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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity

Figure 6

Diagram showing the signals transduced by NGF leading to Hes1 expression and neuron survival, and their impairment by Aβ. Various steps have been defined here and are shown in red (labelled as 2). The steps in black ((3), (4), (5) and (6)) come from the literature and the steps labelled in blue (1 and 7) are from our previous studies [19–21, 29].

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Molecular Neurodegeneration

ISSN: 1750-1326