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Table 1 Demographic, cognitive and pathological characteristicsa of MAP participants included in the present study

From: Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

Variable All participants (n = 150) NCI (n = 51) MCI (n = 42) Dementia (n = 57)
Demographic
 Female, no. (%) 105 (70%) 40 (78%) 27 (64%) 38 (67%)
 Age at death, years 88.7 ± 6.3 86.7 ± 6.7 88.1 ± 6.8 90.9 ± 4.7
 Education, years 14.6 ± 2.9 13.9 ± 2.5 15.0 ± 2.8 15.0 ± 3.3
 Race, no. W:AA 146:4 49:2 41:1 56:1
APOE ε4 carrier, no. (%) 33 (22%) 7 (14%) 11 (26%) 15 (26%)
 PMI, hours 6.6 ± 3.8 6.2 ± 2.1 7.6 ± 5.6 6.2 ± 3.1
Cognitive function proximate to death
 Global cognition score −0.77 ± 1.01 0.10 ± 0.39 −0.47 ± 0.43 −1.80 ± 0.78
 MMSE 21.9 ± 8.2 27.7 ± 1.9 24.9 ± 4.6 14.4 ± 8.1
Pathological
 Macroinfarcts, no (%)b 45 (30%) 10 (20%) 15 (36%) 20 (35%)
 Lewy bodies, no (%)b 25 (17%) 4 (8%) 1 (2%) 20 (35%)
 Hippocampal sclerosis, no (%)b 14 (9%) 0 (0%) 4 (10%) 10 (18%)
 Arteriolosclerosisb 1.39 ± 0.87 1.24 ± 0.84 1.38 ± 0.82 1.53 ± 0.93
 Amyloid plaquesc 5.3 ± 5.9 2.9 ± 3.3 5.5 ± 6.5 7.3 ± 6.5
 Tanglesc 1.1 ± 3.0 0.4 ± 1.7 1.1 ± 3.0 1.8 ± 3.7
  1. Abbreviations: AA Afro-American, AD Alzheimer’s disease, MAP Memory and Aging Project, MCI mild cognitive impairment, MMSE mini mental state examination, NCI, no cognitive impairment, PMI postmortem interval, SD standard deviation, W White
  2. aValues are mean ± SD unless noted otherwise
  3. bGlobal values
  4. cValues obtained in the contralateral dorsolateral prefrontal cortex (DLPFC) by immunohistochemistry with specific antibodies