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156 result(s) for 'mayo clinic' within Molecular Neurodegeneration

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  1. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaoqiang Tang, Arturo Toro, T. G. Sahana, Junli Gao, Jessica Chalk, Björn Oskarsson and Ke Zhang
    Citation: Molecular Neurodegeneration 2020 15:37

    The original article was published in Molecular Neurodegeneration 2020 15:34

  2. Ever since a GGGGCC hexanucleotide repeat expansion mutation in C9ORF72 was identified as the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), three competing b...

    Authors: Xiaoqiang Tang, Arturo Toro, Sahana T.G., Junli Gao, Jessica Chalk, Björn E. Oskarsson and Ke Zhang
    Citation: Molecular Neurodegeneration 2020 15:34

    The Correction to this article has been published in Molecular Neurodegeneration 2020 15:37

  3. Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the ...

    Authors: Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Mackenzie, Michel Roberge…
    Citation: Molecular Neurodegeneration 2020 15:21
  4. The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. Th...

    Authors: Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Anatha, Tania F. Gendron, Claes Wahlestedt, Yanbin Zhang, Michael Benatar, Christian Mueller…
    Citation: Molecular Neurodegeneration 2020 15:13
  5. All samples were obtained through the ALS Center at Mayo Clinic Florida. Our primary cohort included 75 unrelated...C9orf72 repeat, 33 patients who did not possess this expansion, and 20 control subjects without ...

    Authors: Jazmyne L. Jackson, NiCole A. Finch, Matthew C. Baker, Jennifer M. Kachergus, Mariely DeJesus-Hernandez, Kimberly Pereira, Elizabeth Christopher, Mercedes Prudencio, Michael G. Heckman, E. Aubrey Thompson, Dennis W. Dickson, Jaimin Shah, Björn Oskarsson, Leonard Petrucelli, Rosa Rademakers and Marka van Blitterswijk
    Citation: Molecular Neurodegeneration 2020 15:7
  6. Misfolding and aggregation of the presynaptic protein alpha-synuclein (αsyn) is a hallmark of Parkinson’s disease (PD) and related synucleinopathies. Although predominantly localized in the cytosol, a body of ...

    Authors: Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos and Pamela J. McLean
    Citation: Molecular Neurodegeneration 2020 15:5
  7. New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in ...

    Authors: Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell and Gregory W. Carter
    Citation: Molecular Neurodegeneration 2019 14:50
  8. Alzheimer’s disease is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline, although less common clinical presentations are increasingly recognized. The car...

    Authors: Michael A. DeTure and Dennis W. Dickson
    Citation: Molecular Neurodegeneration 2019 14:32
  9. Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant...

    Authors: Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari and Carlos Cruchaga
    Citation: Molecular Neurodegeneration 2019 14:18
  10. A G4C2 hexanucleotide repeat expansion in the noncoding region of C9orf72 is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). Putative disease mechanisms underlyin...

    Authors: Jeannie Chew, Casey Cook, Tania F. Gendron, Karen Jansen-West, Giulia del Rosso, Lillian M. Daughrity, Monica Castanedes-Casey, Aishe Kurti, Jeannette N. Stankowski, Matthew D. Disney, Jeffrey D. Rothstein, Dennis W. Dickson, John D. Fryer, Yong-Jie Zhang and Leonard Petrucelli
    Citation: Molecular Neurodegeneration 2019 14:9
  11. Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer’s disease (AD). However, the gene expression changes underlying microglia act...

    Authors: Hong Wang, Yupeng Li, John W. Ryder, Justin T. Hole, Philip J. Ebert, David C. Airey, Hui-Rong Qian, Benjamin Logsdon, Alice Fisher, Zeshan Ahmed, Tracey K. Murray, Annalisa Cavallini, Suchira Bose, Brian J. Eastwood, David A. Collier, Jeffrey L. Dage…
    Citation: Molecular Neurodegeneration 2018 13:65
  12. Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD).

    Authors: Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen…
    Citation: Molecular Neurodegeneration 2018 13:53
  13. Many neurodegenerative diseases are caused by nucleotide repeat expansions, but most expansions, like the C9orf72 ‘GGGGCC’ (G4C2) repeat that causes approximately 5–7% of all amyotrophic lateral sclerosis (ALS) a...

    Authors: Mark T. W. Ebbert, Stefan L. Farrugia, Jonathon P. Sens, Karen Jansen-West, Tania F. Gendron, Mercedes Prudencio, Ian J. McLaughlin, Brett Bowman, Matthew Seetin, Mariely DeJesus-Hernandez, Jazmyne Jackson, Patricia H. Brown, Dennis W. Dickson, Marka van Blitterswijk, Rosa Rademakers, Leonard Petrucelli…
    Citation: Molecular Neurodegeneration 2018 13:46
  14. Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal ganglia, diencephalon and brainstem. While PSP is larg...

    Authors: Monica Y. Sanchez-Contreras, Naomi Kouri, Casey N. Cook, Daniel J. Serie, Michael G. Heckman, NiCole A. Finch, Richard J. Caselli, Ryan J. Uitti, Zbigniew K. Wszolek, Neill Graff-Radford, Leonard Petrucelli, Li-San Wang, Gerard D. Schellenberg, Dennis W. Dickson, Rosa Rademakers and Owen A. Ross
    Citation: Molecular Neurodegeneration 2018 13:37
  15. Single nucleotide polymorphisms (SNPs) inherited as one of two common haplotypes at the transmembrane protein 106B (TMEM106B) locus are associated with the risk of multiple neurodegenerative diseases, including f...

    Authors: Yingxue Ren, Marka van Blitterswijk, Mariet Allen, Minerva M. Carrasquillo, Joseph S. Reddy, Xue Wang, Thomas G. Beach, Dennis W. Dickson, Nilüfer Ertekin-Taner, Yan W. Asmann and Rosa Rademakers
    Citation: Molecular Neurodegeneration 2018 13:35
  16. Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function...

    Authors: Andrew E. Arrant, Alexandra M. Nicholson, Xiaolai Zhou, Rosa Rademakers and Erik D. Roberson
    Citation: Molecular Neurodegeneration 2018 13:32
  17. Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ...

    Authors: Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman and John R. Cirrito
    Citation: Molecular Neurodegeneration 2018 13:22
  18. TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. Whi...

    Authors: Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu and Xiao-Fen Chen
    Citation: Molecular Neurodegeneration 2018 13:15
  19. Early onset Parkinson’s disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but the function of DJ-1 and how it relates to PINK1 a...

    Authors: David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo…
    Citation: Molecular Neurodegeneration 2017 12:70
  20. Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has...

    Authors: Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson and Leonard Petrucelli
    Citation: Molecular Neurodegeneration 2017 12:55
  21. Amyotrophic Lateral Sclerosis (ALS) is a fatal and progressive neurodegenerative disorder with identified genetic causes representing a significant minority of all cases. A GGGGCC hexanucleotide repeat expansi...

    Authors: Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller and Zane Zeier
    Citation: Molecular Neurodegeneration 2017 12:46
  22. Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whe...

    Authors: Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson III, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty
    Citation: Molecular Neurodegeneration 2017 12:40
  23. Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused...

    Authors: Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M. Ravits, Anatoly Starkov and Giovanni Manfredi
    Citation: Molecular Neurodegeneration 2017 12:37
  24. Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a...

    Authors: Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek and Wolfdieter Springer
    Citation: Molecular Neurodegeneration 2017 12:32
  25. Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to ...

    Authors: Katarzyna Marta Zoltowska, Masato Maesako, Iryna Lushnikova, Shuko Takeda, Laura J. Keller, Galina Skibo, Bradley T. Hyman and Oksana Berezovska
    Citation: Molecular Neurodegeneration 2017 12:15
  26. APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences respo...

    Authors: Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M. Sullivan, David M. Holtzman and Martin J. Sadowski
    Citation: Molecular Neurodegeneration 2017 12:12
  27. Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn ...

    Authors: Emily J. Koller, Mieu M. T. Brooks, Todd E. Golde, Benoit I. Giasson and Paramita Chakrabarty
    Citation: Molecular Neurodegeneration 2017 12:1
  28. Genetic analyses showed that the triggering receptor expressed in myeloid cells 2 (TREM2) p.R47H variant increases the risk for Alzheimer’s disease (AD). The question of whether the p.R47H mutation affects exp...

    Authors: Li Ma, Mariet Allen, Nobutaka Sakae, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Dennis W. Dickson, Steven G. Younkin and Daniel Sevlever
    Citation: Molecular Neurodegeneration 2016 11:72
  29. Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy,...

    Authors: Jaekwang Kim, Fabienne C. Fiesel, Krystal C. Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer and Jungsu Kim
    Citation: Molecular Neurodegeneration 2016 11:55
  30. The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark pathology of Alzheimer’s disease (AD). Previous work has shown increasing serotonin levels with selective serotonin re-uptake inhibitor (S...

    Authors: Jonathan R. Fisher, Clare E. Wallace, Danielle L. Tripoli, Yvette I. Sheline and John R. Cirrito
    Citation: Molecular Neurodegeneration 2016 11:45
  31. Authors: Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns…
    Citation: Molecular Neurodegeneration 2016 11:42

    The original article was published in Molecular Neurodegeneration 2016 11:31

  32. The accumulation, aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to the pathogenesis of Alzheimer’s disease (AD). Alzheimer’s disease risk increases significantly in individuals...

    Authors: Yuan Fu, Jing Zhao, Yuka Atagi, Henrietta M. Nielsen, Chia-Chen Liu, Honghua Zheng, Mitsuru Shinohara, Takahisa Kanekiyo and Guojun Bu
    Citation: Molecular Neurodegeneration 2016 11:37
  33. Tauopathy is characterized by neurofibrillary tangles composed of insoluble hyperphosphorylated tau protein. Currently, cellular models that mimic neurofibrillary tangles in vitro are lacking. Previous studies...

    Authors: Yin Xu, Heidi Martini-Stoica and Hui Zheng
    Citation: Molecular Neurodegeneration 2016 11:32
  34. Biological pathways that significantly contribute to sporadic Alzheimer’s disease are largely unknown and cannot be observed directly. Cognitive symptoms appear only decades after the molecular disease onset, ...

    Authors: Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns…
    Citation: Molecular Neurodegeneration 2016 11:31

    The Erratum to this article has been published in Molecular Neurodegeneration 2016 11:42

  35. Substantial evidence suggests that amyloid-β (Aβ) species induce oxidative stress and cerebrovascular (CV) dysfunction in Alzheimer’s disease (AD), potentially contributing to the progressive dementia of this ...

    Authors: Matthew R. Reynolds, Itender Singh, Tej D. Azad, Brandon B. Holmes, Phillip B. Verghese, Hans H. Dietrich, Marc Diamond, Guojun Bu, Byung Hee Han and Gregory J. Zipfel
    Citation: Molecular Neurodegeneration 2016 11:9
  36. Lrrk2, a gene linked to Parkinson’s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the pres...

    Authors: Elisa Belluzzi, Adriano Gonnelli, Maria-Daniela Cirnaru, Antonella Marte, Nicoletta Plotegher, Isabella Russo, Laura Civiero, Susanna Cogo, Maria Perèz Carrion, Cinzia Franchin, Giorgio Arrigoni, Mariano Beltramini, Luigi Bubacco, Franco Onofri, Giovanni Piccoli and Elisa Greggio
    Citation: Molecular Neurodegeneration 2016 11:1
  37. Apolipoprotein E (ApoE) is a major cholesterol carrier and plays an important role in maintaining lipid homeostasis both in the periphery and brain. Human APOE gene is polymorphic at two single nucleotides (rs429...

    Authors: Li Zhong, Yong-Zhuang Xie, Tian-Tian Cao, Zongqi Wang, Tingting Wang, Xinxiu Li, Rui-Chi Shen, Huaxi Xu, Guojun Bu and Xiao-Fen Chen
    Citation: Molecular Neurodegeneration 2016 11:2
  38. Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are both neurodegenerative diseases leading to impaired execution of movement. α-Synuclein plays a central role in the pathogenesis of PD wherea...

    Authors: Anika M. Helferich, Wolfgang P. Ruf, Veselin Grozdanov, Axel Freischmidt, Marisa S. Feiler, Lisa Zondler, Albert C. Ludolph, Pamela J. McLean, Jochen H. Weishaupt and Karin M. Danzer
    Citation: Molecular Neurodegeneration 2015 10:66
  39. In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune proc...

    Authors: Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo LaDu, David W. Fardo, G. William Rebeck and Steven Estus
    Citation: Molecular Neurodegeneration 2015 10:52
  40. Authors: Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G. Crump, Oliver J. Culley, Talisha A. Hunter, Gina D. Bisceglio, Linda Younkin, Mariet Allen, Minerva M. Carrasquillo, Sigrid B. Sando, Jan O. Aasly, Dennis W. Dickson, Neill R. Graff-Radford, Ronald C. Petersen…
    Citation: Molecular Neurodegeneration 2015 10:49

    The original article was published in Molecular Neurodegeneration 2015 10:18

  41. Pallido-ponto-nigral degeneration (PPND), a major subtype of frontotemporal dementia with parkinsonism related to chromosome 17 (FTDP-17), is a progressive and terminal neurodegenerative disease caused by c.83...

    Authors: Melissa C. Wren, Jing Zhao, Chia-Chen Liu, Melissa E. Murray, Yuka Atagi, Mary D. Davis, Yuan Fu, Hirotaka J. Okano, Kotaro Ogaki, Audrey J. Strongosky, Pawel Tacik, Rosa Rademakers, Owen A. Ross, Dennis W. Dickson, Zbigniew K. Wszolek, Takahisa Kanekiyo…
    Citation: Molecular Neurodegeneration 2015 10:46
  42. Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and regeneration. The innate immune ...

    Authors: Meghan M. Painter, Yuka Atagi, Chia-Chen Liu, Rosa Rademakers, Huaxi Xu, John D. Fryer and Guojun Bu
    Citation: Molecular Neurodegeneration 2015 10:43
  43. Amyloid-β (Aβ) 42 has been implicated as the initiating molecule in the pathogenesis of Alzheimer’s disease (AD); thus, therapeutic strategies that target Aβ42 are of great interest. γ-Secretase modulators (GS...

    Authors: Joo In Jung, Ashleigh R. Price, Thomas B. Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A. Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H. Koo, Gideon Shapiro, Kevin M. Felsenstein and Todd E. Golde
    Citation: Molecular Neurodegeneration 2015 10:29
  44. TREM2 encodes for triggering receptor expressed on myeloid cells 2 and has rare, coding variants that associate with risk for late-onset Alzheimer’s disease (LOAD) in Caucasians of European and...

    Authors: Sheng Chih Jin, Minerva M Carrasquillo, Bruno A Benitez, Tara Skorupa, David Carrell, Dwani Patel, Sarah Lincoln, Siddharth Krishnan, Michaela Kachadoorian, Christiane Reitz, Richard Mayeux, Thomas S Wingo, James J Lah, Allan I Levey, Jill Murrell, Hugh Hendrie…
    Citation: Molecular Neurodegeneration 2015 10:19
  45. Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyp...

    Authors: Daniel Sevlever, Fanggeng Zou, Li Ma, Sebastian Carrasquillo, Michael G Crump, Oliver J Culley, Talisha A Hunter, Gina D Bisceglio, Linda Younkin, Mariet Allen, Minerva M Carrasquillo, Sigrid B Sando, Jan O Aasly, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen…
    Citation: Molecular Neurodegeneration 2015 10:18

    The Erratum to this article has been published in Molecular Neurodegeneration 2015 10:49

  46. Microtubule associated protein tau is the major component of the neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer’s disease and several other neurodegenerative diseases. Tau mutati...

    Authors: Lixin Song, Sherry X Lu, Xuesong Ouyang, Jerry Melchor, Julie Lee, Giuseppe Terracina, Xiaohai Wang, Lynn Hyde, J Fred Hess, Eric M Parker and Lili Zhang
    Citation: Molecular Neurodegeneration 2015 10:14
  47. Human apolipoprotein E (apoE) exists in three major isoforms: apoE2, apoE3 and apoE4. In the brain, apoE is produced mostly by astrocytes and transports cholesterol to neurons via apoE receptors. Among the gen...

    Authors: Jin Hu, Chia-Chen Liu, Xiao-Fen Chen, Yun-wu Zhang, Huaxi Xu and Guojun Bu
    Citation: Molecular Neurodegeneration 2015 10:6
  48. Loss of function COQ2 mutations results in primary CoQ10 deficiency. Recently, recessive mutations of the COQ2 gene have been identified in two unrelated Japanese families with multiple system atrophy (MSA). It h...

    Authors: Kotaro Ogaki, Shinsuke Fujioka, Michael G Heckman, Sruti Rayaprolu, Alexandra I Soto-Ortolaza, Catherine Labbé, Ronald L Walton, Oswaldo Lorenzo-Betancor, Xue Wang, Yan Asmann, Rosa Rademakers, Neill Graff-Radford, Ryan Uitti, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson…
    Citation: Molecular Neurodegeneration 2014 9:44
  49. The accumulation of α-synuclein aggregates is the hallmark of Parkinson’s disease, and more generally of synucleinopathies. The accumulation of tau aggregates however is classically found in the brains of pati...

    Authors: Simon Moussaud, Daryl R Jones, Elisabeth L Moussaud-Lamodière, Marion Delenclos, Owen A Ross and Pamela J McLean
    Citation: Molecular Neurodegeneration 2014 9:43