Skip to main content

The dishomeostasis of metal ions plays an important role for the cognitive impartment

Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer’s disease (AD) and might underlie memory impairment. The homeostasis of metal ions plays an important role in health and neurodegenerative disease by influencing cellular biochemical pathways. The disturbance of some metal ions may have cytotoxic effects, which may cause cell death leading to neurodegenerative disorders such as AD. The aim of the present study was to investigate metal concentrations in whole blood from Chinese AD patients with APOE ε4 allele carrier. Concentrations of metals (magnesium, calcium, manganese, iron, cobalt, copper, zinc, selenium, cadmium, mercury and lead) were determined in whole blood by inductively coupled plasma mass spectrometry (ICP-MS) in 40 Chinese people with different Mini-mental state examination (MMSE) score. Normal APP processing could be restored when magnesium was adjusted back to physiological concentration. Our findings suggest that supplementation of magnesium has a therapeutic potential for preventing AD. We observed that Plasma Mg, Zn and Se levels were found to be significantly lower in patients with AD compared with controls. Furthermore, there is a significant negative correlation between manganese and MMSE score. Whereas other metal ions have no association with MMSE score. These result suggests that dishomeostasis of metal ions may involve in the progress of AD pathology, and elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of AD and may have therapeutic potential for treating AD in humans.

References

  1. 1.

    Jia Yu, Miao Sun, Zheng Chen, Jiangyang Lu, Yi Liu, Liang Zhou, Xuemin Xu, Dongsheng Fan, Chui DH: Magnesium modulates amyloid precursor protein trafficking and processing. J Alzheimers Dis. 2010, 20 (4): 1091-1106.

    Google Scholar 

  2. 2.

    Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, Huang X, Xiong W, Ren C, Liu XG, Chui DH, Liu G: Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer’s disease mouse model. J Neurosci. 2013, 33 (19): 8423-8441. 10.1523/JNEUROSCI.4610-12.2013.

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Chui DH, et al: . Magnesium in the Central Nervous System. Chapter 18, Magnesium and Alzheimer’s disease. 2012, The University of Adelaide Press, 239-250. Chapter DOI: http://dxdoi.org/10.1017/UPO9780987073051.019, 9780987073051

    Book  Google Scholar 

Download references

Acknowledgements

This work was supported by 973 Program No.2012CB911004 and the NSFC Grants No.No.81171015.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Dehua Chui.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Chui, D., Yang, H., Wang, H. et al. The dishomeostasis of metal ions plays an important role for the cognitive impartment. Mol Neurodegeneration 8, P13 (2013). https://doi.org/10.1186/1750-1326-8-S1-P13

Download citation

Keywords

  • Selenium
  • Inductively Couple Plasma Mass Spectrometry
  • Couple Plasma Mass
  • Allele Carrier
  • MMSE Score