Table 1 RyR-mediated calcium deregulation in AD

PS1_M146V and PS1_L250S

SH-SY5Y cells

Dantrolene blocked ↑ carbachol-induced [Ca²⁺] signals (vs. wild type PS1)

[93]

3xTgAD mice PS1_M146V KI Tg mice

Primary cortical neurons

↑ caffeine-induced [Ca²⁺] signals (vs. wt neurons)

[94]

PS1_WT, PS1_L286V, PS1 _M146V, PS2 _N141L

PC12 cells

↑ caffeine-induced [Ca²⁺] signals (vs. vector transfected cells)

[95, 96]

APP_wt and APP_swe

SH-SY5Y cells

↑ caffeine-induced [Ca²⁺] signals (vs. vector transfected cells)

[92]

Tg2576 mice

hippocampal primary neurons

↑ caffeine-induced [Ca²⁺] signals (vs. wt neurons)

[92]

PS _M146V KI Tg and 3xTgAD mice

Acute brain slice preparation (6w, 6 mo and 1.5 Y) (*)

↑ caffeine-induced [Ca²⁺] signals

[72, 100]

Dantrolene reduced the IP₃-evoked Ca²⁺ responses (vs. wt-derived brain slices)

Extracellular Aβ42 application

Primary Cortical neurons

siRyR-3 blocked increased ryanodine- and glutamate-induced [Ca²⁺] signals upon Aβ42 application (vs. Aβ42 non-treated neurons)

[91]

PScDKO Tg and 3xTgAD mice

Primary hippocampal neurons

↑ caffeine-induced [Ca²⁺] signals (vs. wt-Tg neurons)

[78]

↑ ER Ca²⁺ pool (vs. wt-Tg neurons)

PScDKO Tg mice

Primary hippocampal neurons

↔ ER Ca²⁺ pool

[97]

↓ caffeine-induced [Ca²⁺] signals (vs. wt neurons)

PS2_N141L Tg and PS2_N141L/APP_swe mice

Primary neuronal cultures and acute brain slice preparation

↓ ER [Ca²⁺]

[101]

↓ IP₃-generating Ca²⁺ responses

↑ caffeine-induced [Ca²⁺] signals (vs. wt-Tg neurons)

PS1_M146VKI Tg and PS1_M146V/APP_swe Tg mice

Acute brain slice preparation

↑ caffeine-induced [Ca2+] signals

[102]

RyR blockade prevents NMDA Ca²⁺ response (vs. wt-derived brain slices)