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  1. Authors: Junfeng Zhang, Qindong Shi, Pengbo Yang, Xi Xu, Xinlin Chen, Cunfang Qi, Jianshui Zhang, Haixia Lu, Pengbo Zhang, Bingqiao Zhao, Ping Zheng and Yong Liu

    Citation: Molecular Neurodegeneration 2012 7(Suppl 1):S16

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  2. Authors: Dehua Chui, Ting Zhou, Liang Zhou, Huan Yang, Xinying Liu, Tingting Liu, Jia Yu, Yi Liu, Xue Fei Wu, Hui Zhang and Dongsheng Fan

    Citation: Molecular Neurodegeneration 2012 7(Suppl 1):O9

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

  3. NURR1 (also named as NR4A2) is a member of the steroid/thyroid hormone receptor family, which can bind to DNA and modulate expression of target genes. Previous studies have shown that NURR1 is essential for th...

    Authors: Xin Heng, Gang Jin, Xin Zhang, Dehuang Yang, Mingzhe Zhu, Shijun Fu, Xuping Li and Weidong Le

    Citation: Molecular Neurodegeneration 2012 7:4

    Content type: Research article

    Published on:

  4. We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regul...

    Authors: Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn…

    Citation: Molecular Neurodegeneration 2012 7:3

    Content type: Research article

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  5. Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously re...

    Authors: Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre and Jie Shen

    Citation: Molecular Neurodegeneration 2012 7:2

    Content type: Research article

    Published on:

  6. The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic abs...

    Authors: Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde and Domenico Pratico

    Citation: Molecular Neurodegeneration 2012 7:1

    Content type: Research article

    Published on:

  7. The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD). Clinical development of BACE1...

    Authors: Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza and Robert Vassar

    Citation: Molecular Neurodegeneration 2011 6:88

    Content type: Research article

    Published on:

  8. p23 belongs to the highly conserved p24 family of type I transmembrane proteins, which participate in the bidirectional protein transport between the endoplasmic reticulum and Golgi apparatus. Mammalian p23 ha...

    Authors: Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent and Gopal Thinakaran

    Citation: Molecular Neurodegeneration 2011 6:87

    Content type: Research article

    Published on:

  9. Cerebral amyloid angiopathy (CAA) is characterized by deposition of fibrillar amyloid β (Aβ) within cerebral vessels. It is commonly seen in the elderly and almost universally present in patients with Alzheime...

    Authors: Byung Hee Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach and Gregory J Zipfel

    Citation: Molecular Neurodegeneration 2011 6:86

    Content type: Research article

    Published on:

  10. The p38α MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS d...

    Authors: Bin Xing, Adam D Bachstetter and Linda J Van Eldik

    Citation: Molecular Neurodegeneration 2011 6:84

    Content type: Research article

    Published on:

  11. Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic ...

    Authors: Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet and Robert H Schiestl

    Citation: Molecular Neurodegeneration 2011 6:83

    Content type: Research article

    Published on:

  12. Detergent-insoluble protein accumulation and aggregation in the brain is one of the pathological hallmarks of neurodegenerative diseases. Here, we describe the identification of septin 11 (SEPT11), an enriched...

    Authors: Yair M Gozal, Nicholas T Seyfried, Marla Gearing, Jonathan D Glass, Craig J Heilman, Joanne Wuu, Duc M Duong, Dongmei Cheng, Qiangwei Xia, Howard D Rees, Jason J Fritz, Deborah S Cooper, Junmin Peng, Allan I Levey and James J Lah

    Citation: Molecular Neurodegeneration 2011 6:82

    Content type: Research article

    Published on:

  13. Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons ...

    Authors: Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet and Ilya Bezprozvanny

    Citation: Molecular Neurodegeneration 2011 6:81

    Content type: Research article

    Published on:

  14. Atypical expression of cell cycle regulatory proteins has been implicated in Alzheimer's disease (AD), but the molecular mechanisms by which they induce neurodegeneration are not well understood. We examined t...

    Authors: Monique Judge, Lisa Hornbeck, Huntington Potter and Jaya Padmanabhan

    Citation: Molecular Neurodegeneration 2011 6:80

    Content type: Research article

    Published on:

  15. Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglial communication, a co-receptor for HIV...

    Authors: Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp and Kurt F Hauser

    Citation: Molecular Neurodegeneration 2011 6:78

    Content type: Research article

    Published on:

  16. Aggregatable amyloid β-peptide (Aβ) and non-aggregatable p3-Alcα are metabolic products of the γ-secretase cleavage of amyloid β-protein precursor (APP) and Alcadeinα (Alcα), respectively. Familial AD (FAD) -l...

    Authors: Tomoko Konno, Saori Hata, Yukiko Hamada, Yuko Horikoshi-Sakuraba, Tadashi Nakaya, Yuhki Saito, Tohru Yamamoto, Takayuki Yamamoto, Masahiro Maeda, Takeshi Ikeuchi, Sam Gandy, Hiroyasu Akatsu and Toshiharu Suzuki

    Citation: Molecular Neurodegeneration 2011 6:76

    Content type: Research article

    Published on:

  17. Mitochondria have roles or appear to have roles in the pathogenesis of several chronic age-related and acute neurological disorders, including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis, Parkin...

    Authors: Yi Wang, Yan Pan, Ann Price and Lee J Martin

    Citation: Molecular Neurodegeneration 2011 6:75

    Content type: Research article

    Published on:

  18. The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoi...

    Authors: Xavier Xifró, Marta Anglada-Huguet, Laura Rué, Ana Saavedra, Esther Pérez-Navarro and Jordi Alberch

    Citation: Molecular Neurodegeneration 2011 6:74

    Content type: Research article

    Published on:

  19. Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degener...

    Authors: Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis and Leonard Petrucelli

    Citation: Molecular Neurodegeneration 2011 6:73

    Content type: Research article

    Published on:

  20. Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra (SN). Transforming growth factor-β1 (TGF-β1) levels increase in patients with PD, although the effects of thi...

    Authors: Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang and Amelia Sánchez-Capelo

    Citation: Molecular Neurodegeneration 2011 6:72

    Content type: Research article

    Published on: