Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, et al: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006, 314: 130-133.
Article
CAS
PubMed
Google Scholar
Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T: TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006, 351: 602-611.
Article
CAS
PubMed
Google Scholar
Rowland LP, Shneider NA: Amyotrophic lateral sclerosis. N Engl J Med. 2001, 344: 1688-1700.
Article
CAS
PubMed
Google Scholar
Munsat TL: Adult motor neuron disease. Merritt's textbook of neurology. Edited by: Rowland LP. 1989, Lea & Febiger, Philadelphia, 682-687.
Google Scholar
Cardarelli R, Kertesz A, Knebl JA: Frontotemporal dementia: a review for primary care physicians. Am Fam Physician. 2010, 82: 1372-1377.
PubMed
Google Scholar
Geser F, Lee VM, Trojanowski JQ: Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology. 2010, 30: 103-112.
Article
PubMed Central
PubMed
Google Scholar
Fecto F, Siddique T: Making connections: pathology and genetics link amyotrophic lateral sclerosis with frontotemporal lobe dementia. J Mol Neurosci. 2011, 45: 663-675.
Article
PubMed
Google Scholar
Lagier-Tourenne C, Polymenidou M, Cleveland DW: TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet. 2010, 19: R46-64.
Article
PubMed Central
CAS
PubMed
Google Scholar
Deng H-X, Chen W, Hong S-T, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, et al: Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 2011, 477: 211-215.
Article
PubMed Central
CAS
PubMed
Google Scholar
Renton Alan E, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, Schymick Jennifer C, Laaksovirta H, Van Swieten John C, Myllykangas L, et al: A Hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011, 72: 257-268.
Article
PubMed Central
CAS
PubMed
Google Scholar
DeJesus-Hernandez M, DeJesus-Hernandez M, Mackenzie Ian R, Boeve Bradley F, Boxer Adam L, Baker M, Rutherford Nicola J, Nicholson Alexandra M, Finch NiCole A, Flynn H, Adamson J, et al: Expanded GGGGCC Hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-Linked FTD and ALS. Neuron. 2011, 72: 245-256.
Article
PubMed Central
CAS
PubMed
Google Scholar
Da Cruz S, Cleveland DW: Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol. 2011, 21: 904-919.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ayala YM, Zago P, D'Ambrogio A, Xu YF, Petrucelli L, Buratti E, Baralle FE: Structural determinants of the cellular localization and shuttling of TDP-43. J Cell Sci. 2008, 121: 3778-3785.
Article
CAS
PubMed
Google Scholar
Buratti E, Baralle FE: The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation. RNA Biol. 2010, 7: 420-429.
Article
CAS
PubMed
Google Scholar
Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, et al: Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci. 2011, 14: 459-468.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tollervey JR, Curk T, Rogelj B, Briese M, Cereda M, Kayikci M, Konig J, Hortobagyi T, Nishimura AL, Zupunski V, et al: Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci. 2011, 14: 452-458.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kawahara Y, Mieda-Sato A: TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc Natl Acad Sci. 2012, 109: 3347-3352.
Article
PubMed Central
CAS
PubMed
Google Scholar
Freibaum BD, Chitta RK, High AA, Taylor JP: Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. J Proteome Res. 2010, 9: 1104-1120.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW: ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci USA. 2010, 107: 13318-13323.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, et al: Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes. J Biol Chem. 2010, 286: 1204-1215.
Article
PubMed Central
PubMed
Google Scholar
Kim SH, Shanware NP, Bowler MJ, Tibbetts RS: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. J Biol Chem. 2010, 285: 34097-34105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ayala YM, De Conti L, Avendano-Vazquez SE, Dhir A, Romano M, D'Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E, Baralle FE: TDP-43 regulates its mRNA levels through a negative feedback loop. EMBO J. 2011, 30: 277-288.
Article
PubMed Central
CAS
PubMed
Google Scholar
Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, et al: Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J Neurosci. 2010, 30: 10851-10859.
Article
PubMed Central
CAS
PubMed
Google Scholar
Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011, 121: 726-738.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wu L-S, Cheng W-C, Hou S-C, Yan Y-T, Jiang S-T, Shen CKJ: TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis. 2010, 48: 56-62.
CAS
PubMed
Google Scholar
Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P, Herz J, Yu G: TDP-43 is a developmentally-regulated protein essential for early embryonic development. J Biol Chem. 2009, 285: 6826-6834.
Article
PubMed Central
PubMed
Google Scholar
Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD: Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathol. 2010, 119: 409-419.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, et al: TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis. Science. 2008, 319: 1668-1672.
Article
CAS
PubMed
Google Scholar
Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Velde CV, Bouchard J-P, Lacomblez L, Pochigaeva K, Salachas F, et al: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet. 2008, 40: 572-574.
Article
CAS
PubMed
Google Scholar
Feiguin F, Godena VK, Romano G, D'Ambrogio A, Klima R, Baralle FE: Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior. FEBS Lett. 2009, 583: 1586-1592.
Article
CAS
PubMed
Google Scholar
Lu Y, Ferris J, Gao FB: Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching. Mol Brain. 2009, 2: 30-
Article
PubMed Central
PubMed
Google Scholar
Li Y, Ray P, Rao EJ, Shi C, Guo W, Chen X, Woodruff EA, Fushimi K, Wu JY: A Drosophila model for TDP-43 proteinopathy. Proc Natl Acad Sci USA. 2009, 107: 3169-3174.
Article
Google Scholar
Estes PS, Boehringer A, Zwick R, Tang JE, Grigsby B, Zarnescu DC: Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Hum Mol Genet. 2011, 20: 2308-2321.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang JW, Brent JR, Tomlinson A, Shneider NA, McCabe BD: The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. J Clin Invest. 2011, 121: 4118-4126.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kabashi E, Lin L, Tradewell ML, Dion PA, Bercier V, Bourgouin P, Rochefort D, Bel Hadj S, Durham HD, Vande Velde C, et al: Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. Hum Mol Genet. 2010, 19: 671-683.
Article
CAS
PubMed
Google Scholar
Chiang P-M, Ling J, Jeong YH, Price DL, Aja SM, Wong PC: Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci. 2010, 107: 16320-16324.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH: TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci. 2009, 106: 18809-18814.
Article
PubMed Central
CAS
PubMed
Google Scholar
Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, Lewis J, Petrucelli L: Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice. Mol Neurodegener. 2011, 6: 73-
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhou H, Huang C, Chen H, Wang D, Landel CP, Xia PY, Bowser R, Liu YJ, Xia XG: Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS Genet. 2010, 6: e1000887-
Article
PubMed Central
PubMed
Google Scholar
Stallings NR, Puttaparthi K, Luther CM, Burns DK, Elliott JL: Progressive motor weakness in transgenic mice expressing human TDP-43. Neurobiol Dis. 2010, 40: 404-414.
Article
CAS
PubMed
Google Scholar
Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, Smits V, Ceuterick-de Groote C, Van Broeckhoven C, Kumar-Singh S: TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci. 2010, 107: 3858-3863.
Article
PubMed Central
CAS
PubMed
Google Scholar
Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, Julien JP: Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain. 2011, 134: 2610-2626.
Article
PubMed
Google Scholar
Shan X, Chiang P-M, Price DL, Wong PC: Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proc Natl Acad Sci. 2010, 107: 16325-16330.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang T, Hwang HY, Hao H, Talbot C, Wang J: Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Life Span. J Biol Chem. 2012, 287: 8371-8382.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mackenzie IRA, Rademakers R, Neumann M: TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 2010, 9: 995-1007.
Article
CAS
PubMed
Google Scholar
Gregory RI, Yan K-p, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R: The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004, 432: 235-240.
Article
CAS
PubMed
Google Scholar
Brown CL, Maier KC, Stauber T, Ginkel LM, Wordeman L, Vernos I, Schroer TA: Kinesin-2 is a motor for late endosomes and lysosomes. Traffic. 2005, 6: 1114-1124.
Article
CAS
PubMed
Google Scholar
Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD: TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity. J Biol Chem. 2009, 284: 20329-20339.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, et al: Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc Natl Acad Sci USA. 2009, 106: 7607-7612.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yang C, Tan W, Whittle C, Qiu L, Cao L, Akbarian S, Xu Z: The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. PLoS One. 2010, 5: e15878-
Article
PubMed Central
CAS
PubMed
Google Scholar
Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, et al: An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol. 2011, 18: 822-830.
Article
PubMed Central
CAS
PubMed
Google Scholar
Iguchi Y, Katsuno M, Niwa J-i, Yamada S-i, Sone J, Waza M, Adachi H, Tanaka F, Nagata K-i, Arimura N, et al: TDP-43 depletion induces neuronal cell damage through dysregulation of rho family GTPases. J Biol Chem. 2009, 284: 22059-22066.
Article
PubMed Central
CAS
PubMed
Google Scholar
van Eersel J, Ke YD, Gladbach A, Bi M, Gotz J, Kril JJ, Ittner LM: Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons. PLoS One. 2011, 6: e22850-
Article
PubMed Central
CAS
PubMed
Google Scholar
D'Ambrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala YM, Baralle FE: Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo. Nucleic Acids Res. 2009, 37: 4116-4126.
Article
PubMed Central
PubMed
Google Scholar
Nonaka T, Kametani F, Arai T, Akiyama H, Hasegawa M: Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43. Hum Mol Genet. 2009, 18: 3353-3364.
Article
CAS
PubMed
Google Scholar
Lee EB, Lee VMY, Trojanowski JQ: Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nat Rev Neurosci. 2011, 13: 38-50.
PubMed Central
PubMed
Google Scholar
Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, et al: Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. PLoS Genet. 2008, 4: e1000193-
Article
PubMed Central
PubMed
Google Scholar
Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VMY: Expression of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 Proteinopathies. J Biol Chem. 2009, 284: 8516-8524.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kuo PH, Doudeva LG, Wang YT, Shen CK, Yuan HS: Structural insights into TDP-43 in nucleic-acid binding and domain interactions. Nucleic Acids Res. 2009, 37: 1799-1808.
Article
PubMed Central
CAS
PubMed
Google Scholar
Barmada SJ, Skibinski G, Korb E, Rao EJ, Wu JY, Finkbeiner S: Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis. J Neurosci. 2010, 30: 639-649.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liachko NF, Guthrie CR, Kraemer BC: Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy. J Neurosci. 2010, 30: 16208-16219.
Article
PubMed Central
CAS
PubMed
Google Scholar
Johnson BS, McCaffery JM, Lindquist S, Gitler AD: A yeast TDP-43 proteinopathy model: exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci. 2008, 105: 6439-6444.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD: Neurotoxic effects of TDP-43 overexpression in C. elegans. Hum Mol Genet. 2010, 19: 3206-3218.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang T, Mullane PC, Periz G, Wang J: TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling. Hum Mol Genet. 2011, 20: 1952-1965.
Article
PubMed Central
CAS
PubMed
Google Scholar
Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS: TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol. 2007, 66: 152-157.
Article
PubMed
Google Scholar
Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, Fujita K, Kaneko S, Okamoto Y, et al: Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation. Acta Neuropathol. 2011, 122: 223-229.
Article
PubMed
Google Scholar
Deng H-X, Bigio EH, Zhai H, Fecto F, Ajroud K, Shi Y, Yan J, Mishra M, Ajroud-Driss S, Heller S, et al: Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations. Arch Neurol. 2011, 68: 1057-1061.
Article
PubMed Central
PubMed
Google Scholar
Farrer MJ, Hulihan MM, Kachergus JM, Dachsel JC, Stoessl AJ, Grantier LL, Calne S, Calne DB, Lechevalier B, Chapon F, et al: DCTN1 mutations in Perry syndrome. Nat Genet. 2009, 41: 163-165.
Article
PubMed Central
CAS
PubMed
Google Scholar
Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, et al: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 2010, 466: 1069-1075.
Article
PubMed Central
CAS
PubMed
Google Scholar
Balch WE, Morimoto RI, Dillin A, Kelly JW: Adapting proteostasis for disease intervention. Science. 2008, 319: 916-919.
Article
CAS
PubMed
Google Scholar
Ju JS, Fuentealba RA, Miller SE, Jackson E, Piwnica-Worms D, Baloh RH, Weihl CC: Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009, 187: 875-888.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kim SH, Shi Y, Hanson KA, Williams LM, Sakasai R, Bowler MJ, Tibbetts RS: Potentiation of ALS-associated TDP-43 aggregation by the proteasome-targeting factor, Ubiquilin 1. J Biol Chem. 2008, 284: 8083-8092. M808064200
Article
PubMed
Google Scholar
Igaz LM, Kwong LK, Xu Y, Truax AC, Uryu K, Neumann M, Clark CM, Elman LB, Miller BL, Grossman M, et al: Enrichment of C-terminal fragments in TAR DNA-Binding Protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am J Pathol. 2008, 173: 182-194.
Article
PubMed Central
CAS
PubMed
Google Scholar
Seilhean D, Cazeneuve C, Thuries V, Russaouen O, Millecamps S, Salachas F, Meininger V, Leguern E, Duyckaerts C: Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation. Acta Neuropathol. 2009, 118: 561-573.
Article
PubMed
Google Scholar
King A, Sweeney F, Bodi I, Troakes C, Maekawa S, Al-Sarraj S: Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease. Neuropathology. 2010, 30: 408-419.
Article
PubMed
Google Scholar
McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, et al: TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010, 69: 918-929.
Article
PubMed Central
CAS
PubMed
Google Scholar
Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M: Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. J Neuropathol Exp Neurol. 2008, 67: 555-564.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda JE, Arnold SE, Siderowf A, Grossman M, Leverenz JB, et al: Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathol. 2007, 114: 221-229.
Article
CAS
PubMed
Google Scholar
Chiu AS, Gehringer MM, Welch JH, Neilan BA: Does alpha-amino-beta-methylaminopropionic acid (BMAA) play a role in neurodegeneration?. Int J Environ Res Public Health. 2011, 8: 3728-3746.
Article
PubMed Central
CAS
PubMed
Google Scholar
Callaghan B, Feldman D, Gruis K, Feldman E: The association of exposure to lead, mercury, and selenium and the development of amyotrophic lateral sclerosis and the epigenetic implications. Neurodegener Dis. 2011, 8: 1-8.
Article
CAS
PubMed
Google Scholar
Costanza A, Weber K, Gandy S, Bouras C, Hof PR, Giannakopoulos P, Canuto A: Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. Neuropathol Appl Neurobiol. 2011, 37: 570-584.
Article
PubMed Central
CAS
PubMed
Google Scholar
Migliore L, Coppede F: Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat Res. 2009, 667: 82-97.
Article
CAS
PubMed
Google Scholar
Strong MJ, Volkening K, Hammond R, Yang W, Strong W, Leystra-Lantz C, Shoesmith C: TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Mol Cell Neurosci. 2007, 35: 320-327.
Article
CAS
PubMed
Google Scholar
Brandmeir NJ, Geser F, Kwong LK, Zimmerman E, Qian J, Lee VM, Trojanowski JQ: Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease. Acta Neuropathol. 2008, 115: 123-131.
Article
PubMed
Google Scholar
Mori F, Tanji K, Zhang HX, Nishihira Y, Tan CF, Takahashi H, Wakabayashi K: Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol. 2008, 116: 193-203.
Article
CAS
PubMed
Google Scholar
Giordana MT, Piccinini M, Grifoni S, De Marco G, Vercellino M, Magistrello M, Pellerino A, Buccinna B, Lupino E, Rinaudo MT: TDP-43 redistribution is an early event in sporadic amyotrophic lateral sclerosis. Brain Pathol. 2010, 20: 351-360.
Article
CAS
PubMed
Google Scholar
Johnson VE, Stewart W, Trojanowski JQ, Smith DH: Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans. Acta Neuropathol. 2011, 122: 715-726.
Article
PubMed Central
PubMed
Google Scholar
Moisse K, Mepham J, Volkening K, Welch I, Hill T, Strong MJ: Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL−/− mice: support for a role for TDP-43 in the physiological response to neuronal injury. Brain Res. 2009, 1296: 176-186.
Article
CAS
PubMed
Google Scholar
Moisse K, Volkening K, Leystra-Lantz C, Welch I, Hill T, Strong MJ: Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury. Brain Res. 2009, 1249: 202-211.
Article
CAS
PubMed
Google Scholar
Sato T, Takeuchi S, Saito A, Ding W, Bamba H, Matsuura H, Hisa Y, Tooyama I, Urushitani M: Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons. Neuroscience. 2009, 164: 1565-1578.
Article
CAS
PubMed
Google Scholar
Gitcho MA, Strider J, Carter D, Taylor-Reinwald L, Forman MS, Goate AM, Cairns NJ: VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death. J Biol Chem. 2009, 284: 12384-12398.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, Moore J, Tang W, Winton MJ, Neumann M, Trojanowski JQ, et al: TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. J Neurosci. 2010, 30: 7729-7739.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, et al: Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010, 5: e13250-
Article
PubMed Central
PubMed
Google Scholar
Parker SJ, Meyerowitz J, James JL, Liddell JR, Crouch PJ, Kanninen KM, White AR: Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates. Neurochem Int. 2012, 60: 415-424.
Article
CAS
PubMed
Google Scholar
Dewey CM, Cenik B, Sephton CF, Johnson BA, Herz J, Yu G: TDP-43 aggregation in neurodegeneration: are stress granules the key?. Brain Res. 2012, Epub ahead of print at http://www.sciencedirect.com/science/article/pii/S0006899312003095
Google Scholar