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Table 1 Demographic, cognitive and pathological characteristicsa of MAP participants included in the present study

From: Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Variable All participants (n = 308) NCI (n = 90) MCI (n = 86) Dementia (n = 132)
Demographic     
Female, no. (%) 194 (63 %) 64 (71 %) 48 (56 %) 82 (62 %)
Age at death, years 88.8 ± 6.0 86.8 ± 6.3 88.1 ± 6.4 90.7 ± 5.0
Education, years 14.4 ± 2.8 14.0 ± 2.4 14.7 ± 2.5 14.5 ± 3.2
Race, no. W:AA:NA 300:7:1 86:4:0 84:1:1 130:2:0
APOE ε4 allele, no. (%) 84 (27 %) 15 (17 %) 22 (26 %) 47 (36 %)
PMI, hours 7.2 ± 4.8 6.9 ± 4.4 8.1 ± 5.5 6.7 ± 4.6
Cognitive function proximate to death     
Global cognition score −0.85 ± 1.09 0.16 ± 0.41 −0.43 ± 0.45 −1.83 ± 0.88
 Episodic memory −0.84 ± 1.19 0.34 ± 0.48 −0.55 ± 0.70 −1.84 ± 0.90
 Semantic memory −0.70 ± 1.23 0.12 ± 0.56 −0.19 ± 0.53 −1.61 ± 1.31
 Working memory −0.66 ± 1.14 0.16 ± 0.77 −0.29 ± 0.79 −1.50 ± 1.01
 Perceptual speed −1.13 ± 1.13 −0.28 ± 0.85 −0.70 ± 0.88 −2.02 ± 0.77
 Visuospatial ability −0.63 ± 1.23 0.12 ± 0.62 −0.16 ± 0.78 −1.49 ± 1.29
MMSE 21.3 ± 8.8 28.1 ± 1.8 25.7 ± 3.8 13.6 ± 8.2
Pathological     
NIA/Reagan scale, no. in 1:2:3:4b 49:135:120:4 4:25:59:2 4:44:36:2 41:66:25:0
CERAD scale, no. in 1:2:3:4c 95:99:40:74 13:21:19:37 19:31:13:23 63:47:8:14
Braak stage, no. in 0:I:II:III: 4:20:33:91: 2:14:16:33: 2:2:14:28: 0:4:3:30:
IV:V:VI 88: 67:5 21:4:0 30:10:0 37:53:5
Global AD pathology 0.69 ± 0.62 0.38 ± 0.39 0.60 ± 0.57 0.97 ± 0.66
Macroinfarcts, no. (%) 108 (35 %) 20 (22 %) 29 (34 %) 59 (45 %)
Microinfarcts, no. (%) 71 (23 %) 20 (22 %) 14 (16 %) 37 (28 %)
Lewy body disease, no. (%) 27 (9 %) 2 (2 %) 4 (5 %) 21 (16 %)
Hippocampal sclerosis, no. (%) 26 (8 %) 1 (1 %) 5 (6 %) 20 (15 %)
  1. Abbreviations: AA Afro-American, AD, Alzheimer’s disease, BL baseline, CERAD Consortium to establish a registry for AD, MCI mild cognitive impairment, MMSE mini mental state examination, NA Native-American, NCI no cognitive impairment, NIA National Institute on Aging, no number of subjects, PMI postmortem interval, SD standard deviation, W White
  2. aValues are mean ± SD unless noted otherwise
  3. bNIA/Reagan scale: high (1), intermediate (2), low (3), or no (4) likelihood of AD, according to neuritic plaques and tangles
  4. cCERAD scale: definite (1), possible (2), probable (3), or no (4) AD, according to neuritic plaques