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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

Figure 1

Transgene expression in rat hippocampus, 3 weeks post-infusion. A group of test animals (n = 3 per group) was injected with AAV1 vectors and brains analysed for transgene expression (anti-amyloid beta protein, Chemicon, MAB1560, 6E10, specific for human Aβ). No Aβ expression was observed in naïve rat brain. Infusion of AAV1 vectors expressing BRI-Aβ42 and BRI-Aβ40 fusions or APPsw resulted in extensive expression of amyloid β in the dentate gyrus and CA1 fields of the hippocampus, with distinctive expression patterns for each vector. Left panel: low magnification view of unilateral hippocampus, scale bar 250 μm. Middle panel: higher magnification view of dentate gyrus (DG), scale bar 50 μm. Right panel: higher magnification view of CA1, scale bar 50 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326