Weintraub D, Comella CL, Horn S: Parkinson's disease–part 1: pathophysiology, symptoms, burden, diagnosis, and assessment. Am J Manag Care. 2008, 14: S40-S48.
PubMed
Google Scholar
Weintraub D, Comella CL, Horn S: Parkinson's disease–part 2: treatment of motor symptoms. Am J Manag Care. 2008, 14: S49-S58.
PubMed
Google Scholar
Braak H, Rub U, Gai WP, Del Tredici K: Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm. 2003, 110: 517-536. 10.1007/s00702-002-0808-2.
CAS
PubMed
Google Scholar
Jones DR, Moussaud S, McLean P: Targeting heat shock proteins to modulate alpha-synuclein toxicity. Ther Adv Neurol Disord. 2014, 7: 33-51. 10.1177/1756285613493469.
PubMed Central
PubMed
Google Scholar
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M: Alpha-synuclein in Lewy bodies. Nature. 1997, 388: 839-840. 10.1038/42166.
CAS
PubMed
Google Scholar
Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT: Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol. 1998, 57: 334-337. 10.1097/00005072-199804000-00005.
CAS
PubMed
Google Scholar
Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M: Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett. 1998, 251: 205-208. 10.1016/S0304-3940(98)00504-7.
CAS
PubMed
Google Scholar
Brion JP, Couck AM, Passareiro E, Flament-Durand J: Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study. J Submicrosc Cytol. 1985, 17: 89-96.
CAS
PubMed
Google Scholar
Irwin DJ, Lee VM, Trojanowski JQ: Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies. Nat Rev Neurosci. 2013, 14: 626-636. 10.1038/nrn3549.
PubMed Central
CAS
PubMed
Google Scholar
Galpern WR, Lang AE: Interface between tauopathies and synucleinopathies: a tale of two proteins. Ann Neurol. 2006, 59: 449-458. 10.1002/ana.20819.
CAS
PubMed
Google Scholar
Dickson DW, Fujishiro H, DelleDonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE: Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol. 2008, 115: 437-444. 10.1007/s00401-008-0345-7.
PubMed
Google Scholar
Evidente VG, Adler CH, Sabbagh MN, Connor DJ, Hentz JG, Caviness JN, Sue LI, Beach TG: Neuropathological findings of PSP in the elderly without clinical PSP: possible incidental PSP?. Parkinsonism Relat Disord. 2011, 17: 365-371. 10.1016/j.parkreldis.2011.02.017.
PubMed Central
PubMed
Google Scholar
Mikolaenko I, Pletnikova O, Kawas CH, O'Brien R, Resnick SM, Crain B, Troncoso JC: Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuropathol Exp Neurol. 2005, 64: 156-162.
CAS
PubMed
Google Scholar
Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol. 2003, 62: 644-654.
CAS
PubMed
Google Scholar
Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ: Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. Am J Pathol. 2002, 160: 1725-1731. 10.1016/S0002-9440(10)61119-4.
PubMed Central
CAS
PubMed
Google Scholar
Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM, Iwatsubo T, Trojanowski JQ: Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol. 1998, 153: 1365-1370. 10.1016/S0002-9440(10)65722-7.
PubMed Central
CAS
PubMed
Google Scholar
Lippa CF, Schmidt ML, Lee VM, Trojanowski JQ: Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol. 1999, 45: 353-357. 10.1002/1531-8249(199903)45:3<353::AID-ANA11>3.0.CO;2-4.
CAS
PubMed
Google Scholar
Aarsland D, Zaccai J, Brayne C: A systematic review of prevalence studies of dementia in Parkinson's disease. Mov Disord. 2005, 20: 1255-1263. 10.1002/mds.20527.
PubMed
Google Scholar
Braak H, Rub U, Jansen Steur EN, Del Tredici K, de Vos RA: Cognitive status correlates with neuropathologic stage in Parkinson disease. Neurology. 2005, 64: 1404-1410. 10.1212/01.WNL.0000158422.41380.82.
CAS
PubMed
Google Scholar
Hurtig HI, Trojanowski JQ, Galvin J, Ewbank D, Schmidt ML, Lee VM, Clark CM, Glosser G, Stern MB, Gollomp SM, Arnold SE: Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Neurology. 2000, 54: 1916-1921. 10.1212/WNL.54.10.1916.
CAS
PubMed
Google Scholar
Leverenz JB, Quinn JF, Zabetian C, Zhang J, Montine KS, Montine TJ: Cognitive impairment and dementia in patients with Parkinson disease. Curr Top Med Chem. 2009, 9: 903-912.
PubMed Central
CAS
PubMed
Google Scholar
Hamilton RL: Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol. 2000, 10: 378-384.
CAS
PubMed
Google Scholar
Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E, Raskind MA, Schellenberg GD, Bird TD, Tsuang D: Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype. Arch Neurol. 2006, 63: 370-376. 10.1001/archneur.63.3.370.
PubMed Central
PubMed
Google Scholar
Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez O, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Trojanowski JQ, Montine TJ: Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol. 2008, 18: 220-224. 10.1111/j.1750-3639.2007.00117.x.
PubMed Central
PubMed
Google Scholar
Kraybill ML, Larson EB, Tsuang DW, Teri L, McCormick WC, Bowen JD, Kukull WA, Leverenz JB, Cherrier MM: Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology. 2005, 64: 2069-2073. 10.1212/01.WNL.0000165987.89198.65.
PubMed Central
CAS
PubMed
Google Scholar
Bancher C, Braak H, Fischer P, Jellinger KA: Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci Lett. 1993, 162: 179-182. 10.1016/0304-3940(93)90590-H.
CAS
PubMed
Google Scholar
Joachim CL, Morris JH, Kosik KS, Selkoe DJ: Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders. Ann Neurol. 1987, 22: 514-520. 10.1002/ana.410220411.
CAS
PubMed
Google Scholar
Lewy FH: Paralysis agitans. Pathologische Anatomie Handbuch der Neurologie (Ed M Lewandowsky) Julius Springer. 1912, 3: 920-933.
Google Scholar
Schneider JA, Li JL, Li Y, Wilson RS, Kordower JH, Bennett DA: Substantia nigra tangles are related to gait impairment in older persons. Ann Neurol. 2006, 59: 166-173. 10.1002/ana.20723.
PubMed
Google Scholar
Muntane G, Dalfo E, Martinez A, Ferrer I: Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. 2008, 152: 913-923. 10.1016/j.neuroscience.2008.01.030.
CAS
PubMed
Google Scholar
Duda JE, Giasson BI, Mabon ME, Miller DC, Golbe LI, Lee VM, Trojanowski JQ: Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathol. 2002, 104: 7-11. 10.1007/s00401-002-0563-3.
CAS
PubMed
Google Scholar
Fujioka S, Ogaki K, Tacik PM, Uitti RJ, Ross OA, Wszolek ZK: Update on novel familial forms of Parkinson's disease and multiple system atrophy. Parkinsonism Relat Disord. 2014, 20 (Suppl 1): S29-S34.
PubMed Central
PubMed
Google Scholar
Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, Lee VM: Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Exp Neurol. 2004, 187: 279-288. 10.1016/j.expneurol.2004.01.007.
CAS
PubMed
Google Scholar
Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA, Goedert M, Ghetti B: Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene. Acta Neuropathol. 2005, 110: 298-305. 10.1007/s00401-005-1042-4.
PubMed
Google Scholar
Poulopoulos M, Levy OA, Alcalay RN: The neuropathology of genetic Parkinson's disease. Mov Disord. 2012, 27: 831-842. 10.1002/mds.24962.
PubMed Central
CAS
PubMed
Google Scholar
Jellinger KA: Interaction between alpha-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Exp Neurol. 2011, 227: 13-18. 10.1016/j.expneurol.2010.10.006.
CAS
PubMed
Google Scholar
Wills J, Jones J, Haggerty T, Duka V, Joyce JN, Sidhu A: Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol. 2010, 225: 210-218. 10.1016/j.expneurol.2010.06.017.
PubMed Central
CAS
PubMed
Google Scholar
Arima K, Mizutani T, Alim MA, Tonozuka-Uehara H, Izumiyama Y, Hirai S, Ueda K: NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. Acta Neuropathol. 2000, 100: 115-121. 10.1007/s004010050002.
CAS
PubMed
Google Scholar
Ishizawa T, Mattila P, Davies P, Wang D, Dickson DW: Colocalization of tau and alpha-synuclein epitopes in Lewy bodies. J Neuropathol Exp Neurol. 2003, 62: 389-397.
CAS
PubMed
Google Scholar
Leverenz JB, Umar I, Wang Q, Montine TJ, McMillan PJ, Tsuang DW, Jin J, Pan C, Shin J, Zhu D, Zhang J: Proteomic identification of novel proteins in cortical lewy bodies. Brain Pathol. 2007, 17: 139-145. 10.1111/j.1750-3639.2007.00048.x.
CAS
PubMed
Google Scholar
Appel-Cresswell S, Vilarino-Guell C, Encarnacion M, Sherman H, Yu I, Shah B, Weir D, Thompson C, Szu-Tu C, Trinh J, Aasly JO, Rajput A, Rajput AH, Jon Stoessl A, Farrer MJ: Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Mov Disord. 2013, 28: 811-813. 10.1002/mds.25421.
CAS
PubMed
Google Scholar
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, Waucquier N, Defebvre L, Amouyel P, Farrer M, Destee A: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet. 2004, 364: 1167-1169. 10.1016/S0140-6736(04)17103-1.
CAS
PubMed
Google Scholar
Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL: alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?. Acta Neuropathol. 2013, 125: 753-769. 10.1007/s00401-013-1096-7.
PubMed Central
CAS
PubMed
Google Scholar
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet. 1998, 18: 106-108. 10.1038/ng0298-106.
CAS
PubMed
Google Scholar
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997, 276: 2045-2047. 10.1126/science.276.5321.2045.
CAS
PubMed
Google Scholar
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K: alpha-Synuclein locus triplication causes Parkinson's disease. Science. 2003, 302: 841-10.1126/science.1090278.
CAS
PubMed
Google Scholar
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, Llorens V, Gomez Tortosa E, del Ser T, Munoz DG, de Yebenes JG: The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol. 2004, 55: 164-173. 10.1002/ana.10795.
CAS
PubMed
Google Scholar
Clark LN, Poorkaj P, Wszolek Z, Geschwind DH, Nasreddine ZS, Miller B, Li D, Payami H, Awert F, Markopoulou K, Andreadis A, D'Souza I, Lee VM, Reed L, Trojanowski JQ, Zhukareva V, Bird T, Schellenberg G, Wilhelmsen KC: Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Natl Acad Sci U S A. 1998, 95: 13103-13107. 10.1073/pnas.95.22.13103.
PubMed Central
CAS
PubMed
Google Scholar
Dumanchin C, Camuzat A, Campion D, Verpillat P, Hannequin D, Dubois B, Saugier-Veber P, Martin C, Penet C, Charbonnier F, Agid Y, Frebourg T, Brice A: Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism. Hum Mol Genet. 1998, 7: 1825-1829. 10.1093/hmg/7.11.1825.
CAS
PubMed
Google Scholar
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, et al: Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998, 393: 702-705. 10.1038/31508.
CAS
PubMed
Google Scholar
Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD: Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol. 1998, 43: 815-825. 10.1002/ana.410430617.
CAS
PubMed
Google Scholar
Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B: Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci U S A. 1998, 95: 7737-7741. 10.1073/pnas.95.13.7737.
PubMed Central
CAS
PubMed
Google Scholar
D'Souza I, Schellenberg GD: Regulation of tau isoform expression and dementia. Biochim Biophys Acta. 2005, 1739: 104-115. 10.1016/j.bbadis.2004.08.009.
PubMed
Google Scholar
Gendron TF, Petrucelli L: The role of tau in neurodegeneration. Mol Neurodegener. 2009, 4: 13-10.1186/1750-1326-4-13.
PubMed Central
PubMed
Google Scholar
Liu F, Gong CX: Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener. 2008, 3: 8-10.1186/1750-1326-3-8.
PubMed Central
PubMed
Google Scholar
Spillantini MG, Goedert M: Tau pathology and neurodegeneration. Lancet Neurol. 2013, 12: 609-622. 10.1016/S1474-4422(13)70090-5.
CAS
PubMed
Google Scholar
Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N: Two brothers with frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology. 2000, 54: 1787-1795. 10.1212/WNL.54.9.1787.
CAS
PubMed
Google Scholar
Di Maria E, Tabaton M, Vigo T, Abbruzzese G, Bellone E, Donati C, Frasson E, Marchese R, Montagna P, Munoz DG, Pramstaller PP, Zanusso G, Ajmar F, Mandich P: Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy. Ann Neurol. 2000, 47: 374-377. 10.1002/1531-8249(200003)47:3<374::AID-ANA15>3.0.CO;2-8.
CAS
PubMed
Google Scholar
Kouri N, Carlomagno Y, Baker M, Liesinger AM, Caselli RJ, Wszolek ZK, Petrucelli L, Boeve BF, Parisi JE, Josephs KA, Uitti RJ, Ross OA, Graff-Radford NR, Deture MA, Dickson DW, Rademakers R: Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. Acta Neuropathol. 2014, 127: 271-282. 10.1007/s00401-013-1193-7.
PubMed Central
CAS
PubMed
Google Scholar
Baker M, Litvan I, Houlden H, Adamson J, Dickson D, Perez-Tur J, Hardy J, Lynch T, Bigio E, Hutton M: Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Hum Mol Genet. 1999, 8: 711-715. 10.1093/hmg/8.4.711.
CAS
PubMed
Google Scholar
Iijima M, Tabira T, Poorkaj P, Schellenberg GD, Trojanowski JQ, Lee VM, Schmidt ML, Takahashi K, Nabika T, Matsumoto T, Yamashita Y, Yoshioka S, Ishino H: A distinct familial presenile dementia with a novel missense mutation in the tau gene. Neuroreport. 1999, 10: 497-501. 10.1097/00001756-199902250-00010.
CAS
PubMed
Google Scholar
Ittner LM, Fath T, Ke YD, Bi M, van Eersel J, Li KM, Gunning P, Gotz J: Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci U S A. 2008, 105: 15997-16002. 10.1073/pnas.0808084105.
PubMed Central
CAS
PubMed
Google Scholar
Rossi G, Gasparoli E, Pasquali C, Di Fede G, Testa D, Albanese A, Bracco F, Tagliavini F: Progressive supranuclear palsy and Parkinson's disease in a family with a new mutation in the tau gene. Ann Neurol. 2004, 55: 448-
CAS
PubMed
Google Scholar
van Herpen E, Rosso SM, Serverijnen LA, Yoshida H, Breedveld G, van de Graaf R, Kamphorst W, Ravid R, Willemsen R, Dooijes D, Majoor-Krakauer D, Kros JM, Crowther RA, Goedert M, Heutink P, van Swieten JC: Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R. Ann Neurol. 2003, 54: 573-581. 10.1002/ana.10721.
CAS
PubMed
Google Scholar
Jellinger KA: Absence of alpha-synuclein pathology in postencephalitic parkinsonism. Acta Neuropathol. 2009, 118: 371-379. 10.1007/s00401-009-0537-9.
CAS
PubMed
Google Scholar
Lee VM, Giasson BI, Trojanowski JQ: More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends Neurosci. 2004, 27: 129-134. 10.1016/j.tins.2004.01.007.
CAS
PubMed
Google Scholar
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, et al: Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014, 46: 989-993. 10.1038/ng.3043.
PubMed Central
CAS
PubMed
Google Scholar
Labbe C, Ross OA: Association studies of sporadic Parkinson's disease in the genomic era. Curr Genomics. 2014, 15: 2-10. 10.2174/1389202914666131210212745.
PubMed Central
CAS
PubMed
Google Scholar
Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Kruger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, et al: Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009, 41: 1308-1312. 10.1038/ng.487.
PubMed Central
CAS
PubMed
Google Scholar
Spencer CC, Plagnol V, Strange A, Gardner M, Paisan-Ruiz C, Band G, Barker RA, Bellenguez C, Bhatia K, Blackburn H, Blackwell JM, Bramon E, Brown MA, Burn D, Casas JP, Chinnery PF, Clarke CE, Corvin A, Craddock N, Deloukas P, Edkins S, Evans J, Freeman C, Gray E, Hardy J, Hudson G, Hunt S, Jankowski J, Langford C, Lees AJ, et al: Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet. 2011, 20: 345-353.
PubMed Central
CAS
PubMed
Google Scholar
Wade-Martins R: Genetics: the MAPT locus-a genetic paradigm in disease susceptibility. Nat Rev Neurol. 2012, 8: 477-478. 10.1038/nrneurol.2012.169.
CAS
PubMed
Google Scholar
Caffrey TM, Wade-Martins R: The role of MAPT sequence variation in mechanisms of disease susceptibility. Biochem Soc Trans. 2012, 40: 687-692. 10.1042/BST20120063.
CAS
PubMed
Google Scholar
Houlden H, Baker M, Morris HR, MacDonald N, Pickering-Brown S, Adamson J, Lees AJ, Rossor MN, Quinn NP, Kertesz A, Khan MN, Hardy J, Lantos PL, St George-Hyslop P, Munoz DG, Mann D, Lang AE, Bergeron C, Bigio EH, Litvan I, Bhatia KP, Dickson D, Wood NW, Hutton M: Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype. Neurology. 2001, 56: 1702-1706. 10.1212/WNL.56.12.1702.
CAS
PubMed
Google Scholar
Pittman AM, Myers AJ, Abou-Sleiman P, Fung HC, Kaleem M, Marlowe L, Duckworth J, Leung D, Williams D, Kilford L, Thomas N, Morris CM, Dickson D, Wood NW, Hardy J, Lees AJ, de Silva R: Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet. 2005, 42: 837-846. 10.1136/jmg.2005.031377.
PubMed Central
CAS
PubMed
Google Scholar
Zabetian CP, Hutter CM, Factor SA, Nutt JG, Higgins DS, Griffith A, Roberts JW, Leis BC, Kay DM, Yearout D, Montimurro JS, Edwards KL, Samii A, Payami H: Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease. Ann Neurol. 2007, 62: 137-144. 10.1002/ana.21157.
PubMed Central
CAS
PubMed
Google Scholar
Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJ, Brown J, Ban M, Spillantini MG, Compston A, Burn DJ, Chinnery PF, Barker RA, Sawcer SJ: Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease. Ann Neurol. 2007, 62: 145-153. 10.1002/ana.21192.
CAS
PubMed
Google Scholar
Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA: The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. Brain. 2009, 132: 2958-2969. 10.1093/brain/awp245.
PubMed
Google Scholar
Vilarino-Guell C, Soto-Ortolaza AI, Rajput A, Mash DC, Papapetropoulos S, Pahwa R, Lyons KE, Uitti RJ, Wszolek ZK, Dickson DW, Farrer MJ, Ross OA: MAPT H1 haplotype is a risk factor for essential tremor and multiple system atrophy. Neurology. 2011, 76: 670-672. 10.1212/WNL.0b013e31820c30c1.
PubMed Central
CAS
PubMed
Google Scholar
Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, Marder K, Van Der Flier WM, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, et al: Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Hum Mol Genet. 2014, ᅟ: ᅟ-in press
Google Scholar
Colom-Cadena M, Gelpi E, Marti MJ, Charif S, Dols-Icardo O, Blesa R, Clarimon J, Lleo A: MAPT H1 haplotype is associated with enhanced alpha-synuclein deposition in dementia with Lewy bodies. Neurobiol Aging. 2013, 34: 936-942. 10.1016/j.neurobiolaging.2012.06.015.
CAS
PubMed
Google Scholar
Peuralinna T, Oinas M, Polvikoski T, Paetau A, Sulkava R, Niinisto L, Kalimo H, Hernandez D, Hardy J, Singleton A, Tienari PJ, Myllykangas L: Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein. Ann Neurol. 2008, 64: 348-352. 10.1002/ana.21446.
PubMed
Google Scholar
Kwok JB, Hallupp M, Loy CT, Chan DK, Woo J, Mellick GD, Buchanan DD, Silburn PA, Halliday GM, Schofield PR: GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann Neurol. 2005, 58: 829-839. 10.1002/ana.20691.
CAS
PubMed
Google Scholar
Wider C, Vilarino-Guell C, Heckman MG, Jasinska-Myga B, Ortolaza-Soto AI, Diehl NN, Crook JE, Cobb SA, Bacon JA, Aasly JO, Gibson JM, Lynch T, Uitti RJ, Wszolek ZK, Farrer MJ, Ross OA: SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study. Eur J Neurol. 2011, 18: 876-881. 10.1111/j.1468-1331.2010.03297.x.
CAS
PubMed
Google Scholar
Biernacka JM, Armasu SM, Cunningham JM, Ahlskog JE, Chung SJ, Maraganore DM: Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?. Parkinsonism Relat Disord. 2011, 17: 730-736. 10.1016/j.parkreldis.2011.07.001.
PubMed
Google Scholar
Mamah CE, Lesnick TG, Lincoln SJ, Strain KJ, de Andrade M, Bower JH, Ahlskog JE, Rocca WA, Farrer MJ, Maraganore DM: Interaction of alpha-synuclein and tau genotypes in Parkinson's disease. Ann Neurol. 2005, 57: 439-443. 10.1002/ana.20387.
CAS
PubMed
Google Scholar
Elbaz A, Ross OA, Ioannidis JP, Soto-Ortolaza AI, Moisan F, Aasly J, Annesi G, Bozi M, Brighina L, Chartier-Harlin MC, Destee A, Ferrarese C, Ferraris A, Gibson JM, Gispert S, Hadjigeorgiou GM, Jasinska-Myga B, Klein C, Kruger R, Lambert JC, Lohmann K, van de Loo S, Loriot MA, Lynch T, Mellick GD, Mutez E, Nilsson C, Opala G, Puschmann A, Quattrone A, et al: Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. Ann Neurol. 2011, 69: 778-792. 10.1002/ana.22321.
PubMed Central
CAS
PubMed
Google Scholar
Bove J, Perier C: Neurotoxin-based models of Parkinson's disease. Neuroscience. 2012, 211: 51-76.
CAS
PubMed
Google Scholar
Duka T, Rusnak M, Drolet RE, Duka V, Wersinger C, Goudreau JL, Sidhu A: Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. Faseb J. 2006, 20: 2302-2312. 10.1096/fj.06-6092com.
CAS
PubMed
Google Scholar
Hoglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Feger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC: The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem. 2005, 95: 930-939. 10.1111/j.1471-4159.2005.03493.x.
CAS
PubMed
Google Scholar
Wills J, Credle J, Oaks AW, Duka V, Lee JH, Jones J, Sidhu A: Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. PLoS One. 2012, 7: e30745-10.1371/journal.pone.0030745.
PubMed Central
CAS
PubMed
Google Scholar
Duka T, Duka V, Joyce JN, Sidhu A: Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models. Faseb J. 2009, 23: 2820-2830. 10.1096/fj.08-120410.
PubMed Central
CAS
PubMed
Google Scholar
Qureshi HY, Paudel HK: Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011, 286: 5055-5068. 10.1074/jbc.M110.178905.
PubMed Central
CAS
PubMed
Google Scholar
Morris M, Koyama A, Masliah E, Mucke L: Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PLoS One. 2011, 6: e29257-10.1371/journal.pone.0029257.
PubMed Central
CAS
PubMed
Google Scholar
Khandelwal PJ, Dumanis SB, Feng LR, Maguire-Zeiss K, Rebeck G, Lashuel HA, Moussa CE: Parkinson-related parkin reduces alpha-Synuclein phosphorylation in a gene transfer model. Mol Neurodegener. 2010, 5: 47-10.1186/1750-1326-5-47.
PubMed Central
PubMed
Google Scholar
Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE: Wild type and P301L mutant Tau promote neuro-inflammation and alpha-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci. 2012, 49: 44-53. 10.1016/j.mcn.2011.09.002.
PubMed Central
CAS
PubMed
Google Scholar
Klein RL, Dayton RD, Lin WL, Dickson DW: Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiol Dis. 2005, 20: 64-73. 10.1016/j.nbd.2005.02.001.
PubMed Central
CAS
PubMed
Google Scholar
Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M: Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002, 22: 9340-9351.
CAS
PubMed
Google Scholar
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M: Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet. 2000, 25: 402-405. 10.1038/78078.
CAS
PubMed
Google Scholar
Le Corre S, Klafki HW, Plesnila N, Hubinger G, Obermeier A, Sahagun H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, Roder HM: An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proc Natl Acad Sci U S A. 2006, 103: 9673-9678. 10.1073/pnas.0602913103.
PubMed Central
CAS
PubMed
Google Scholar
Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM: Initiation and synergistic fibrillization of tau and alpha-synuclein. Science. 2003, 300: 636-640. 10.1126/science.1082324.
CAS
PubMed
Google Scholar
Haggerty T, Credle J, Rodriguez O, Wills J, Oaks AW, Masliah E, Sidhu A: Hyperphosphorylated Tau in an alpha-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci. 2011, 33: 1598-1610. 10.1111/j.1460-9568.2011.07660.x.
PubMed Central
PubMed
Google Scholar
Kaul T, Credle J, Haggerty T, Oaks AW, Masliah E, Sidhu A: Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. BMC Neurosci. 2011, 12: 79-10.1186/1471-2202-12-79.
PubMed Central
CAS
PubMed
Google Scholar
Magen I, Chesselet MF: Mouse models of cognitive deficits due to alpha-synuclein pathology. J Parkinsons Dis. 2011, 1: 217-227.
CAS
PubMed
Google Scholar
Emmer KL, Waxman EA, Covy JP, Giasson BI: E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J Biol Chem. 2011, 286: 35104-35118. 10.1074/jbc.M111.247965.
PubMed Central
CAS
PubMed
Google Scholar
Wills J, Credle J, Haggerty T, Lee JH, Oaks AW, Sidhu A: Tauopathic changes in the striatum of A53T alpha-synuclein mutant mouse model of Parkinson's disease. PLoS One. 2011, 6: e17953-10.1371/journal.pone.0017953.
PubMed Central
CAS
PubMed
Google Scholar
Oaks AW, Frankfurt M, Finkelstein DI, Sidhu A: Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS One. 2013, 8: e60378-10.1371/journal.pone.0060378.
PubMed Central
CAS
PubMed
Google Scholar
Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, Kahle P, Wolozin B: Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein. Exp Neurol. 2005, 192: 274-287. 10.1016/j.expneurol.2004.07.016.
CAS
PubMed
Google Scholar
Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM: Synergistic interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010, 30: 7281-7289. 10.1523/JNEUROSCI.0490-10.2010.
PubMed Central
CAS
PubMed
Google Scholar
Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, Hynes M, Phillips H, Sulzer D, Rosenthal A: Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000, 25: 239-252. 10.1016/S0896-6273(00)80886-7.
CAS
PubMed
Google Scholar
Avila J, de Barreda EG, Fuster-Matanzo A, Simon D, Llorens-Martin M, Engel T, Lucas JJ, Diaz-Hernandez M, Hernandez F: Looking for novel functions of tau. Biochem Soc Trans. 2012, 40: 653-655. 10.1042/BST20120006.
CAS
PubMed
Google Scholar
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, Sato-Yoshitake R, Takei Y, Noda T, Hirokawa N: Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 1994, 369: 488-491. 10.1038/369488a0.
CAS
PubMed
Google Scholar
Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L: Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiol Aging. 2013, 34: 1523-1529. 10.1016/j.neurobiolaging.2012.12.003.
PubMed Central
CAS
PubMed
Google Scholar
Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, Duce JA, Bush AI: Tau deficiency induces Parkinsonism with dementia by impairing APP-mediated iron export. Nat Med. 2012, 18: 291-295. 10.1038/nm.2613.
CAS
PubMed
Google Scholar
Dawson TM, Ko HS, Dawson VL: Genetic animal models of Parkinson's disease. Neuron. 2010, 66: 646-661. 10.1016/j.neuron.2010.04.034.
PubMed Central
CAS
PubMed
Google Scholar
Prussing K, Voigt A, Schulz JB: Drosophila melanogaster as a model organism for Alzheimer's disease. Mol Neurodegener. 2013, 8: 35-10.1186/1750-1326-8-35.
PubMed Central
PubMed
Google Scholar
Teschendorf D, Link CD: What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?. Mol Neurodegener. 2009, 4: 38-10.1186/1750-1326-4-38.
PubMed Central
PubMed
Google Scholar
Feany MB, Bender WW: A Drosophila model of Parkinson's disease. Nature. 2000, 404: 394-398. 10.1038/35006074.
CAS
PubMed
Google Scholar
Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM: Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 2002, 295: 865-868. 10.1126/science.1067389.
CAS
PubMed
Google Scholar
Roy B, Jackson GR: Interactions between Tau and alpha-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease. Hum Mol Genet. 2014, ᅟ: ᅟ-
Google Scholar
Ciaccioli G, Martins A, Rodrigues C, Vieira H, Calado P: A powerful yeast model to investigate the synergistic interaction of alpha-synuclein and tau in neurodegeneration. PLoS One. 2013, 8: e55848-10.1371/journal.pone.0055848.
PubMed Central
CAS
PubMed
Google Scholar
Vandebroek T, Terwel D, Vanhelmont T, Gysemans M, Van Haesendonck C, Engelborghs Y, Winderickx J, Van Leuven F: Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5. J Biol Chem. 2006, 281: 25388-25397. 10.1074/jbc.M602792200.
CAS
PubMed
Google Scholar
Zabrocki P, Pellens K, Vanhelmont T, Vandebroek T, Griffioen G, Wera S, Van Leuven F, Winderickx J: Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast. Febs J. 2005, 272: 1386-1400. 10.1111/j.1742-4658.2005.04571.x.
CAS
PubMed
Google Scholar
Hamilton BA: alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates. Genomics. 2004, 83: 739-742. 10.1016/j.ygeno.2003.09.016.
CAS
PubMed
Google Scholar
Larsen K, Hedegaard C, Bertelsen MF, Bendixen C: Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals. Biochem Biophys Res Commun. 2009, 387: 602-605. 10.1016/j.bbrc.2009.07.070.
CAS
PubMed
Google Scholar
Arendt T, Stieler J, Strijkstra AM, Hut RA, Rudiger J, Van der Zee EA, Harkany T, Holzer M, Hartig W: Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. J Neurosci. 2003, 23: 6972-6981.
CAS
PubMed
Google Scholar
Yanagisawa M, Planel E, Ishiguro K, Fujita SC: Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease. FEBS Lett. 1999, 461: 329-333. 10.1016/S0014-5793(99)01480-5.
CAS
PubMed
Google Scholar
Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R: alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem. 1999, 274: 25481-25489. 10.1074/jbc.274.36.25481.
CAS
PubMed
Google Scholar
Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Goncalves SA, Pera M, Suarez-Calvet M, Clarimon J, Outeiro TF, Lleo A: Tau enhances alpha-synuclein aggregation and toxicity in cellular models of synucleinopathy. PLoS One. 2011, 6: e26609-10.1371/journal.pone.0026609.
PubMed Central
CAS
PubMed
Google Scholar
Esposito A, Dohm CP, Kermer P, Bahr M, Wouters FS: alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton. Neurobiol Dis. 2007, 26: 521-531. 10.1016/j.nbd.2007.01.014.
CAS
PubMed
Google Scholar
Benussi L, Ghidoni R, Paterlini A, Nicosia F, Alberici AC, Signorini S, Barbiero L, Binetti G: Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation. Exp Cell Res. 2005, 308: 78-84. 10.1016/j.yexcr.2005.04.021.
CAS
PubMed
Google Scholar
Koo HJ, Lee HJ, Im H: Sequence determinants regulating fibrillation of human alpha-synuclein. Biochem Biophys Res Commun. 2008, 368: 772-778. 10.1016/j.bbrc.2008.01.140.
CAS
PubMed
Google Scholar
Kawakami F, Suzuki M, Shimada N, Kagiya G, Ohta E, Tamura K, Maruyama H, Ichikawa T: Stimulatory effect of alpha-synuclein on the tau-phosphorylation by GSK-3beta. Febs J. 2011, 278: 4895-4904. 10.1111/j.1742-4658.2011.08389.x.
CAS
PubMed
Google Scholar
Bailey RM, Covy JP, Melrose HL, Rousseau L, Watkinson R, Knight J, Miles S, Farrer MJ, Dickson DW, Giasson BI, Lewis J: LRRK2 phosphorylates novel tau epitopes and promotes tauopathy. Acta Neuropathol. 2013, 126: 809-827. 10.1007/s00401-013-1188-4.
PubMed Central
CAS
PubMed
Google Scholar
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F: LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS One. 2012, 7: e30834-10.1371/journal.pone.0030834.
PubMed Central
CAS
PubMed
Google Scholar
Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, Glatza M, Hoing S, Hargus G, Heck SA, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer HR, Sterneckert J: Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Cell Stem Cell. 2013, 12: 354-367. 10.1016/j.stem.2013.01.008.
CAS
PubMed
Google Scholar
Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B: alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J Neurosci. 1999, 19: 5782-5791.
CAS
PubMed
Google Scholar
Hashiguchi M, Sobue K, Paudel HK: 14-3-3zeta is an effector of tau protein phosphorylation. J Biol Chem. 2000, 275: 25247-25254. 10.1074/jbc.M003738200.
CAS
PubMed
Google Scholar
Alim MA, Hossain MS, Arima K, Takeda K, Izumiyama Y, Nakamura M, Kaji H, Shinoda T, Hisanaga S, Ueda K: Tubulin seeds alpha-synuclein fibril formation. J Biol Chem. 2002, 277: 2112-2117. 10.1074/jbc.M102981200.
CAS
PubMed
Google Scholar
Alim MA, Ma QL, Takeda K, Aizawa T, Matsubara M, Nakamura M, Asada A, Saito T, Kaji H, Yoshii M, Hisanaga S, Ueda K: Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein. J Alzheimers Dis. 2004, 6: 435-442. discussion 443-439
PubMed
Google Scholar
Zhou Y, Gu G, Goodlett DR, Zhang T, Pan C, Montine TJ, Montine KS, Aebersold RH, Zhang J: Analysis of alpha-synuclein-associated proteins by quantitative proteomics. J Biol Chem. 2004, 279: 39155-39164. 10.1074/jbc.M405456200.
CAS
PubMed
Google Scholar
Wersinger C, Sidhu A: Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter. Biochemistry. 2005, 44: 13612-13624. 10.1021/bi050402p.
CAS
PubMed
Google Scholar
Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm KJ, Winner B: alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem. 2013, 288: 21742-21754. 10.1074/jbc.M113.451815.
PubMed Central
CAS
PubMed
Google Scholar
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW: Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med. 2008, 14: 504-506. 10.1038/nm1747.
CAS
PubMed
Google Scholar
Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Bjorklund A, Widner H, Revesz T, Lindvall O, Brundin P: Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med. 2008, 14: 501-503. 10.1038/nm1746.
CAS
PubMed
Google Scholar
Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M: Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc Natl Acad Sci U S A. 2013, 110: 9535-9540. 10.1073/pnas.1301175110.
PubMed Central
CAS
PubMed
Google Scholar
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M: Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009, 11: 909-913. 10.1038/ncb1901.
PubMed Central
CAS
PubMed
Google Scholar
Clavaguera F, Hench J, Lavenir I, Schweighauser G, Frank S, Goedert M, Tolnay M: Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice. Acta Neuropathol. 2014, 127: 299-301. 10.1007/s00401-013-1231-5.
PubMed Central
PubMed
Google Scholar
Danzer KM, Haasen D, Karow AR, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B, Kostka M: Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci. 2007, 27: 9220-9232. 10.1523/JNEUROSCI.2617-07.2007.
CAS
PubMed
Google Scholar
Danzer KM, Krebs SK, Wolff M, Birk G, Hengerer B: Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology. J Neurochem. 2009, 111: 192-203. 10.1111/j.1471-4159.2009.06324.x.
CAS
PubMed
Google Scholar
Frost B, Jacks RL, Diamond MI: Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 2009, 284: 12845-12852. 10.1074/jbc.M808759200.
PubMed Central
CAS
PubMed
Google Scholar
Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM: Distinct alpha-synuclein strains differentially promote tau inclusions in neurons. Cell. 2013, 154: 103-117. 10.1016/j.cell.2013.05.057.
CAS
PubMed
Google Scholar
Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM: Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci. 2013, 33: 1024-1037. 10.1523/JNEUROSCI.2642-12.2013.
PubMed Central
CAS
PubMed
Google Scholar
Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM: Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 2011, 72: 57-71. 10.1016/j.neuron.2011.08.033.
PubMed Central
CAS
PubMed
Google Scholar
Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB: Transmission of multiple system atrophy prions to transgenic mice. Proc Natl Acad Sci U S A. 2013, 110: 19555-19560. 10.1073/pnas.1318268110.
PubMed Central
CAS
PubMed
Google Scholar
Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, Vanderburg CR, McLean PJ: Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener. 2012, 7: 42-10.1186/1750-1326-7-42.
PubMed Central
CAS
PubMed
Google Scholar
Simon D, Garcia-Garcia E, Royo F, Falcon-Perez JM, Avila J: Proteostasis of tau: Tau overexpression results in its secretion via membrane vesicles. FEBS Lett. 2012, 586: 47-54. 10.1016/j.febslet.2011.11.022.
CAS
PubMed
Google Scholar
Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA: Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature. 1996, 383: 550-553. 10.1038/383550a0.
CAS
PubMed
Google Scholar
Nubling G, Bader B, Levin J, Hildebrandt J, Kretzschmar H, Giese A: Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level. Mol Neurodegener. 2012, 7: 35-10.1186/1750-1326-7-35.
PubMed Central
PubMed
Google Scholar
Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM: Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science. 2012, 338: 949-953. 10.1126/science.1227157.
PubMed Central
CAS
PubMed
Google Scholar
Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M: Prion-like spreading of pathological alpha-synuclein in brain. Brain. 2013, 136: 1128-1138. 10.1093/brain/awt037.
PubMed Central
PubMed
Google Scholar
Waxman EA, Giasson BI: Induction of intracellular tau aggregation is promoted by alpha-synuclein seeds and provides novel insights into the hyperphosphorylation of tau. J Neurosci. 2011, 31: 7604-7618. 10.1523/JNEUROSCI.0297-11.2011.
PubMed Central
CAS
PubMed
Google Scholar
Brown P, Gajdusek DC, Gibbs CJ, Asher DM: Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy. N Engl J Med. 1985, 313: 728-731. 10.1056/NEJM198509193131205.
CAS
PubMed
Google Scholar
Irwin DJ, Abrams JY, Schonberger LB, Leschek EW, Mills JL, Lee VM, Trojanowski JQ: Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone. JAMA Neurol. 2013, 70: 462-468. 10.1001/jamaneurol.2013.1933.
PubMed Central
PubMed
Google Scholar
David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG: Proteasomal degradation of tau protein. J Neurochem. 2002, 83: 176-185. 10.1046/j.1471-4159.2002.01137.x.
CAS
PubMed
Google Scholar
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M: CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet. 2004, 13: 703-714. 10.1093/hmg/ddh083.
CAS
PubMed
Google Scholar
Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI: Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. 2011, 50: 10300-10310. 10.1021/bi2009147.
PubMed Central
CAS
PubMed
Google Scholar
Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ: Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. J Biol Chem. 2004, 279: 25497-25502. 10.1074/jbc.M400255200.
CAS
PubMed
Google Scholar
McFarland NR, Dimant H, Kibuuka L, Ebrahimi-Fakhari D, Desjardins CA, Danzer KM, Danzer M, Fan Z, Schwarzschild MA, Hirst W, McLean PJ: Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not alpha-synuclein-induced neuronal cell loss. PLoS One. 2014, 9: e86048-10.1371/journal.pone.0086048.
PubMed Central
PubMed
Google Scholar
McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT: TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J Neurochem. 2002, 83: 846-854. 10.1046/j.1471-4159.2002.01190.x.
CAS
PubMed
Google Scholar
McLean PJ, Klucken J, Shin Y, Hyman BT: Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro. Biochem Biophys Res Commun. 2004, 321: 665-669. 10.1016/j.bbrc.2004.07.021.
CAS
PubMed
Google Scholar
Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ: Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochem Biophys Res Commun. 2006, 351: 631-638. 10.1016/j.bbrc.2006.10.085.
PubMed Central
CAS
PubMed
Google Scholar
Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ: Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. J Pharmacol Exp Ther. 2010, 332: 849-857. 10.1124/jpet.109.158436.
PubMed Central
CAS
PubMed
Google Scholar
Sharma N, Hewett J, Ozelius LJ, Ramesh V, McLean PJ, Breakefield XO, Hyman BT: A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am J Pathol. 2001, 159: 339-344. 10.1016/S0002-9440(10)61700-2.
PubMed Central
CAS
PubMed
Google Scholar
Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ: The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem. 2005, 280: 23727-23734. 10.1074/jbc.M503326200.
CAS
PubMed
Google Scholar
Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ: CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem. 2008, 283: 17962-17968. 10.1074/jbc.M802283200.
PubMed Central
CAS
PubMed
Google Scholar
Parnetti L, Castrioto A, Chiasserini D, Persichetti E, Tambasco N, El-Agnaf O, Calabresi P: Cerebrospinal fluid biomarkers in Parkinson disease. Nat Rev Neurol. 2013, 9: 131-140. 10.1038/nrneurol.2013.10.
CAS
PubMed
Google Scholar