Articles
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Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S30
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(-)-Epigallocatechin-3-gallate ameliorates learning and memory impairments by attenuating peroxidation in APP/PS1 transgenic mice
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S29 -
Neuroprotective effect of Curcumin involved in increasing the protein levels of UCP2 and inhibiting oxidative stress induced by chronic cerebral ischemia in vitro
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S26 -
Involvement of 5-lipoxygenase/cysteinyl leukotriene receptor 1 in rotenone- and MPP+-induced BV2 microglial activation
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S24 -
Investigation of genetic variants regulating the expression of metabotropic glutamate receptor, subtype 5 (GRM5) mRNA in human brain
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S23 -
Exploring the role of common regulatory variants in the etiology of late-onset Alzheimer’s disease
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S22 -
Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S20 -
mGluR5 regulated proliferation of neural stem cells after hypoxia with activation of MAPK signaling pathway
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S18 -
Retrovirus mediated hypoxia-responsive element-regulated neurotrophin-3 transduction attenuates brain injury following focal cerebral ischemia in rats
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S16 -
Curcumin protects SH-SY5Y cells from oxidative stress by up-regulating HO-1 via Phosphatidylinositol 3 Kinase/Akt/Nrf-2 and down-regulating HO-2
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S14 -
Molecular pathways to Parkinson’s disease
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):L13 -
Protective effect of uric acid against 6-OHDA-induced injury in SH-SY5Y cells
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S12 -
ApoER2 trafficking, processing and signaling and its participation in neurodegeneration
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):L11 -
Implication of lipid metabolism disturbance and Alzheimer’s disease: focus on the lipoprotein lipase plays an important role in learning and memory function
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):O9 -
Application of bimolecular fluorescence complementation in studying the topology of polytopic proteins
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):O8 -
Presenilins in Alzheimer’s disease and frontotemporal dementia
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):L8 -
The protective effects of TanIIA on neurotoxicity induced by β-amyloid protein through the Cdk5/P35 pathway in cultured primary neurons
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S8 -
Upregulation of astrocytic α7 nicotinic receptors in Alzheimer's disease brain- possible relevant to amyloid pathology
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):O7 -
Sorting out the cell biology of Alzheimer’s disease: focus on BACE1 and APP
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):L6 -
The role of ATP-sensitive potassium channels on DMT1-mediated ferrous iron uptake in SK-N-SH cells
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S6 -
Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S5 -
Gamma-secretase: from pathogenesis to therapeutics
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):L4 -
Stringently regulated p23 expression is critical for coordinated movement in mice: implications for Alzheimer’s disease
Citation: Molecular Neurodegeneration 2012 7(Suppl 1):L2 -
Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
NURR1 (also named as NR4A2) is a member of the steroid/thyroid hormone receptor family, which can bind to DNA and modulate expression of target genes. Previous studies have shown that NURR1 is essential for th...
Citation: Molecular Neurodegeneration 2012 7:4 -
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regul...
Citation: Molecular Neurodegeneration 2012 7:3 -
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously re...
Citation: Molecular Neurodegeneration 2012 7:2 -
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic abs...
Citation: Molecular Neurodegeneration 2012 7:1 -
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD). Clinical development of BACE1...
Citation: Molecular Neurodegeneration 2011 6:88 -
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
p23 belongs to the highly conserved p24 family of type I transmembrane proteins, which participate in the bidirectional protein transport between the endoplasmic reticulum and Golgi apparatus. Mammalian p23 ha...
Citation: Molecular Neurodegeneration 2011 6:87 -
Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is characterized by deposition of fibrillar amyloid β (Aβ) within cerebral vessels. It is commonly seen in the elderly and almost universally present in patients with Alzheime...
Citation: Molecular Neurodegeneration 2011 6:86 -
Adult hippocampal neurogenesis and its role in Alzheimer's disease
The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that altered neurogenesis in the ...
Citation: Molecular Neurodegeneration 2011 6:85 -
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
The p38α MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS d...
Citation: Molecular Neurodegeneration 2011 6:84 -
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic ...
Citation: Molecular Neurodegeneration 2011 6:83 -
Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
Detergent-insoluble protein accumulation and aggregation in the brain is one of the pathological hallmarks of neurodegenerative diseases. Here, we describe the identification of septin 11 (SEPT11), an enriched...
Citation: Molecular Neurodegeneration 2011 6:82 -
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons ...
Citation: Molecular Neurodegeneration 2011 6:81 -
Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes
Atypical expression of cell cycle regulatory proteins has been implicated in Alzheimer's disease (AD), but the molecular mechanisms by which they induce neurodegeneration are not well understood. We examined t...
Citation: Molecular Neurodegeneration 2011 6:80 -
Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
Since the mid-1990's a trickle of publications from scattered independent laboratories have presented data suggesting that the systemic amyloid precursor transthyretin (TTR) could interact with the amyloidogen...
Citation: Molecular Neurodegeneration 2011 6:79 -
Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglial communication, a co-receptor for HIV...
Citation: Molecular Neurodegeneration 2011 6:78 -
Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
Mutations in superoxide dismutase 1 (SOD1), which are one cause of familial amyotrophic lateral sclerosis (fALS), induce misfolding and aggregation of the protein. Misfolding can be detected by the binding of ...
Citation: Molecular Neurodegeneration 2011 6:77 -
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
Aggregatable amyloid β-peptide (Aβ) and non-aggregatable p3-Alcα are metabolic products of the γ-secretase cleavage of amyloid β-protein precursor (APP) and Alcadeinα (Alcα), respectively. Familial AD (FAD) -l...
Citation: Molecular Neurodegeneration 2011 6:76 -
Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis
Mitochondria have roles or appear to have roles in the pathogenesis of several chronic age-related and acute neurological disorders, including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis, Parkin...
Citation: Molecular Neurodegeneration 2011 6:75 -
Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity
The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoi...
Citation: Molecular Neurodegeneration 2011 6:74 -
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degener...
Citation: Molecular Neurodegeneration 2011 6:73 -
Dopamine and α-synuclein dysfunction in Smad3 null mice
Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra (SN). Transforming growth factor-β1 (TGF-β1) levels increase in patients with PD, although the effects of thi...
Citation: Molecular Neurodegeneration 2011 6:72 -
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
Brain-Derived Neurotrophic Factor (BDNF) is the main candidate for neuroprotective therapy for Huntington's disease (HD), but its conditional administration is one of its most challenging problems.
Citation: Molecular Neurodegeneration 2011 6:71 -
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
APP expression misregulation can cause genetic Alzheimer's disease (AD). Recent evidences support the hypothesis that polymorphisms located in microRNA (miRNA) target sites could influence the risk of developi...
Citation: Molecular Neurodegeneration 2011 6:70 -
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebrospinal fluid (CSF) with Alzheimer's disease (AD). Moreo...
Citation: Molecular Neurodegeneration 2011 6:69 -
Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo
Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-...
Citation: Molecular Neurodegeneration 2011 6:68 -
Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain. Abnormal activation of CDK5 is associated with neu...
Citation: Molecular Neurodegeneration 2011 6:67 -
Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease
Parkinson's disease (PD) is a complex disorder caused by genetic, environmental and age-related factors, and it is more prevalent in men. We aimed to identify differentially expressed genes in peripheral blood...
Citation: Molecular Neurodegeneration 2011 6:66
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- ISSN: 1750-1326 (electronic)