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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12

Fig. 1

APOE genotype does not affect microglia density and morphology. A Representative images of microglia in the entorhinal cortex (EC) and hippocampus (CA1) from APOE3 (E3) and APOE4 (E4) mice. Scale bar = 50 µm. B Quantification of microglia density. Bars represent the mean ± SEM cell density in analyzed fields, and symbols (circles, male; triangle, females) represent data points for each animal. 2–3 brain slices per animal, 4 animals per genotype per sex. C Schematic of microglia morphology analysis. Scale bar 25µm. D Quantification of microglial endpoint/cell (left) and branch length/cell (right) of the EC and CA1 of E3 and E4 mice. Bars represent the mean ± SEM microglial endpoint/cell and branch length/cell in analyzed fields, and symbols (circles, male; triangle, females) represent data points for each animal. 2–3 brain slices per animal, 4 animals per genotype per sex. *p < 0.05; unpaired two-tailed Student’s t test

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Molecular Neurodegeneration

ISSN: 1750-1326