6 Gba1f/f and n = 10 Gba1f/f::cre male mice and n = 6 Gba1f/f and n = 11 Gba1f/f::cre female mice). Error bars indicate maximum and minimum values. m, n Performance in the buried pellet test for olfactory testing of male and female mice at 6 months of age is shown (unpaired two-tailed Student’s t-test; n = 11 Gba1f/f and n = 8 Gba1f/f::cre mice for females and n = 9 Gba1f/f and n = 10 Gba1f/f::cre mice). Error bars indicate maximum and minimum values