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  1. MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level c...

    Authors: Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik…

    Citation: Molecular Neurodegeneration 2021 16:80

    Content type: Research article

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  2. A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the ...

    Authors: Sofia Bergström, Linn Öijerstedt, Julia Remnestål, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C. van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Laforce, Daniela Galimberti…

    Citation: Molecular Neurodegeneration 2021 16:79

    Content type: Research article

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  3. Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphor...

    Authors: Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan and Georgette D. Kanmogne

    Citation: Molecular Neurodegeneration 2021 16:78

    Content type: Research article

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  4. Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Pa...

    Authors: Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler…

    Citation: Molecular Neurodegeneration 2021 16:77

    Content type: Research article

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  5. Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA resear...

    Authors: Hannah Walgrave, Lujia Zhou, Bart De Strooper and Evgenia Salta

    Citation: Molecular Neurodegeneration 2021 16:76

    Content type: Perspective

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  6. Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden ...

    Authors: Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett and Philip L. De Jager

    Citation: Molecular Neurodegeneration 2021 16:75

    Content type: Research article

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  7. Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behav...

    Authors: Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding and Youming Lu

    Citation: Molecular Neurodegeneration 2021 16:73

    Content type: Research article

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  8. Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophi...

    Authors: Silvia Bono, Marco Feligioni and Massimo Corbo

    Citation: Molecular Neurodegeneration 2021 16:71

    Content type: Review

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  9. N6-methyladenosine (m6A) modification of RNA influences fundamental aspects of RNA metabolism and m6A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m6

    Authors: Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L. Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang, James M. O’Donnell, Beisha Tang and Xiongwei Zhu

    Citation: Molecular Neurodegeneration 2021 16:70

    Content type: Research article

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  10. Contrasting with zebrafish, retinal regeneration from Müller cells (MCs) is largely limited in mammals, where they undergo reactive gliosis that consist of a hypertrophic response and ultimately results in vis...

    Authors: Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp and Volker Enzmann

    Citation: Molecular Neurodegeneration 2021 16:69

    Content type: Research article

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  11. Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer’s disease comes from molecular and functional studies in rodent models. Howeve...

    Authors: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison M Goate, Bart De Strooper and Amaia M Arranz

    Citation: Molecular Neurodegeneration 2021 16:68

    Content type: Methodology

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  12. Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribut...

    Authors: Qingyang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiaolin Ma, Chao Wang, Keqiang He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu and Qiang Liu

    Citation: Molecular Neurodegeneration 2021 16:66

    Content type: Research article

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  13. In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis. In the context of Alzheimer’s disease, misfolded ...

    Authors: Artemis Iatrou, Eric M. Clark and Yanling Wang

    Citation: Molecular Neurodegeneration 2021 16:65

    Content type: Review

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  14. Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests...

    Authors: Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree and Xianlin Han

    Citation: Molecular Neurodegeneration 2021 16:64

    Content type: Research article

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  15. The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Lewy body...

    Authors: Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson and David R. Borchelt

    Citation: Molecular Neurodegeneration 2021 16:63

    Content type: Research article

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  16. Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest...

    Authors: Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T. Smith, J. Anthony Brandon…

    Citation: Molecular Neurodegeneration 2021 16:62

    Content type: Research article

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  17. Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likel...

    Authors: Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz and Luc Dupuis

    Citation: Molecular Neurodegeneration 2021 16:61

    Content type: Research article

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  18. MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through thei...

    Authors: Joshua A. Chu-Tan, Adrian V. Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis and Riccardo Natoli

    Citation: Molecular Neurodegeneration 2021 16:60

    Content type: Research article

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  19. In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer’s disease (LOAD) and translate the associations to causation.

    Authors: Julio Barrera, Lingyun Song, Julia E. Gamache, Melanie E. Garrett, Alexias Safi, Young Yun, Ivana Premasinghe, Daniel Sprague, Danielle Chipman, Jeffrey Li, Hélène Fradin, Karen Soldano, Raluca Gordân, Allison E. Ashley-Koch, Gregory E. Crawford and Ornit Chiba-Falek

    Citation: Molecular Neurodegeneration 2021 16:58

    Content type: Research article

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  20. Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies. Multiple studies have suggeste...

    Authors: Dah-eun Chloe Chung, Shanu Roemer, Leonard Petrucelli and Dennis W. Dickson

    Citation: Molecular Neurodegeneration 2021 16:57

    Content type: Review

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  21. Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer’s disease (AD). Here we review the advances and limitations in historic an...

    Authors: Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang and Junmin Peng

    Citation: Molecular Neurodegeneration 2021 16:55

    Content type: Review

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    The Correction to this article has been published in Molecular Neurodegeneration 2021 16:72

  22. Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ...

    Authors: Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle…

    Citation: Molecular Neurodegeneration 2021 16:54

    Content type: Research article

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  23. Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identific...

    Authors: Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo…

    Citation: Molecular Neurodegeneration 2021 16:53

    Content type: Research article

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  24. Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an urgent need to identify biomarkers to tackle the disea...

    Authors: Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorarù, Christian Lunetta…

    Citation: Molecular Neurodegeneration 2021 16:52

    Content type: Research article

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  25. Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is prot...

    Authors: Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson and Aimee W. Kao

    Citation: Molecular Neurodegeneration 2021 16:51

    Content type: Research article

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  26. Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering rec...

    Authors: Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan and Mathew Blurton-Jones

    Citation: Molecular Neurodegeneration 2021 16:50

    Content type: Short report

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  27. Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive decline and dementia onset by intervening before significant neuronal damage occurs. In recent years, the first AD preven...

    Authors: Eric McDade, Jorge J. Llibre-Guerra, David M. Holtzman, John C. Morris and Randall J. Bateman

    Citation: Molecular Neurodegeneration 2021 16:49

    Content type: Review

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  28. Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the curre...

    Authors: Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Yang Chen, Xian Chen, Ying Li, Yuan Cen, Cheng Xu, Tian Hu, Xu-Dong Liu, Ling-Li Yang, Si-Jing Li, Xue-Fei Liu, Chun-Mei Liu, Jie Zhu, Wei Li…

    Citation: Molecular Neurodegeneration 2021 16:48

    Content type: Research article

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  29. Microglia are active modulators of Alzheimer’s disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relations...

    Authors: Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper…

    Citation: Molecular Neurodegeneration 2021 16:47

    Content type: Research article

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  30. Human tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neur...

    Authors: Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini and Dagmar E. Ehrnhoefer

    Citation: Molecular Neurodegeneration 2021 16:46

    Content type: Research article

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  31. Neuritic plaques in Alzheimer’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form ...

    Authors: Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido and Riqiang Yan

    Citation: Molecular Neurodegeneration 2021 16:45

    Content type: Research article

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  32. The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative disease...

    Authors: Nicolas Belforte, Jessica Agostinone, Luis Alarcon-Martinez, Deborah Villafranca-Baughman, Florence Dotigny, Jorge L. Cueva Vargas and Adriana Di Polo

    Citation: Molecular Neurodegeneration 2021 16:43

    Content type: Research article

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  33. There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying mole...

    Authors: Laura Gutierrez-Quiceno, Eric B. Dammer, Ashlyn Grace Johnson, James A. Webster, Rhythm Shah, Duc Duong, Luming Yin, Nicholas T. Seyfried, Victor E. Alvarez, Thor D. Stein, Ann C. McKee and Chadwick M. Hales

    Citation: Molecular Neurodegeneration 2021 16:40

    Content type: Research article

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  34. For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenera...

    Authors: Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Efrat Sharon, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Tomer-Meir Salame and Michal Schwartz

    Citation: Molecular Neurodegeneration 2021 16:39

    Content type: Research article

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  35. Parkinson’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathol...

    Authors: Alessandro Gialluisi, Mafalda Giovanna Reccia, Nicola Modugno, Teresa Nutile, Alessia Lombardi, Luca Giovanni Di Giovannantonio, Sara Pietracupa, Daniela Ruggiero, Simona Scala, Stefano Gambardella, Licia Iacoviello, Fernando Gianfrancesco, Dario Acampora, Maurizio D’Esposito, Antonio Simeone, Marina Ciullo…

    Citation: Molecular Neurodegeneration 2021 16:35

    Content type: Research article

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  36. Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer’s disease (AD) and are associated with accelerated cognitive impairment and earlier deaths. This review aims to explore the neural pathoge...

    Authors: Yaojing Chen, Mingxi Dang and Zhanjun Zhang

    Citation: Molecular Neurodegeneration 2021 16:38

    Content type: Review

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  37. Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer’s disease (AD) patient brains. In tauopathies like AD, increased phosphorylation or...

    Authors: Yuxing Xia, Stefan Prokop and Benoit I. Giasson

    Citation: Molecular Neurodegeneration 2021 16:37

    Content type: Review

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  38. Early challenges to axonal physiology, active transport, and ultrastructure are endemic to age-related neurodegenerative disorders, including those affecting the optic nerve. Chief among these, glaucoma causes...

    Authors: Michael L. Risner, Silvia Pasini, Nolan R. McGrady, Karis B. D’Alessandro, Vincent Yao, Melissa L. Cooper and David J. Calkins

    Citation: Molecular Neurodegeneration 2021 16:36

    Content type: Research article

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  39. There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of do...

    Authors: Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon…

    Citation: Molecular Neurodegeneration 2021 16:34

    Content type: Research article

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  40. Mutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue.

    Authors: Souvarish Sarkar, Farah Bardai, Abby L. Olsen, Kelly M. Lohr, Ying-Yi Zhang and Mel B. Feany

    Citation: Molecular Neurodegeneration 2021 16:33

    Content type: Research article

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  41. Passive immunotherapies targeting Aβ continue to be evaluated as Alzheimer’s disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of p...

    Authors: Yona Levites, Cory Funk, Xue Wang, Paramita Chakrabarty, Karen N. McFarland, Baxter Bramblett, Veronica O’Neal, Xufei Liu, Thomas Ladd, Max Robinson, Mariet Allen, Minerva M. Carrasquillo, Dennis Dickson, Pedro Cruz, Danny Ryu, Hong-Dong Li…

    Citation: Molecular Neurodegeneration 2021 16:32

    Content type: Research article

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  42. Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dys...

    Authors: Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bjørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle and Charalampos Tzoulis

    Citation: Molecular Neurodegeneration 2021 16:31

    Content type: Research article

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