Skip to main content

Articles

Page 13 of 20

  1. Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identifie...

    Authors: Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang and Malcolm A Leissring

    Citation: Molecular Neurodegeneration 2012 7:46

    Content type: Research article

    Published on:

  2. Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson’s disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuro...

    Authors: Terina N Martinez, Xi Chen, Sibali Bandyopadhyay, Alfred H Merrill and Malú G Tansey

    Citation: Molecular Neurodegeneration 2012 7:45

    Content type: Research article

    Published on:

  3. Amyotrophic lateral sclerosis (ALS) is a fatal disorder involving the degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are unknown and there are no effective treatments. Defec...

    Authors: Stacey A Sakowski, J Simon Lunn, Angela S Busta, Sang Su Oh, Grettel Zamora-Berridi, Madeline Palmer, Andrew A Rosenberg, Stephen G Philip, James J Dowling and Eva L Feldman

    Citation: Molecular Neurodegeneration 2012 7:44

    Content type: Research article

    Published on:

  4. Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract. Activation of the cha...

    Authors: Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba and Nobuyuki Nukina

    Citation: Molecular Neurodegeneration 2012 7:43

    Content type: Research article

    Published on:

  5. Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with recent evidence implicating oligomeri...

    Authors: Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg and Pamela J McLean

    Citation: Molecular Neurodegeneration 2012 7:42

    Content type: Research article

    Published on:

  6. The multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD). Further investigation to define the role of clusterin in AD phenotypes would be aided by the development...

    Authors: Junjun Chen, Meiyao Wang and Illarion V Turko

    Citation: Molecular Neurodegeneration 2012 7:41

    Content type: Methodology

    Published on:

  7. Mutations or deletions in DJ-1/PARK7 gene are causative for recessive forms of early onset Parkinson’s disease (PD). Wild-type DJ-1 has cytoprotective roles against cell death through multiple pathways. The mo...

    Authors: Haigang Ren, Kai Fu, Chenchen Mu, Xuechu Zhen and Guanghui Wang

    Citation: Molecular Neurodegeneration 2012 7:40

    Content type: Research article

    Published on:

  8. Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Disease modifying therapies targeting Aβ that are in development have been proposed to be more effective if treatment was initiated ...

    Authors: Pritam Das, Christophe Verbeeck, Lisa Minter, Paramita Chakrabarty, Kevin Felsenstein, Thomas Kukar, Ghulam Maharvi, Abdul Fauq, Barbara A Osborne and Todd E Golde

    Citation: Molecular Neurodegeneration 2012 7:39

    Content type: Research article

    Published on:

  9. The intracellular deposition of misfolded proteins is a common neuropathological hallmark of most neurodegenerative disorders. Increasing evidence suggests that these pathogenic proteins may spread to neighbor...

    Authors: Masatoshi Konno, Takafumi Hasegawa, Toru Baba, Emiko Miura, Naoto Sugeno, Akio Kikuchi, Fabienne C Fiesel, Tsutomu Sasaki, Masashi Aoki, Yasuto Itoyama and Atsushi Takeda

    Citation: Molecular Neurodegeneration 2012 7:38

    Content type: Research article

    Published on:

  10. It is well established that vaccination of humans and transgenic animals against fibrillar Aβ prevents amyloid accumulation in plaques and preserves cognitive function in transgenic mouse models. However, auto...

    Authors: Suhail Rasool, Ricardo Albay III, Hilda Martinez-Coria, Leonid Breydo, Jessica Wu, Saskia Milton, Sunit Misra, Andy Tran, Anna Pensalfini, Frank Laferla, Rakez Kayed and Charles G Glabe

    Citation: Molecular Neurodegeneration 2012 7:37

    Content type: Research article

    Published on:

  11. Pro-inflammatory stimuli, including cytokines like Interleukin-1β, Interleukin-6 and Interferon-γ, in the brain have been proposed to exacerbate existing Alzheimer’s disease (AD) neuropathology by increasing a...

    Authors: Paramita Chakrabarty, Li Tianbai, Amanda Herring, Carolina Ceballos-Diaz, Pritam Das and Todd E Golde

    Citation: Molecular Neurodegeneration 2012 7:36

    Content type: Research article

    Published on:

  12. Fibrillar amyloid-like deposits and co-deposits of tau and α-synuclein are found in several common neurodegenerative diseases. Recent evidence indicates that small oligomers are the most relevant toxic aggrega...

    Authors: Georg Nübling, Benedikt Bader, Johannes Levin, Jenna Hildebrandt, Hans Kretzschmar and Armin Giese

    Citation: Molecular Neurodegeneration 2012 7:35

    Content type: Research article

    Published on:

  13. Among the essential biological roles of bone marrow-derived cells, secretion of many soluble factors is included and these small molecules can act upon specific receptors present in many tissues including the ...

    Authors: Victor Tulio Ribeiro-Resende, Alvaro Carrier-Ruiz, Robertha M R Lemes, Ricardo A M Reis and Rosalia Mendez-Otero

    Citation: Molecular Neurodegeneration 2012 7:34

    Content type: Research article

    Published on:

  14. Progranulin (PGRN), a widely secreted growth factor, is involved in multiple biological functions, and mutations located within the PGRN gene (GRN) are a major cause of frontotemporal lobar degeneration with TDP-...

    Authors: Jennifer Gass, Wing C Lee, Casey Cook, Nicole Finch, Caroline Stetler, Karen Jansen-West, Jada Lewis, Christopher D Link, Rosa Rademakers, Anders Nykjær and Leonard Petrucelli

    Citation: Molecular Neurodegeneration 2012 7:33

    Content type: Research article

    Published on:

  15. Alzheimer’s disease (AD) is the most frequently diagnosed neurodegenerative disorder affecting humans, with advanced age being the most prominent risk factor for developing AD. Despite intense research efforts...

    Authors: Carole J Proctor, Ilse Sanet Pienaar, Joanna L Elson and Thomas BL Kirkwood

    Citation: Molecular Neurodegeneration 2012 7:32

    Content type: Research article

    Published on:

  16. The Aβ peptide that accumulates in Alzheimer’s disease (AD) is derived from amyloid precursor protein (APP) following proteolysis by β- and γ-secretases. Substantial evidence indicates that alterations in APP ...

    Authors: Julie Brodeur, Caroline Thériault, Mélissa Lessard-Beaudoin, Alexandre Marcil, Sophie Dahan and Christine Lavoie

    Citation: Molecular Neurodegeneration 2012 7:31

    Content type: Research article

    Published on:

  17. β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular tr...

    Authors: Yonghao Zhao, Yunshu Wang, Jiaye Yang, Xin Wang, Yingjun Zhao, Xian Zhang and Yun-wu Zhang

    Citation: Molecular Neurodegeneration 2012 7:30

    Content type: Research article

    Published on:

  18. Transgenic mice expressing disease-associated proteins have become standard tools for studying human neurological disorders. Transgenes are often expressed using promoters chosen to drive continuous high-level...

    Authors: Shaefali P Rodgers, Heather A Born, Pritam Das and Joanna L Jankowsky

    Citation: Molecular Neurodegeneration 2012 7:28

    Content type: Research article

    Published on:

  19. In 2006, TAR-DNA binding protein 43 kDa (TDP-43) was discovered to be in the intracellular aggregates in the degenerating cells in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTL...

    Authors: Zuo-Shang Xu

    Citation: Molecular Neurodegeneration 2012 7:27

    Content type: Review

    Published on:

  20. The search for biomarkers in Parkinson’s disease (PD) is crucial to identify the disease early and monitor the effectiveness of neuroprotective therapies. We aim to assess whether a gene signature could be det...

    Authors: Leonid Molochnikov, Jose M Rabey, Evgenya Dobronevsky, Ubaldo Bonuccelli, Roberto Ceravolo, Daniela Frosini, Edna Grünblatt, Peter Riederer, Christian Jacob, Judith Aharon-Peretz, Yulia Bashenko, Moussa BH Youdim and Silvia A Mandel

    Citation: Molecular Neurodegeneration 2012 7:26

    Content type: Research article

    Published on:

  21. Mutations in the LRRK2 gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and

    Authors: Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany Dugger, Beate Winner, Iryna Prots, Caroline B Kent, Kenya Nishioka, Wen-Lang Lin, Dennis W Dickson, Christopher J Janus, Matthew J Farrer…

    Citation: Molecular Neurodegeneration 2012 7:25

    Content type: Research article

    Published on:

  22. Fragile X syndrome (FXS) is caused by the absence of the mRNA-binding protein Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene. Overactive signaling by group 1 metabotropic glutamate receptor...

    Authors: Zhao-Hui Xu, Qi Yang, Bin Feng, Shui-bing Liu, Nan Zhang, Jiang-hao Xing, Xiao-Qiang Li, Yu-mei Wu, Guo-Dong Gao and Ming-Gao Zhao

    Citation: Molecular Neurodegeneration 2012 7:24

    Content type: Research article

    Published on:

  23. Early cognitive impairment in Alzheimer Disease (AD) is thought to result from the dysfunctional effect of amyloid beta (Aβ) oligomers targeting the synapses. Some individuals, however, escape cognitive declin...

    Authors: Nicole L Bjorklund, Lindsay C Reese, V-M Sadagoparamanujam, Valeria Ghirardi, Randall L Woltjer and Giulio Taglialatela

    Citation: Molecular Neurodegeneration 2012 7:23

    Content type: Research article

    Published on:

  24. Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear. We previously reported that loss of PINK1 ...

    Authors: Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Núñez, Zhiyin Song, David Chan, Carlos Villalobos and Jie Shen

    Citation: Molecular Neurodegeneration 2012 7:22

    Content type: Research article

    Published on:

  25. Cerebral ischemia has been shown to induce activation of matrix metalloproteinases (MMPs), particularly MMP-9, which is associated with impairment of the neurovasculature, resulting in blood–brain barrier brea...

    Authors: Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun and Zezong Gu

    Citation: Molecular Neurodegeneration 2012 7:21

    Content type: Research article

    Published on:

  26. Despite enormous progress in elucidating the biophysics of aggregation, no cause-and-effect relationship between protein aggregation and neurodegenerative disease has been unequivocally established. Here, we d...

    Authors: Keizo Sugaya and Shiro Matsubara

    Citation: Molecular Neurodegeneration 2012 7:20

    Content type: Research article

    Published on:

  27. A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis....

    Authors: Robert Tamayev and Luciano D’Adamio

    Citation: Molecular Neurodegeneration 2012 7:19

    Content type: Research article

    Published on:

  28. Prion disease transmission and pathogenesis are linked to misfolded, typically protease resistant (PrPres) conformers of the normal cellular prion protein (PrPC), with the former posited to be the principal const...

    Authors: Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson and Steven J Collins

    Citation: Molecular Neurodegeneration 2012 7:18

    Content type: Research article

    Published on:

  29. A considerable proportion of all newly generated cells in the hippocampus will die before becoming fully differentiated, both under normal and pathological circumstances. The caspase-independent apoptosis-indu...

    Authors: Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren and Changlian Zhu

    Citation: Molecular Neurodegeneration 2012 7:17

    Content type: Research article

    Published on:

  30. Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β pept...

    Authors: Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami and Toshiharu Suzuki

    Citation: Molecular Neurodegeneration 2012 7:16

    Content type: Research article

    Published on:

  31. Leucine-rich repeat kinase 2 (LRRK2) is the gene responsible for autosomal-dominant Parkinson’s disease (PD), PARK8, but the mechanism by which LRRK2 mutations cause neuronal dysfunction remains unknown. In the p...

    Authors: Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima, Sadahiro Azuma, Etsuro Ohta and Fumiya Obata

    Citation: Molecular Neurodegeneration 2012 7:15

    Content type: Research article

    Published on:

  32. Abnormal proteostasis due to alterations in protein turnover has been postulated to play a central role in several neurodegenerative diseases. Therefore, the development of techniques to quantify protein turno...

    Authors: Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman and David M Holtzman

    Citation: Molecular Neurodegeneration 2012 7:14

    Content type: Methodology

    Published on:

  33. Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may...

    Authors: Mariet Allen, Fanggeng Zou, High Seng Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak…

    Citation: Molecular Neurodegeneration 2012 7:13

    Content type: Research article

    Published on:

  34. No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Cu...

    Authors: Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine and Marie-Françoise Chesselet

    Citation: Molecular Neurodegeneration 2012 7:12

    Content type: Research article

    Published on:

  35. Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. Neurotrophin receptors are active in signaling endosomes, whi...

    Authors: Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo and Francisca C Bronfman

    Citation: Molecular Neurodegeneration 2012 7:11

    Content type: Research article

    Published on:

  36. Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease characterized by the loss of motor function. Several ALS genes have been identified as their mutations can lead to familial ALS, inc...

    Authors: Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu and Jianhang Jia

    Citation: Molecular Neurodegeneration 2012 7:10

    Content type: Research article

    Published on:

  37. Several studies found that FE65, a cytoplasmic adaptor protein, interacts with APP and LRP1, altering the trafficking and processing of APP. We have previously shown that FE65 interacts with the ApoE receptor,...

    Authors: Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guénette, Toshiharu Suzuki, Paul M Mathews, Daniel TS Pak, G William Rebeck, Yoo-hun Suh, Hee-Sae Park and Hyang-Sook Hoe

    Citation: Molecular Neurodegeneration 2012 7:9

    Content type: Research article

    Published on:

  38. The form(s) of amyloid-β peptide (Aβ) associated with the pathology characteristic of Alzheimer's disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an issue of ...

    Authors: Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine Jr, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley and Mary Jo LaDu

    Citation: Molecular Neurodegeneration 2012 7:8

    Content type: Research article

    Published on:

  39. Retinal degenerations, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), are characterized by photoreceptor loss and anomalous remodeling of the surviving retina that corrupts visua...

    Authors: Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell and Robert E Marc

    Citation: Molecular Neurodegeneration 2012 7:7

    Content type: Research article

    Published on:

  40. A mechanical trauma to the spinal cord can be followed by the development of irreversible and progressive neurodegeneration, as opposed to a temporary or partially reversible neurological damage. An increasing...

    Authors: Ping K Yip and Andrea Malaspina

    Citation: Molecular Neurodegeneration 2012 7:6

    Content type: Review

    Published on: