Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Roques P, Hardy J, et al: Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature. 1991, 353 (6347): 844-846. 10.1038/353844a0.
Article
CAS
PubMed
Google Scholar
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L: A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet. 1992, 1 (5): 345-347. 10.1038/ng0892-345.
Article
CAS
PubMed
Google Scholar
Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002, 297 (5580): 353-356. 10.1126/science.1072994.
Article
CAS
PubMed
Google Scholar
McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T: Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 2005, 47 (2): 191-199. 10.1016/j.neuron.2005.06.030.
Article
PubMed Central
CAS
PubMed
Google Scholar
Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M: Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004, 7 (9): 954-960. 10.1038/nn1302.
Article
CAS
PubMed
Google Scholar
Gregory GC, Halliday GM: What is the dominant Abeta species in human brain tissue? A review. Neurotox Res. 2005, 7 (1-2): 29-41.
Article
CAS
PubMed
Google Scholar
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G: Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996, 274 (5284): 99-102. 10.1126/science.274.5284.99.
Article
CAS
PubMed
Google Scholar
Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS: Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 1997, 19 (4): 939-945. 10.1016/S0896-6273(00)80974-5.
Article
CAS
PubMed
Google Scholar
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K: Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998, 4 (1): 97-100. 10.1038/nm0198-097.
Article
CAS
PubMed
Google Scholar
Gordon MN, Holcomb LA, Jantzen PT, DiCarlo G, Wilcock D, Boyett KW, Connor K, Melachrino J, O'Callaghan JP, Morgan D: Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Exp Neurol. 2002, 173 (2): 183-195. 10.1006/exnr.2001.7754.
Article
CAS
PubMed
Google Scholar
Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP: Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem. 1996, 67 (5): 1882-1896.
Article
CAS
PubMed
Google Scholar
Barger SW, Mattson MP: Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor. Brain Res Mol Brain Res. 1996, 40 (1): 116-126. 10.1016/0169-328X(96)00036-8.
Article
CAS
PubMed
Google Scholar
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE: A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000, 6 (4): 397-404. 10.1038/74656.
Article
CAS
PubMed
Google Scholar
LaFerla FM: Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci. 2002, 3 (11): 862-872. 10.1038/nrn960.
Article
CAS
PubMed
Google Scholar
Dodart JC, Mathis C, Ungerer A: The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes. Rev Neurosci. 2000, 11 (2-3): 75-93.
CAS
PubMed
Google Scholar
Turner PR, O'Connor K, Tate WP, Abraham WC: Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol. 2003, 70 (1): 1-32. 10.1016/S0301-0082(03)00089-3.
Article
CAS
PubMed
Google Scholar
Bour A, Little S, Dodart JC, Kelche C, Mathis C: A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice. Neurobiol Learn Mem. 2004, 81 (1): 27-38. 10.1016/S1074-7427(03)00071-6.
Article
CAS
PubMed
Google Scholar
Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE: Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A. 2006, 103 (18): 7130-7135. 10.1073/pnas.0509695103.
Article
PubMed Central
CAS
PubMed
Google Scholar
During MJ, Young D, Baer K, Lawlor P, Klugmann M: Development and optimization of adeno-associated virus vector transfer into the central nervous system. Methods Mol Med. 2003, 76: 221-236.
CAS
PubMed
Google Scholar
Tenenbaum L, Chtarto A, Lehtonen E, Velu T, Brotchi J, Levivier M: Recombinant AAV-mediated gene delivery to the central nervous system. J Gene Med. 2004, 6 Suppl 1: S212-22. 10.1002/jgm.506.
Article
CAS
PubMed
Google Scholar
Wang C, Wang CM, Clark KR, Sferra TJ: Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain. Gene Ther. 2003, 10 (17): 1528-1534. 10.1038/sj.gt.3302011.
Article
CAS
PubMed
Google Scholar
Kirik D, Rosenblad C, Burger C, Lundberg C, Johansen TE, Muzyczka N, Mandel RJ, Bjorklund A: Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci. 2002, 22 (7): 2780-2791.
CAS
PubMed
Google Scholar
Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P: alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci U S A. 2002, 99 (16): 10813-10818. 10.1073/pnas.152339799.
Article
PubMed Central
CAS
PubMed
Google Scholar
Senut MC, Suhr ST, Kaspar B, Gage FH: Intraneuronal aggregate formation and cell death after viral expression of expanded polyglutamine tracts in the adult rat brain. J Neurosci. 2000, 20 (1): 219-229.
CAS
PubMed
Google Scholar
de Almeida LP, Ross CA, Zala D, Aebischer P, Deglon N: Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. J Neurosci. 2002, 22 (9): 3473-3483.
PubMed
Google Scholar
Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Bjorklund A: Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proc Natl Acad Sci U S A. 2003, 100 (5): 2884-2889. 10.1073/pnas.0536383100.
Article
PubMed Central
CAS
PubMed
Google Scholar
Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, Ghiso J: A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 1999, 399 (6738): 776-781. 10.1038/21637.
Article
CAS
PubMed
Google Scholar
Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Moller M, Braendgaard H, Plant G, Ghiso J, Frangione B: A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A. 2000, 97 (9): 4920-4925. 10.1073/pnas.080076097.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE: Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochim Biophys Acta. 2001, 1537 (1): 58-62.
Article
CAS
PubMed
Google Scholar
LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G: The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet. 1995, 9 (1): 21-30. 10.1038/ng0195-21.
Article
CAS
PubMed
Google Scholar
McGowan E, Eriksen J, Hutton M: A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 2006, 22 (5): 281-289. 10.1016/j.tig.2006.03.007.
Article
CAS
PubMed
Google Scholar
Fryer JD, Taylor JW, DeMattos RB, Bales KR, Paul SM, Parsadanian M, Holtzman DM: Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci. 2003, 23 (21): 7889-7896.
CAS
PubMed
Google Scholar
Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM: Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet. 1997, 17 (3): 263-264. 10.1038/ng1197-263.
Article
CAS
PubMed
Google Scholar
Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V, Ghetti B, Paul SM: Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 1999, 96 (26): 15233-15238. 10.1073/pnas.96.26.15233.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM: Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci. 2005, 25 (11): 2803-2810. 10.1523/JNEUROSCI.5170-04.2005.
Article
CAS
PubMed
Google Scholar
Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH: Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001, 8 (2): 252-265. 10.1006/nbdi.2000.0380.
Article
CAS
PubMed
Google Scholar
Loeffler DA: Using animal models to determine the significance of complement activation in Alzheimer's disease. J Neuroinflammation. 2004, 1 (1): 18-10.1186/1742-2094-1-18.
Article
PubMed Central
PubMed
Google Scholar
Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M, Zhong Y: Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc Natl Acad Sci U S A. 2004, 101 (17): 6623-6628. 10.1073/pnas.0400895101.
Article
PubMed Central
CAS
PubMed
Google Scholar
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM: Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003, 39 (3): 409-421. 10.1016/S0896-6273(03)00434-3.
Article
CAS
PubMed
Google Scholar
Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM: Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003, 24 (8): 1063-1070. 10.1016/j.neurobiolaging.2003.08.012.
Article
CAS
PubMed
Google Scholar
Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D: Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet. 1999, 29 (3): 177-185. 10.1023/A:1021691918517.
Article
CAS
PubMed
Google Scholar
Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK: Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci. 1999, 2 (3): 271-276. 10.1038/6374.
Article
CAS
PubMed
Google Scholar
Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L: Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A. 1999, 96 (6): 3228-3233. 10.1073/pnas.96.6.3228.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG: Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci. 2001, 21 (2): 372-381.
CAS
PubMed
Google Scholar
Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH: The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002, 22 (5): 1858-1867.
CAS
PubMed
Google Scholar
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH: Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci. 2002, 22 (15): 6331-6335.
CAS
PubMed
Google Scholar
Middei S, Daniele S, Caprioli A, Ghirardi O, Ammassari-Teule M: Progressive cognitive decline in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe. Genes Brain Behav. 2006, 5 (3): 249-256. 10.1111/j.1601-183X.2005.00160.x.
Article
CAS
PubMed
Google Scholar
Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE: Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2006, 103 (13): 5161-5166. 10.1073/pnas.0600948103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH: A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006, 440 (7082): 352-357. 10.1038/nature04533.
Article
CAS
PubMed
Google Scholar
Bannerman DM, Grubb M, Deacon RM, Yee BK, Feldon J, Rawlins JN: Ventral hippocampal lesions affect anxiety but not spatial learning. Behav Brain Res. 2003, 139 (1-2): 197-213. 10.1016/S0166-4328(02)00268-1.
Article
CAS
PubMed
Google Scholar
Trivedi MA, Coover GD: Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze. Neurobiol Learn Mem. 2004, 81 (3): 172-184. 10.1016/j.nlm.2004.02.005.
Article
PubMed
Google Scholar
Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T, Zhang WN, Pothuizen HH, Feldon J: Regional dissociations within the hippocampus--memory and anxiety. Neurosci Biobehav Rev. 2004, 28 (3): 273-283. 10.1016/j.neubiorev.2004.03.004.
Article
CAS
PubMed
Google Scholar
Pentkowski NS, Blanchard DC, Lever C, Litvin Y, Blanchard RJ: Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats. Eur J Neurosci. 2006, 23 (8): 2185-2196. 10.1111/j.1460-9568.2006.04754.x.
Article
PubMed
Google Scholar
van Oijen M, Hofman A, Soares HD, Koudstaal PJ, Breteler MM: Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study. Lancet Neurol. 2006, 5 (8): 655-660. 10.1016/S1474-4422(06)70501-4.
Article
CAS
PubMed
Google Scholar
Chen QS, Kagan BL, Hirakura Y, Xie CW: Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res. 2000, 60 (1): 65-72. 10.1002/(SICI)1097-4547(20000401)60:1<65::AID-JNR7>3.0.CO;2-Q.
Article
CAS
PubMed
Google Scholar
Freir DB, Herron CE: Nicotine enhances the depressive actions of A beta 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo. J Neurophysiol. 2003, 89 (6): 2917-2922. 10.1152/jn.00996.2002.
Article
CAS
PubMed
Google Scholar
Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ: Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur J Neurosci. 2004, 19 (10): 2839-2846. 10.1111/j.1460-9568.2004.03389.x.
Article
PubMed
Google Scholar
Roselli F, Tirard M, Lu J, Hutzler P, Lamberti P, Livrea P, Morabito M, Almeida OF: Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. J Neurosci. 2005, 25 (48): 11061-11070. 10.1523/JNEUROSCI.3034-05.2005.
Article
CAS
PubMed
Google Scholar
Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, Greengard P: Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci. 2005, 8 (8): 1051-1058. 10.1038/nn1503.
Article
CAS
PubMed
Google Scholar
Zou LB, Mouri A, Iwata N, Saido TC, Wang D, Wang MW, Mizoguchi H, Noda Y, Nabeshima T: Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. J Pharmacol Exp Ther. 2006, 317 (1): 334-340. 10.1124/jpet.105.095687.
Article
CAS
PubMed
Google Scholar
Miguel-Hidalgo JJ, Alvarez XA, Cacabelos R, Quack G: Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain Res. 2002, 958 (1): 210-221. 10.1016/S0006-8993(02)03731-9.
Article
CAS
PubMed
Google Scholar
Li Y, Qin HQ, Chen QS, Wang JJ: Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats. Life Sci. 2005, 76 (11): 1189-1197. 10.1016/j.lfs.2004.05.039.
Article
CAS
PubMed
Google Scholar
Yamaguchi Y, Miyashita H, Tsunekawa H, Mouri A, Kim HC, Saito K, Matsuno T, Kawashima S, Nabeshima T: Effects of a novel cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat. J Pharmacol Exp Ther. 2006, 317 (3): 1079-1087. 10.1124/jpet.105.098640.
Article
CAS
PubMed
Google Scholar
Olson VG, Heusner CL, Bland RJ, During MJ, Weinshenker D, Palmiter RD: Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward. Science. 2006, 311 (5763): 1017-1020. 10.1126/science.1119311.
Article
CAS
PubMed
Google Scholar
Rashidian J, Iyirhiaro G, Aleyasin H, Rios M, Vincent I, Callaghan S, Bland RJ, Slack RS, During MJ, Park DS: Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci U S A. 2005, 102 (39): 14080-14085. 10.1073/pnas.0500099102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE: Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest. 2006, 116 (1): 193-201. 10.1172/JCI25410.
Article
PubMed Central
CAS
PubMed
Google Scholar