Fig. 1

a Schematic representation of the main constitutive components of the microfluidic platform. b Photograph of the device, with schematic picture of the closed-loop temperature control system. c Section view of the device assembly, with a zoom on a microfluidic design within the imaging area. Scale bar = 2 mm. d Representative microfluidic geometries for use with the platform, featuring matrices of (i) 1, (ii) 4 and (iii) 32 worm culture chambers. Scale bars = 200 μm