Volume 8 Supplement 1

Molecular Neurodegeneration: Basic biology and disease pathways

Meeting abstracts

This supplement has not been sponsored.

Molecular Neurodegeneration: Basic biology and disease pathways. Go to conference site.

Cannes, France10-12 September 2013

Concatenated PDF 8S1

Page 1 of 2

Decoding Alzheimer’s in the age of genome-wide analyses

Authors: Rudolph E Tanzi

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O1

Content type: Oral presentation Published on: 13 September 2013
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Functional genetics – an approach to mechanisms in Alzheimer’s disease

Authors: Mikko Hiltunen

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O3

Content type: Oral presentation Published on: 13 September 2013
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Role of APP in neuronal function

Authors: Hui Zheng

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O4

Content type: Oral presentation Published on: 13 September 2013
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The biological function of β-secretase

Authors: Christian Haass

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O5

Content type: Oral presentation Published on: 13 September 2013
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Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase

Authors: Stefan Lichtenthaler

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O6

Content type: Oral presentation Published on: 13 September 2013
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BACE1, the Alzheimer’s beta-secretase enzyme, in health and disease

Authors: Robert Vassar

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O7

Content type: Oral presentation Published on: 13 September 2013
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Regulation of dynamic BACE1 trafficking in neurons

Authors: Virginie Buggia-Prévot, Celia G Fernandez, Sean Riordan, Kulandaivelu S Vetrivel, Vinod Udayar, Aureliane Elie, Margaret Lefkow, Jelita Roseman, Xavier Meckler, Sohinee Bhattacharyya, Manju George, Jack Waters, Vytautas P Bindokas, Angèle T Parent, Lawrence Rajendran, Hamid Band…

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O8

Content type: Oral presentation Published on: 13 September 2013
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Endogenous and exogenous regulation of gamma-secretase

Authors: Yueming Li

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O10

Content type: Oral presentation Published on: 13 September 2013
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Function and dysfunction of presenilin in Alzheimer’s disease

Authors: Jie Shen

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O11

Content type: Oral presentation Published on: 13 September 2013
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Genetic analysis of neurodegeneration.. the end game

Authors: John Hardy

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O12

Content type: Oral presentation Published on: 13 September 2013
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Regulation of mitochondrial function by PINK1, Parkin and DJ-1

Authors: Emilie Giaime and Jie Shen

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O13

Content type: Oral presentation Published on: 13 September 2013
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Expanded G4C2 repeats linked to C9ORF72ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic

Authors: Youn-Bok Lee, Han-Jou Chen, João N Peres, Jorge Gomez, Valentina Sardone, Agnes L Nishimura, Emma Scotter, Caroline Vance, Maja Štalekar, Yoshitsugu Adachi, Claire Troakes, Jack Miller, Bradley Smith, Frank Hirth, Boris Rogelj, Corinne Houart…

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O14

Content type: Oral presentation Published on: 13 September 2013
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In situstudies of protein aggregation kinetics with multiparametric and superresolution imaging

Authors: Gabriele Kaminski Schierle, Claire Michel, Eric Rees, Dorothea Pinotsi and Clemens Kaminski

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O15

Content type: Oral presentation Published on: 13 September 2013
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Designing nanoparticles for delivery of neurotrophic proteins

Authors: Angelina Angelova, Borislav Angelov and Sylviane Lesieur

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O16

Content type: Oral presentation Published on: 13 September 2013
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Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer’s disease and tauopathies

Authors: Heike Hering, Danielle Graham, Solenne Ousson, Maud Neny, Audrey Gray, Brandy Giacomozzi, John Joyce, Vikram Dutt, Michael Busch, Andrew Cameron, Leslie Liu-Bujalski, Henry Yu, Hui Tian, Mark Shearman, Anna Quattropani, Bruno Permanne…

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O17

Content type: Oral presentation Published on: 13 September 2013
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Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies

Authors: Steffen J Sahl, Lucien E Weiss, Lana Lau, Judith Frydman and WE Moerner

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O18

Content type: Oral presentation Published on: 13 September 2013
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Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors

Authors: Guojun Bu, Chia-Chen Liu and Takahisa Kanekiyo

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O20

Content type: Oral presentation Published on: 13 September 2013
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Prion-like aspects of cerebral amyloidosis

Authors: Mathias Jucker, Lan Ye and Sarah Fritschi

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O21

Content type: Oral presentation Published on: 13 September 2013
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Secretases: potential and roadblocks on the way to therapy

Authors: Bart De Strooper

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O22

Content type: Oral presentation Published on: 13 September 2013
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A novel mechanism underlying pathogenesis of Down syndrome

Authors: Xin Wang, Yingjun Zhao, Xiaofei Zhang, Ying Zhou, Barbara Ranscht, Fred H Gage, William C Mobley, Yun-wu Zhang, Stuart A Lipton, Wanjin Hong and Huaxi Xu

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O23

Content type: Oral presentation Published on: 13 September 2013
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The transcription factor XBP-1 in neurodegenerative diseases

Authors: Frédéric Checler, Eric Duplan and Cristine Alves da Costa

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O24

Content type: Oral presentation Published on: 13 September 2013
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Transmission of alpha-synuclein in Parkinson’s disease

Authors: Virginia M-Y Lee

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O25

Content type: Oral presentation Published on: 13 September 2013
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Mechanisms of Aβ induced synaptic toxicity

Authors: Edward H Koo

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O26

Content type: Oral presentation Published on: 13 September 2013
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Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD

Authors: Stephanie Fowler, Angie Chiang, Ricky Savjani, Megan Larson, Dorothy Schuler, John Cirrito, Sylvain Lesne and Joanna Jankowsky

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O30

Content type: Oral presentation Published on: 13 September 2013
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Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation

Authors: Alejandro Sodero, Joris Vriens, Debapriya Ghosh, David Stegner, Anna Brachet, Marta Pallotto, Marco Sassoe-Pognetto, Jos Brouwers, Bernd Helms, Bernard Nieswandt, Thomas Voets and Carlos Dotti

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O32

Content type: Oral presentation Published on: 13 September 2013
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Identifying dominant modifiers of mutant FUS toxicity in vivo

Authors: J Gavin Daigle, Nicholas A Lanson, Ian Casci, John Monaghan, Charles Nichols, Dimitri Kryndushkin, Frank Shewmaker and Udai Pandey

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O33

Content type: Oral presentation Published on: 13 September 2013
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Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease

Authors: Todd E Golde, Kevin Felsenstein, Paramita Chakrabarty, Andy Li, Brenda Moore, Jung Joo In, Pedor Cruz, Ashely Price, David Borchelt, Christopher Janus, Carolina Cebballos-Diaz and Awilda Rosario

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O36

Content type: Oral presentation Published on: 13 September 2013
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Tau-focused therapy and tau transmission: Implications for Alzheimer’s Disease and related tauopathies

Authors: John Q Trojanowski

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):O37

Content type: Oral presentation Published on: 13 September 2013
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Methylene blue decreases brain mitochondrial ABAD and amyloid beta levels protecting mitochondrial functions in LPS-mouse model

Authors: Reham M Abdel-Kader, Aya Zakaria and Nabila Hamdi

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P1

Content type: Poster presentation Published on: 13 September 2013
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The composition of the γ-secretase complex defines its Aβ product profile

Authors: Hermien Acx, Lucía Chávez Gutiérrez, Lutgarde Serneels and Bart De Strooper

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P2

Content type: Poster presentation Published on: 13 September 2013
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dld-1 suppression attenuates the detrimental effects of amyloid beta deposition in a Caenorhabditis elegansmodel of Alzheimer’s disease

Authors: Waqar Ahmad and Paul Ebert

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P3

Content type: Poster presentation Published on: 13 September 2013
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A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury

Authors: Emanuela Angelucci, Sandra Moreno, Marcello D’Amelio, Roberta Nardacci, Francesco Cecconi, Paolo Mariottini and Manuela Cervelli

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P4

Content type: Poster presentation Published on: 13 September 2013
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RAGE targeted strategies for Alzheimer’s amyloid β peptide induced blood brain barrier dysfunctions

Authors: Sholpan Askarova, Andrey Tsoy and James C-M Lee

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P5

Content type: Poster presentation Published on: 13 September 2013
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Development of a paradigm to investigate mechanisms of divided and selective attention impairment in the rodent models of Alzheimer’s disease

Authors: Gytis Baranauskas, Natasa Svirskiene and Gytis Svirskis

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P6

Content type: Poster presentation Published on: 13 September 2013
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Neurochemical changes in animal models of Parkinson’s disease

Authors: Mária Baranyi, Elisaveta Milusheva and Beáta Sperlágh

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P7

Content type: Poster presentation Published on: 13 September 2013
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CYP2E1 and Parkinson’s disease in a MPTP-induced C57BL/6 mouse model

Authors: Rahman Basaran, Elcin Deniz Ozdamar and Benay Can-Eke

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P9

Content type: Poster presentation Published on: 13 September 2013
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The pro-neurotrophin receptor sortilin is a major neuronal APOE receptor for catabolism of amyloid-β peptide in the brain

Authors: Anne-Sophie Carlo, Camilla Gustafsen, Guido Mastrobuoni, Morten Nielsen, Stefan Kempa, Claus Munck Petersen and Thomas Willnow

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P10

Content type: Poster presentation Published on: 13 September 2013
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Posterior cortical atrophy: correlation between clinical, neuropsychological, magnetic resonance and positron emission tomography Imaging

Authors: Tinatin Chabrashvili, Haley Lamonica and Bassel Sawaya

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P11

Content type: Poster presentation Published on: 13 September 2013
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Using Caenorhabditis elegans to fight human neurodegenerative diseases

Authors: Xi Chen, Brian Kraemer, Jeff Barclay, Robert Burgoyne and Alan Morgan

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P12

Content type: Poster presentation Published on: 13 September 2013
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The dishomeostasis of metal ions plays an important role for the cognitive impartment

Authors: Dehua Chui, Huan Yang, Hecheng Wang, Tuo JI, Jia Yu, Shouzi Zhang, Zheng Chen and WeiZhong Xiao

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P13

Content type: Poster presentation Published on: 13 September 2013
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Platelet BACE1 levels as a possible biomarker for Alzheimer’s disease

Authors: Boris Decourt, Aaron Walker, Amanda Gonzales, Michael Malek-Ahmadi, Carolyn Liesback, Kathryn Davis, Christine Belden, Sandra Jacobson and Marwan Sabbagh

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P14

Content type: Poster presentation Published on: 13 September 2013
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Altered expression of antioxidant enzymes and autophagic proteins in transglutaminase 2 knockout mice

Authors: Barbara D’Orio, Luana Barone, Anna Fracassi, Francesca Fanelli, Sara Sepe, Marco Segatto, Mauro Piacentini, Roberta Nardacci and Sandra Moreno

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P15

Content type: Poster presentation Published on: 13 September 2013
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Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis

Authors: Siva Sundara Kumar Durairajan, Yingyu Huang, Leilei Chen, Juxian Song, Liangfeng Liu and Min Li

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P16

Content type: Poster presentation Published on: 13 September 2013
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A cell-based model of pathological tau uptake and propagation

Authors: Ben Falcon, Rachel Angers and Michel Goedert

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P17

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Serum from Parkinson’s disease patients presents excess of protein halogenation and nitrosylation, with anomalous nitrosylation of serum α-synuclein as potentially etiological factor

Authors: Emilio Fernandez, Jose-Manuel Garcia-Moreno, Angel Martin de Pablos and Jose Chacon

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P18

Content type: Poster presentation Published on: 13 September 2013
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The role of SorLA in neurotrophic activity and complex behavior

Authors: Simon Glerup, Mart Saarma and Anders Nykjaer

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P19

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Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1

Authors: Mari Takalo, Jayashree Viswanathan, Teemu Natunen, Kaisa MA Kurkinen, Heikki Tanila, Hilkka Soininen, Rudolph E Tanzi, Mikko Hiltunen and Annakaisa Haapasalo

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P20

Content type: Poster presentation Published on: 13 September 2013
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O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

Authors: Kristin Jacobsen and Kerstin Iverfeldt

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P21

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FcgRIIb mediates amyloid-β neurotoxicity and memory impairment in a model of Alzheimer’s disease

Authors: Yong-Keun Jung

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P22

Content type: Poster presentation Published on: 13 September 2013
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Analysis of TDP-43 and its binding partners in neurodegenerative diseases

Authors: Wejdan Kattuah, Claire Troakes, Tibor Hortobagyi, Boris Rogelj and Christopher Shaw

Citation: Molecular Neurodegeneration 2013 8(Suppl 1):P23

Content type: Poster presentation Published on: 13 September 2013
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Molecular Neurodegeneration: Basic biology and disease pathways

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