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  3. The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis. Despite the extensive use ...

    Authors: Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello and Jason R. Plemel
    Citation: Molecular Neurodegeneration 2022 17:34
    Content type: Review Published on:

  4. The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regula...

    Authors: Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran…
    Citation: Molecular Neurodegeneration 2022 17:33
    Content type: Research article Published on:

  5. Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function...

    Authors: A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam and Stephen M. Strittmatter
    Citation: Molecular Neurodegeneration 2022 17:32
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2022 17:56

  6. Alzheimer’s disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressive cognitive decline. Despite decades of research effective therapies are lacking, and a larg...

    Authors: Liene Bossaerts, Rita Cacace and Christine Van Broeckhoven
    Citation: Molecular Neurodegeneration 2022 17:31
    Content type: Review Published on:

  7. Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly under...

    Authors: Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis…
    Citation: Molecular Neurodegeneration 2022 17:30
    Content type: Research article Published on:

  8. Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients w...

    Authors: Alba Cervantes González, David J. Irwin, Daniel Alcolea, Corey T. McMillan, Alice Chen-Plotkin, David Wolk, Sònia Sirisi, Oriol Dols-Icardo, Marta Querol-Vilaseca, Ignacio Illán-Gala, Miguel Angel Santos-Santos, Juan Fortea, Edward B. Lee, John Q. Trojanowski, Murray Grossman, Alberto Lleó…
    Citation: Molecular Neurodegeneration 2022 17:29
    Content type: Research article Published on:

  9. Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions.

    Authors: Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong and Jin-Tai Yu
    Citation: Molecular Neurodegeneration 2022 17:28
    Content type: Review Published on:

  10. Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be increased in very ...

    Authors: Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich…
    Citation: Molecular Neurodegeneration 2022 17:27
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2022 17:37

  11. Microglia, the resident immune cells of the brain, play a critical role in numerous diseases, but are a minority cell type and difficult to genetically manipulate in vivo with viral vectors and other approache...

    Authors: Mika P. Cadiz, Tanner D. Jensen, Jonathon P. Sens, Kuixi Zhu, Won-Min Song, Bin Zhang, Mark Ebbert, Rui Chang and John D. Fryer
    Citation: Molecular Neurodegeneration 2022 17:26
    Content type: Research article Published on:

  12. The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and rapid prot...

    Authors: Todd McLaughlin, Andy Medina, Jacob Perkins, Maria Yera, Joshua J. Wang and Sarah X. Zhang
    Citation: Molecular Neurodegeneration 2022 17:25
    Content type: Review Published on:

  14. Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address...

    Authors: Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan…
    Citation: Molecular Neurodegeneration 2022 17:23
    Content type: Review Published on:

  15. Neuroinflammation is an important hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). An inflammatory reaction to neuronal injury is deemed vital for neuronal health a...

    Authors: Pegah Masrori, Jimmy Beckers, Helena Gossye and Philip Van Damme
    Citation: Molecular Neurodegeneration 2022 17:22
    Content type: Review Published on:

  18. The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept. Accumulating data suggest that the gut microbiota exert its action at least in ...

    Authors: Diane Bairamian, Sha Sha, Nathalie Rolhion, Harry Sokol, Guillaume Dorothée, Cynthia A. Lemere and Slavica Krantic
    Citation: Molecular Neurodegeneration 2022 17:19
    Content type: Review Published on:

  20. Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic studies have revealed biomarkers, risk fact...

    Authors: Minghui Wang, Won-min Song, Chen Ming, Qian Wang, Xianxiao Zhou, Peng Xu, Azra Krek, Yonejung Yoon, Lap Ho, Miranda E. Orr, Guo-Cheng Yuan and Bin Zhang
    Citation: Molecular Neurodegeneration 2022 17:17
    Content type: Review Published on:

  21. Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD). We previously showed that MC1R signaling can facilitate n...

    Authors: Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild and Xiqun Chen
    Citation: Molecular Neurodegeneration 2022 17:16
    Content type: Research article Published on:

  22. Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lyso...

    Authors: Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel and Fenghua Hu
    Citation: Molecular Neurodegeneration 2022 17:15
    Content type: Research article Published on:

  23. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13024-021-00438-3.

    Authors: Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang and Hussein N. Yassine
    Citation: Molecular Neurodegeneration 2022 17:14
    Content type: Retraction Note Published on:

  24. One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for la...

    Authors: Thomas E. Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich and David M. Holtzman
    Citation: Molecular Neurodegeneration 2022 17:13
    Content type: Research article Published on:

  25. The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive. The inciden...

    Authors: Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong and Zhentao Zhang
    Citation: Molecular Neurodegeneration 2022 17:12
    Content type: Research article Published on:

  26. Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in which many processes are detected including (neuro)inflammation. Many drugs have been tested for ALS in clinical trials but mos...

    Authors: Kim A. Staats, David R. Borchelt, Malú Gámez Tansey and James Wymer
    Citation: Molecular Neurodegeneration 2022 17:11
    Content type: Review Published on:

  27. The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7,...

    Authors: Tarin M. Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel, Carlos Cruchaga, Wayne M. Yokoyama and David M. Holtzman
    Citation: Molecular Neurodegeneration 2022 17:10
    Content type: Research article Published on:

  28. Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer’s disease (AD). The role of pericyte in early stage of AD pathogenesis remains unclear.

    Authors: Jun Wang, Dong-Yu Fan, Hui-Yun Li, Chen-Yang He, Ying-Ying Shen, Gui-Hua Zeng, Dong-Wan Chen, Xu Yi, Ya-Hui Ma, Jin-Tai Yu and Yan-Jiang Wang
    Citation: Molecular Neurodegeneration 2022 17:9
    Content type: Research article Published on:

  29. Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenera...

    Authors: Qian Li, Yi Feng, Yingchao Xue, Xiping Zhan, Yi Fu, Gege Gui, Weiqiang Zhou, Jean-Philippe Richard, Arens Taga, Pan Li, Xiaobo Mao, Nicholas J. Maragakis and Mingyao Ying
    Citation: Molecular Neurodegeneration 2022 17:8
    Content type: Research article Published on:

  30. Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression i...

    Authors: Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert and Andrew B. West
    Citation: Molecular Neurodegeneration 2022 17:7
    Content type: Research article Published on:

  31. Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising c...

    Authors: Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng…
    Citation: Molecular Neurodegeneration 2022 17:6
    Content type: Research article Published on:

  32. Cellular senescence is a complex stress response that impacts cellular function and organismal health. Multiple developmental and environmental factors, such as intrinsic cellular cues, radiation, oxidative st...

    Authors: Peng Xu, Minghui Wang, Won-min Song, Qian Wang, Guo-Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr and Bin Zhang
    Citation: Molecular Neurodegeneration 2022 17:5
    Content type: Research article Published on:

  33. There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical role in disease onset and progr...

    Authors: Luting Poh, Wei Liang Sim, Dong-Gyu Jo, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Christopher Li-Hsian Chen, Mitchell K. P. Lai, David Y. Fann and Thiruma V. Arumugam
    Citation: Molecular Neurodegeneration 2022 17:4
    Content type: Review Published on:

  34. The search for rare variants in Alzheimer’s disease (AD) is usually deemed a high-risk - high-reward situation. The challenges associated with this endeavor are real. Still, the application of genome-wide tech...

    Authors: Marzieh Khani, Elizabeth Gibbons, Jose Bras and Rita Guerreiro
    Citation: Molecular Neurodegeneration 2022 17:3
    Content type: Review Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2022 17:70

  35. The use of animals as models of human physiology is, and has been for many years, an indispensable tool for understanding the mechanisms of human disease. In Parkinson’s disease, various mouse models form the ...

    Authors: Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic and Oliver Rawashdeh
    Citation: Molecular Neurodegeneration 2022 17:2
    Content type: Review Published on:

  36. In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish au...

    Authors: A. Joseph Bloom, Xianrong Mao, Amy Strickland, Yo Sasaki, Jeffrey Milbrandt and Aaron DiAntonio
    Citation: Molecular Neurodegeneration 2022 17:1
    Content type: Research article Published on:

  37. Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and thus, the regulation of gene exp...

    Authors: Axel Meneses, Shunsuke Koga, Justin O’Leary, Dennis W. Dickson, Guojun Bu and Na Zhao
    Citation: Molecular Neurodegeneration 2021 16:84
    Content type: Review Published on:

  38. Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytopl...

    Authors: Shunsuke Koga, Hiroaki Sekiya, Naveen Kondru, Owen A. Ross and Dennis W. Dickson
    Citation: Molecular Neurodegeneration 2021 16:83
    Content type: Review Published on:

  39. Detection of the pathological and disease-associated alpha-synuclein (αSynD) in the brain is required to formulate the definitive diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD). We recent...

    Authors: Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong Xu, Steven Alexander Gunzler, Giorgio Giaccone…
    Citation: Molecular Neurodegeneration 2021 16:82
    Content type: Research article Published on:

  40. Neurodegenerative disorders are a group of age-associated diseases characterized by progressive degeneration of the structure and function of the CNS. Two key pathological features of these disorders are blood...

    Authors: Benjamin Nguyen, Gregory Bix and Yao Yao
    Citation: Molecular Neurodegeneration 2021 16:81
    Content type: Review Published on:

  41. MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level c...

    Authors: Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik…
    Citation: Molecular Neurodegeneration 2021 16:80
    Content type: Research article Published on:

  42. A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the ...

    Authors: Sofia Bergström, Linn Öijerstedt, Julia RemnestÃ¥l, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C. van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Laforce, Daniela Galimberti…
    Citation: Molecular Neurodegeneration 2021 16:79
    Content type: Research article Published on:

  43. Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphor...

    Authors: Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan and Georgette D. Kanmogne
    Citation: Molecular Neurodegeneration 2021 16:78
    Content type: Research article Published on:

  44. Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Pa...

    Authors: Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler…
    Citation: Molecular Neurodegeneration 2021 16:77
    Content type: Research article Published on:

  45. Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA resear...

    Authors: Hannah Walgrave, Lujia Zhou, Bart De Strooper and Evgenia Salta
    Citation: Molecular Neurodegeneration 2021 16:76
    Content type: Perspective Published on:

  46. Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden ...

    Authors: Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett and Philip L. De Jager
    Citation: Molecular Neurodegeneration 2021 16:75
    Content type: Research article Published on:

  48. Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behav...

    Authors: Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding and Youming Lu
    Citation: Molecular Neurodegeneration 2021 16:73
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Neurodegeneration 2023 18:33

  50. Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophi...

    Authors: Silvia Bono, Marco Feligioni and Massimo Corbo
    Citation: Molecular Neurodegeneration 2021 16:71
    Content type: Review Published on:
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  • ISSN: 1750-1326 (electronic)

Molecular Neurodegeneration

ISSN: 1750-1326