Fig. 5

Methoxy-X04 (+) microglia isolated from App^SAA knock-in mice show alterations of lipids and metabolites levels. a-b Heatmap of (a) lipids and (b) metabolites significantly altered by genotype and/or presence of methoxy-X04 dye in microglia isolated from App^SAA KI/KI and App^SAA +/+ mouse brain. n=10, columns represent individual mice. c Representative plots showing genotype and methoxy-X04 effects on key lipids and metabolites from FACS-isolated microglia. n=10. Statistical analysis was performed by fitting linear models using limma; FDR was calculated according to Benjamini’s and Hochberg’s method. All panels from a-c are showing data from 8-month-old mice