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  1. The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis of Alzheimer's disease (AD). Recent studies highlig...

    Authors: Rodrigo A Fuentealba, Maria Ines Barría, Jiyeon Lee, Judy Cam, Claudia Araya, Claudia A Escudero, Nibaldo C Inestrosa, Francisca C Bronfman, Guojun Bu and Maria-Paz Marzolo
    Citation: Molecular Neurodegeneration 2007 2:14
    Content type: Research article Published on:

  4. Alzheimer's disease (AD) is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ) in extracellular plaques. Mutations in amyloid precursor protein (APP) and presenilins al...

    Authors: Patricia A Lawlor, Ross J Bland, Pritam Das, Robert W Price, Vallie Holloway, Lisa Smithson, Bridget L Dicker, Matthew J During, Deborah Young and Todd E Golde
    Citation: Molecular Neurodegeneration 2007 2:11
    Content type: Research article Published on:

  6. Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of ...

    Authors: Jian-Sheng Gong, Shin-ya Morita, Mariko Kobayashi, Tetsurou Handa, Shinobu C Fujita, Katsuhiko Yanagisawa and Makoto Michikawa
    Citation: Molecular Neurodegeneration 2007 2:9
    Content type: Research article Published on:

  7. A critical issue in understanding Huntington's disease (HD) pathogenesis is how the ubiquitously expressed mutant huntingtin (mhtt) with an expanded polyglutamine repeat can cause selective toxicity of striata...

    Authors: Xiaofeng Gu, Véronique M André, Carlos Cepeda, Shi-Hua Li, Xiao-Jiang Li, Michael S Levine and X William Yang
    Citation: Molecular Neurodegeneration 2007 2:8
    Content type: Research article Published on:

  8. Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-β (Aβ) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated that deletion of the ATP-binding...

    Authors: Suzanne E Wahrle, Aarti R Shah, Anne M Fagan, Scott Smemo, John SK Kauwe, Andrew Grupe, Anthony Hinrichs, Kevin Mayo, Hong Jiang, Leon J Thal, Alison M Goate and David M Holtzman
    Citation: Molecular Neurodegeneration 2007 2:7
    Content type: Research article Published on:

  9. α-synuclein is a small soluble, cytosolic protein which associates with vesicular membranes. It is a component of intracellular Lewy bodies present in Parkinson's disease and a subset of Alzheimer's disease (A...

    Authors: Verena Kallhoff, Erica Peethumnongsin and Hui Zheng
    Citation: Molecular Neurodegeneration 2007 2:6
    Content type: Research article Published on:

  10. The pathological hallmarks of transmissible spongiform encephalopathy (TSE) diseases are the deposition of a misfolded form of a host-encoded protein (PrPres), marked astrocytosis, microglial activation and spong...

    Authors: Michael J Stobart, Debra Parchaliuk, Sharon LR Simon, Jillian LeMaistre, Jozef Lazar, Richard Rubenstein and J David Knox
    Citation: Molecular Neurodegeneration 2007 2:5
    Content type: Research article Published on:

  11. Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretas...

    Authors: Kulandaivelu S Vetrivel, Ping Gong, James W Bowen, Haipeng Cheng, Ying Chen, Meghan Carter, Phuong D Nguyen, Lisa Placanica, Felix T Wieland, Yue-Ming Li, Maria Z Kounnas and Gopal Thinakaran
    Citation: Molecular Neurodegeneration 2007 2:4
    Content type: Research article Published on:

  12. The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Al...

    Authors: Yuzhi Chen, Angela M Bodles, Donna L McPhie, Rachael L Neve, Robert E Mrak and W Sue T Griffin
    Citation: Molecular Neurodegeneration 2007 2:3
    Content type: Research article Published on:

  13. Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly associated with inflam...

    Authors: Gemma Casadesus, Mark A Smith, Samar Basu, Jing Hua, Dae E Capobianco, Sandra L Siedlak, Xiongwei Zhu and George Perry
    Citation: Molecular Neurodegeneration 2007 2:2
    Content type: Research article Published on:

  14. Recent attention has focused on understanding the role of the brain-renin-angiotensin-system (RAS) in stroke and neurodegenerative diseases. Direct evidence of a role for the brain-RAS in Parkinson's disease (...

    Authors: Tom N Grammatopoulos, Susan M Jones, Ferogh A Ahmadi, Brian R Hoover, Lawrence D Snell, Jesse Skoch, Vimal V Jhaveri, Andy M Poczobutt, James A Weyhenmeyer and W Michael Zawada
    Citation: Molecular Neurodegeneration 2007 2:1
    Content type: Research article Published on:

  17. Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To examine whether LRRK2 is direct...

    Authors: Xiongwei Zhu, Asim Babar, Sandra L Siedlak, Qiwei Yang, Genta Ito, Takeshi Iwatsubo, Mark A Smith, George Perry and Shu G Chen
    Citation: Molecular Neurodegeneration 2006 1:17
    Content type: Research article Published on:

  18. Signal peptide peptidase (SPP) is an intramembrane cleaving protease identified by its cleavage of several type II membrane signal peptides. Conservation of intramembrane active site residues demonstrates that...

    Authors: Andrew C Nyborg, Lauren Herl, Oksana Berezovska, Anne V Thomas, Thomas B Ladd, Karen Jansen, Bradley T Hyman and Todd E Golde
    Citation: Molecular Neurodegeneration 2006 1:16
    Content type: Research article Published on:

  19. More than a decade has passed since apolipoprotein E4 (APOE-ε4) was identified as a primary risk factor for Alzheimer 's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein ...

    Authors: G William Rebeck, Mary Jo LaDu, Steven Estus, Guojun Bu and Edwin J Weeber
    Citation: Molecular Neurodegeneration 2006 1:15
    Content type: Review Published on:

  20. Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological data reporting the predispositi...

    Authors: Kate M Webber, Douglas M Stocco, Gemma Casadesus, Richard L Bowen, Craig S Atwood, Laura A Previll, Peggy LR Harris, Xiongwei Zhu, George Perry and Mark A Smith
    Citation: Molecular Neurodegeneration 2006 1:14
    Content type: Research article Published on:

  21. Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result ...

    Authors: Suzanne V Frankfort, Valerie D Doodeman, Remco Bakker, Linda R Tulner, Jos PCM van Campen, Paul HM Smits and Jos H Beijnen
    Citation: Molecular Neurodegeneration 2006 1:13
    Content type: Short report Published on:

  22. Selenium is an essential micronutrient that function through selenoproteins. Selenium deficiency results in lower concentrations of selenium and selenoproteins. The brain maintains it's selenium better than ot...

    Authors: Melinda M Peters, Kristina E Hill, Raymond F Burk and Edwin J Weeber
    Citation: Molecular Neurodegeneration 2006 1:12
    Content type: Research article Published on:

  23. Radon is a ubiquitous noble gas in the environment and a primary source of harmful radiation exposure for humans; it decays in a cascade of daughters (RAD) by releasing the cell damaging high energy alpha part...

    Authors: Berislav Momčilović, Glenn I Lykken and Marvin Cooley
    Citation: Molecular Neurodegeneration 2006 1:11
    Content type: Research article Published on:

  24. Over 5,000 participants attended the 10th International Conference on Alzheimer's Disease (ICAD) and Related Disorders in Madrid, Spain from July 15–20, 2006. Highlights of the conference included reports on b...

    Authors: Suzanne Elizabeth Wahrle
    Citation: Molecular Neurodegeneration 2006 1:10
    Content type: Meeting report Published on:

  25. Cognitive performance declines with increasing age. Possible cellular mechanisms underlying this age-related functional decline remain incompletely understood. Early studies attributed this functional decline ...

    Authors: Mingbo Han, Frank Schottler, Debin Lei, Elizabeth Y Dong, Alexander Bryan and Jianxin Bao
    Citation: Molecular Neurodegeneration 2006 1:9
    Content type: Research article Published on:

  27. Aberrant hyperphosphorylation of tau protein has been implicated in a variety of neurodegenerative disorders. Although a number of protein kinases have been shown to phosphorylate tau in vitro and in vivo, the mo...

    Authors: Xue Zhang, Yun-wu Zhang, Shijie Liu, Ayelen Bulloj, Gary G Tong, Zhuohua Zhang, Francesca-Fang Liao and Huaxi Xu
    Citation: Molecular Neurodegeneration 2006 1:7
    Content type: Research article Published on:

  28. The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially availa...

    Authors: Chad A Dickey, Peter Ash, Natalia Klosak, Wing C Lee, Leonard Petrucelli, Michael Hutton and Christopher B Eckman
    Citation: Molecular Neurodegeneration 2006 1:6
    Content type: Research article Published on:

  29. The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains...

    Authors: Hui Zheng and Edward H Koo
    Citation: Molecular Neurodegeneration 2006 1:5
    Content type: Review Published on:

  30. Mutations in PSEN1 and PSEN2 genes account for the majority of cases of early-onset familial Alzheimer disease. Since the first prediction of a genetic link between PSEN1 and PSEN2 with Alzheimer's disease, many ...

    Authors: Kulandaivelu S Vetrivel, Yun-wu Zhang, Huaxi Xu and Gopal Thinakaran
    Citation: Molecular Neurodegeneration 2006 1:4
    Content type: Review Published on:

  31. The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been...

    Authors: Andrew C Nyborg, Thomas B Ladd, Craig W Zwizinski, James J Lah and Todd E Golde
    Citation: Molecular Neurodegeneration 2006 1:3
    Content type: Research article Published on:

  32. Presenilin-dependent γ-secretase cleavage of several transmembrane proteins, including amyloid-β precursor protein and Notch, mediates the intramembrane proteolysis to liberate their intracellular domains that...

    Authors: Taisuke Tomita, Sayaka Tanaka, Yuichi Morohashi and Takeshi Iwatsubo
    Citation: Molecular Neurodegeneration 2006 1:2
    Content type: Research article Published on:

  33. Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of dise...

    Authors: Guojun Bu, Huaxi Xu and Todd E Golde
    Citation: Molecular Neurodegeneration 2006 1:1
    Content type: Editorial Published on:
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  • ISSN: 1750-1326 (electronic)

Molecular Neurodegeneration

ISSN: 1750-1326