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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia

Fig. 2

Reduced retinal function in aged coneΔVhl mice. a Averaged traces of single-flash photopic ERGs and b-wave amplitudes showed no significant differences in coneΔVhl mice (orange) compared to ctrl mice (black) at 6 weeks of age. b At 12 weeks of age, photopic b-wave amplitudes were strongly reduced in coneΔVhl mice (orange) as compared to ctrl mice (black). b-wave amplitudes are shown as means ± SD. Two-way ANOVA with Šídák’s multiple comparison test was used for statistical analysis (6we ctrl and coneΔVhl n=5, 12we ctrl n=6 and coneΔVhl n=4, *p=0.0115, ****p<0.0001)

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