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  1. Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β pept...

    Authors: Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami and Toshiharu Suzuki
    Citation: Molecular Neurodegeneration 2012 7:16
    Content type: Research article Published on:

  2. Abnormal proteostasis due to alterations in protein turnover has been postulated to play a central role in several neurodegenerative diseases. Therefore, the development of techniques to quantify protein turno...

    Authors: Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman and David M Holtzman
    Citation: Molecular Neurodegeneration 2012 7:14
    Content type: Methodology Published on:

  3. Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may...

    Authors: Mariet Allen, Fanggeng Zou, High Seng Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak…
    Citation: Molecular Neurodegeneration 2012 7:13
    Content type: Research article Published on:

  4. No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Cu...

    Authors: Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine and Marie-Françoise Chesselet
    Citation: Molecular Neurodegeneration 2012 7:12
    Content type: Research article Published on:

  5. Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. Neurotrophin receptors are active in signaling endosomes, whi...

    Authors: Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo and Francisca C Bronfman
    Citation: Molecular Neurodegeneration 2012 7:11
    Content type: Research article Published on:

  6. Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease characterized by the loss of motor function. Several ALS genes have been identified as their mutations can lead to familial ALS, inc...

    Authors: Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu and Jianhang Jia
    Citation: Molecular Neurodegeneration 2012 7:10
    Content type: Research article Published on:

  7. Several studies found that FE65, a cytoplasmic adaptor protein, interacts with APP and LRP1, altering the trafficking and processing of APP. We have previously shown that FE65 interacts with the ApoE receptor,...

    Authors: Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guénette, Toshiharu Suzuki, Paul M Mathews, Daniel TS Pak, G William Rebeck, Yoo-hun Suh, Hee-Sae Park and Hyang-Sook Hoe
    Citation: Molecular Neurodegeneration 2012 7:9
    Content type: Research article Published on:

  8. The form(s) of amyloid-β peptide (Aβ) associated with the pathology characteristic of Alzheimer's disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an issue of ...

    Authors: Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine Jr, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley and Mary Jo LaDu
    Citation: Molecular Neurodegeneration 2012 7:8
    Content type: Research article Published on:

  9. Retinal degenerations, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), are characterized by photoreceptor loss and anomalous remodeling of the surviving retina that corrupts visua...

    Authors: Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell and Robert E Marc
    Citation: Molecular Neurodegeneration 2012 7:7
    Content type: Research article Published on:

  10. A mechanical trauma to the spinal cord can be followed by the development of irreversible and progressive neurodegeneration, as opposed to a temporary or partially reversible neurological damage. An increasing...

    Authors: Ping K Yip and Andrea Malaspina
    Citation: Molecular Neurodegeneration 2012 7:6
    Content type: Review Published on:
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  • ISSN: 1750-1326 (electronic)

Molecular Neurodegeneration

ISSN: 1750-1326