Articles
160 result(s) for 'mayo clinic' within Molecular Neurodegeneration
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Citation: Molecular Neurodegeneration 2009 4:7
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Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
Insulin-degrading enzyme (IDE) is a ubiquitously expressed zinc-metalloprotease that degrades several pathophysiologically significant extracellular substrates, including insulin and the amyloid β-protein (Aβ)...
Citation: Molecular Neurodegeneration 2009 4:4 -
In vivo silencing of alpha-synuclein using naked siRNA
Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA cont...
Citation: Molecular Neurodegeneration 2008 3:19 -
Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived...
Citation: Molecular Neurodegeneration 2008 3:5 -
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels
Alzheimer's disease (AD) is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ) in extracellular plaques. Mutations in amyloid precursor protein (APP) and presenilins al...
Citation: Molecular Neurodegeneration 2007 2:11 -
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells
Signal peptide peptidase (SPP) is an intramembrane cleaving protease identified by its cleavage of several type II membrane signal peptides. Conservation of intramembrane active site residues demonstrates that...
Citation: Molecular Neurodegeneration 2006 1:16 -
Las noticias de Madrid (News from Madrid)
Over 5,000 participants attended the 10th International Conference on Alzheimer's Disease (ICAD) and Related Disorders in Madrid, Spain from July 15–20, 2006. Highlights of the conference included reports on b...
Citation: Molecular Neurodegeneration 2006 1:10 -
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression
The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially availa...
Citation: Molecular Neurodegeneration 2006 1:6 -
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been...
Citation: Molecular Neurodegeneration 2006 1:3 -
Zoom in on neurodegeneration
Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of dise...
Citation: Molecular Neurodegeneration 2006 1:1
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- ISSN: 1750-1326 (electronic)